DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wds and spt8

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_595920.1	Gene:	spt8 / 2539775	PomBaseID:	SPBC14C8.17c	Length:	526	Species:	Schizosaccharomyces pombe

Alignment Length:	403	Identity:	82/403 - (20%)
Similarity:	139/403 - (34%)	Gaps:	144/403 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADK-------------------- 94
            ||..|...|.|  ||...:|   .:::|..|:.:.:||.:...|.
pombe   101 ASTASFYDVVP--TLAIPMA---TSINAFAFTSDLKWLFTGGEDGYIRKYDFFPSINGDLSLTVA 160

  Fly    95 --------------LIKIW-GAYDGKFEKTI---SGHKLGISDVAWSSDSRLLVSGSDDKTLKVW 141
                          |:..| .||||....::   :.|..|:    |      ::||.::..:.::
pombe   161 QRHPFVDTVTKAGILLNYWENAYDGNKPSSVYSLAAHSRGL----W------VLSGVNNGDIILY 215

  Fly   142 EL--STGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAV 204
            ..  ..|..:.:||.|:..|.|...:.....::|||:|:.|..||:.||..:.|....|..:|.:
pombe   216 STRHQEGYPVTSLKKHTAPVSCLALHGSEKKVLSGSWDKMVYYWDLNTGDAISTYNCESGQISNI 280

  Fly   205 HFNRDGSL-----------------IVSSSYDGLCRIWD----------TASGQC---------- 232
            .:...|::                 ..|||||.|   :|          |.|.|.
pombe   281 VYRPSGAVNPWGSESDDMRSLFGTPASSSSYDAL---FDEEVEKAIEEETKSVQANEENETEKPS 342

  Fly   233 -LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY-----------SKG-------KCL-- 276
             .::..::||........|......|..::|..:.:||:           .||       .|.
pombe   343 QTESTTNNDNIKAPSESSSEESNIFLTTSIDGVMNVWDHRMVDSVLKYPVPKGVPPWAMSACWSP 407

  Fly   277 ---KTYTGHKN---EKYCIFAN-------------------FSVTGGKWIVSGSEDNMVYIWNLQ 316
               ..|.|.:|   |:|.|.:.                   :|:..|:.:|..|.|| :.:::||
pombe   408 DGNNIYIGRRNGIVEEYNIHSGKEPVRSLKMPLDSGPVSNVYSMPNGRHLVISSFDN-IRLYDLQ 471

  Fly   317 SKEVVQKL--QGH 327
            ||..:..|  .||
pombe   472 SKAGIGFLIIPGH 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	76/389 (20%)
		WD40 repeat	75..112	CDD:293791	11/74 (15%)
		WD40 repeat	118..154	CDD:293791	5/37 (14%)
		WD40 repeat	159..195	CDD:293791	12/35 (34%)
		WD40 repeat	202..237	CDD:293791	12/72 (17%)
		WD40 repeat	244..280	CDD:293791	8/58 (14%)
		WD40 repeat	288..325	CDD:293791	12/57 (21%)
		WD40 repeat	331..357	CDD:293791
spt8	NP_595920.1	SDA1	<35..>95	CDD:283052
		WD40	120..473	CDD:225201	69/366 (19%)
		WD40	120..469	CDD:295369	67/362 (19%)
		WD40 repeat	121..161	CDD:293791	5/39 (13%)
		WD40 repeat	167..230	CDD:293791	13/72 (18%)
		WD40 repeat	235..271	CDD:293791	12/35 (34%)
		WD40 repeat	299..393	CDD:293791	17/96 (18%)
		WD40 repeat	400..437	CDD:293791	7/36 (19%)
		WD40 repeat	445..482	CDD:293791	11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000