DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and tup12

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_592910.2	Gene:	tup12 / 2543402	PomBaseID:	SPAC630.14c	Length:	598	Species:	Schizosaccharomyces pombe

Alignment Length:	390	Identity:	120/390 - (30%)
Similarity:	193/390 - (49%)	Gaps:	63/390 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GHP--------GVVHPPQQPL---------PTAPSG--PNSLQPNSVGQPGATTSSNSSASNKS- 54
            |||        ..|.|...||         |..|:.  |.|..||...:....|   |:..||.
pombe   225 GHPPPPSDSANSSVTPIAAPLVVNGKVSGNPPYPAEIIPTSNVPNREEKDWTVT---SNVPNKEP 286

  Fly    55 SLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKF------EKTISGH 113
            .:||:..:||:     ||..:..|:||.:|::|| :..::...::....||.      |.:....
pombe   287 PISVQLLHTLE-----HTSVICYVRFSADGKFLA-TGCNRAAMVFNVETGKLITLLQEESSKREG 345

  Fly   114 KLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 178
            .|.:..||:|.|.:.|.:|.:|:.:::|:::..:..:.|.||...::..:|:.....:||||.|.
pombe   346 DLYVRSVAFSPDGKYLATGVEDQQIRIWDIAQKRVYRLLTGHEQEIYSLDFSKDGKTLVSGSGDR 410

  Fly   179 SVRIWDVRTGKCLKTLPAHSDP-VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 242
            :|.:|||..|:  :.|..|:|. |:.|.|:.||..|.:.|.|.:.||| |:||..::.|...:..
pombe   411 TVCLWDVEAGE--QKLILHTDDGVTTVMFSPDGQFIAAGSLDKVIRIW-TSSGTLVEQLHGHEES 472

  Fly   243 PVSFVKFSPNGKYILAATLDNTLKLWD-----------YSKGK-CLKTYTGHKNEKYCIFANFSV 295
            ..| |.|||:|||:::.:||||:|||:           |.:|. |.:|:||||:     |. .||
pombe   473 VYS-VAFSPDGKYLVSGSLDNTIKLWELQCVSNVAPSMYKEGGICKQTFTGHKD-----FI-LSV 530

  Fly   296 T---GGKWIVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLW 357
            |   .||||:|||:|..:..|:..|......||||.::|:..|..|..:..|:.:  .|...::|
pombe   531 TVSPDGKWIISGSKDRTIQFWSPDSPHSQLTLQGHNNSVISVAVSPNGHCFATGS--GDLRARIW 593

Fly 358 357
pombe 594 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	100/316 (32%)
		WD40 repeat	75..112	CDD:293791	9/42 (21%)
		WD40 repeat	118..154	CDD:293791	9/35 (26%)
		WD40 repeat	159..195	CDD:293791	11/35 (31%)
		WD40 repeat	202..237	CDD:293791	13/34 (38%)
		WD40 repeat	244..280	CDD:293791	19/47 (40%)
		WD40 repeat	288..325	CDD:293791	14/39 (36%)
		WD40 repeat	331..357	CDD:293791	5/25 (20%)
tup12	NP_592910.2	Tup_N	37..115	CDD:285748
		WD40	<284..598	CDD:225201	104/328 (32%)
		WD40	292..594	CDD:238121	101/320 (32%)
		WD40 repeat	302..338	CDD:293791	8/36 (22%)
		WD40 repeat	350..386	CDD:293791	9/35 (26%)
		WD40 repeat	391..426	CDD:293791	12/36 (33%)
		WD40 repeat	433..467	CDD:293791	13/34 (38%)
		WD40 repeat	473..521	CDD:293791	19/48 (40%)
		WD40 repeat	527..563	CDD:293791	13/36 (36%)
		WD40 repeat	569..593	CDD:293791	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770