DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and POC1B

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_758440.1	Gene:	POC1B / 282809	HGNCID:	30836	Length:	478	Species:	Homo sapiens

Alignment Length:	298	Identity:	91/298 - (30%)
Similarity:	151/298 - (50%)	Gaps:	24/298 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GQPGATTSSNSSASNKSSLSV-----------KPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSS 91
            |...|.||.:.|.:.|...:.           || :...:...||...|::|:|||:|..|||:|
Human    16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKP-HARAYRYVGHKDVVTSVQFSPHGNLLASAS 79

  Fly    92 ADKLIKIW-GAYDGKFEKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGH 155
            .|:.:::| ....|||.: ...|...:..|.:|:|.:.|.:.|:||::|||.:...:.|.:|..|
Human    80 RDRTVRLWIPDKRGKFSE-FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRH 143

  Fly   156 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPV---SAVHFNRDGSLIVSSS 217
            :::|.|..|:|...||||.|.|::::|||....:|:...   ||.|   :.|.||..|:.|.|:.
Human   144 THWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF---SDSVGFANFVDFNPSGTCIASAG 205

  Fly   218 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 282
            .|...::||....:.|:. ....:..|:.:.|.|:|.|::.|:.|.|||:.|..:|:.:.|..||
Human   206 SDQTVKVWDVRVNKLLQH-YQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGH 269

  Fly   283 KNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEV 320
            ....:.:  :|| .||:...||..|..|.:|.....|:
Human   270 TGPVFTV--SFS-KGGELFASGGADTQVLLWRTNFDEL 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	83/261 (32%)
		WD40 repeat	75..112	CDD:293791	15/37 (41%)
		WD40 repeat	118..154	CDD:293791	12/35 (34%)
		WD40 repeat	159..195	CDD:293791	14/35 (40%)
		WD40 repeat	202..237	CDD:293791	10/34 (29%)
		WD40 repeat	244..280	CDD:293791	13/35 (37%)
		WD40 repeat	288..325	CDD:293791	10/33 (30%)
		WD40 repeat	331..357	CDD:293791
POC1B	NP_758440.1	WD40	10..298	CDD:238121	89/290 (31%)
		WD 1	16..55		8/39 (21%)
		WD40 repeat	21..58	CDD:293791	6/37 (16%)
		WD 2	58..99		17/41 (41%)
		WD40 repeat	63..100	CDD:293791	15/37 (41%)
		WD 3	101..139		12/37 (32%)
		WD40 repeat	106..142	CDD:293791	12/35 (34%)
		WD 4	142..181		15/38 (39%)
		WD40 repeat	147..182	CDD:293791	14/34 (41%)
		WD 5	183..223		13/39 (33%)
		WD40 repeat	190..225	CDD:293791	10/35 (29%)
		WD 6	226..265		12/38 (32%)
		WD40 repeat	231..267	CDD:293791	13/35 (37%)
		WD 7	268..307		12/40 (30%)
		WD40 repeat	273..299	CDD:293791	9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910