DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and Cfap52

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001094438.2	Gene:	Cfap52 / 303233	RGDID:	1308151	Length:	620	Species:	Rattus norvegicus

Alignment Length:	258	Identity:	62/258 - (24%)
Similarity:	118/258 - (45%)	Gaps:	19/258 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSR 127
            |:.|:...|  ...:.|..:|:.:.|:..|..|:.:....|:...|| |.|::|::.:|.:||.:
  Rat   368 LRITVPNMT--CHGIDFMRDGKSIISAWDDGKIRAFAPESGRLMYTINSAHRIGVTAIATTSDCK 430

  Fly   128 LLVSGSDDKTLKVWEL--STGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD---VRT 187
            .::||..:..::||::  .|.|..:.||.|.:.|.|......:...|:.|.|.:..|||   :|.
  Rat   431 RIISGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRR 495

  Fly   188 GKCL--KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 250
            .:.:  .||      ...|.::.:...|::|..|.....|:...|..::.|....:..|:.:..:
  Rat   496 NQMILANTL------FQCVCYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSLSGSVNGMDIT 554

  Fly   251 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIW 313
            ..|::.:....|:.:|:|||::|:......||...   |.......|.::|||.|.|..:..|
  Rat   555 QEGEHFVTGGHDHLIKVWDYNEGEVTHVGVGHSGN---IMGIRISPGNQYIVSVSADGAILRW 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	62/258 (24%)
		WD40 repeat	75..112	CDD:293791	8/37 (22%)
		WD40 repeat	118..154	CDD:293791	10/37 (27%)
		WD40 repeat	159..195	CDD:293791	10/40 (25%)
		WD40 repeat	202..237	CDD:293791	6/34 (18%)
		WD40 repeat	244..280	CDD:293791	8/35 (23%)
		WD40 repeat	288..325	CDD:293791	8/26 (31%)
		WD40 repeat	331..357	CDD:293791
Cfap52	NP_001094438.2	WD40	9..399	CDD:225201	7/32 (22%)
		WD40	30..399	CDD:295369	7/32 (22%)
		WD40 repeat	67..108	CDD:293791
		WD40 repeat	115..157	CDD:293791
		WD40 repeat	162..199	CDD:293791
		WD40 repeat	205..302	CDD:293791
		WD40 repeat	253..307	CDD:293791
		WD40	277..617	CDD:225201	62/258 (24%)
		WD40	346..615	CDD:295369	62/258 (24%)
		WD40 repeat	380..414	CDD:293791	8/33 (24%)
		WD40 repeat	421..459	CDD:293791	10/37 (27%)
		WD40 repeat	464..492	CDD:293791	8/27 (30%)
		WD40 repeat	500..541	CDD:293791	8/46 (17%)
		WD40 repeat	548..584	CDD:293791	8/35 (23%)
		WD40 repeat	590..616	CDD:293791	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900