DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and Wsb1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001036026.1	Gene:	Wsb1 / 303336	RGDID:	1307835	Length:	421	Species:	Rattus norvegicus

Alignment Length:	369	Identity:	99/369 - (26%)
Similarity:	149/369 - (40%)	Gaps:	84/369 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GQPGATTSS-------NSSASNKSSLSVKPN----------YTLKFTLAGHTKAVSAVKFSPNGE 85
            |....|.||       ||:...|:    ||.          ::|.|..:...|....|    |.|
  Rat    74 GSKNVTNSSCLKLARQNSNGGQKN----KPREHIIDCGDIVWSLAFGSSVPEKQSRCV----NIE 130

  Fly    86 W-----------LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD-SRLLVSGSDDKTL 138
            |           ||:...:..||||..|.||....:..|...:.|:.::.| |.||||.|.||||
  Rat   131 WHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHIEVVRDLTFAPDGSLLLVSASRDKTL 195

  Fly   139 KVWEL-STGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVS 202
            :||:| ..|..:|.|:||.|:|:.|.|:|..:::.|....::|.:|::.....::.|..|...|.
  Rat   196 RVWDLKDDGNMVKVLRGHQNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRRLEGHHHDVV 260

  Fly   203 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP------------VSFVKFSPNGKY 255
            |..|:.||:|:.::|||....:||...|..|........||            |..|.||.:|.:
  Rat   261 ACDFSPDGALLATASYDTRVYVWDPHIGDTLMEFGHLFPPPTPIFAGGANDRWVRAVSFSHDGLH 325

  Fly   256 ILAATLDNTLKLWD-----------YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNM 309
            :.:...|..::.|.           .|.|.|            |.|:    |.|..:.:|:.|..
  Rat   326 VASLADDKMVRFWSIGDDCPVQVAPLSNGLC------------CAFS----TDGSVLAAGTHDGS 374

  Fly   310 VYIWNLQSKEVVQKLQGHTDTVLCTACHPTENI----IASAALE 349
            ||.|  .:...|..|| |...:......||:.:    :.|..||
  Rat   375 VYFW--ATPRQVSSLQ-HLCRMSIRRVMPTQEVQKLPVPSKMLE 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	90/326 (28%)
		WD40 repeat	75..112	CDD:293791	13/47 (28%)
		WD40 repeat	118..154	CDD:293791	18/37 (49%)
		WD40 repeat	159..195	CDD:293791	7/35 (20%)
		WD40 repeat	202..237	CDD:293791	12/34 (35%)
		WD40 repeat	244..280	CDD:293791	10/46 (22%)
		WD40 repeat	288..325	CDD:293791	10/36 (28%)
		WD40 repeat	331..357	CDD:293791	5/23 (22%)
Wsb1	NP_001036026.1	WD40	38..382	CDD:225201	90/333 (27%)
		WD40	135..388	CDD:238121	75/270 (28%)
		WD40 repeat	174..212	CDD:293791	18/37 (49%)
		WD40 repeat	217..253	CDD:293791	7/35 (20%)
		WD40 repeat	261..299	CDD:293791	12/37 (32%)
		WD40 repeat	314..353	CDD:293791	7/38 (18%)
		SOCS_WSB1_SWIP1	382..421	CDD:239715	9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900