DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and Y53C12B.1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_496100.1	Gene:	Y53C12B.1 / 190203	WormBaseID:	WBGene00013143	Length:	793	Species:	Caenorhabditis elegans

Alignment Length:	226	Identity:	63/226 - (27%)
Similarity:	107/226 - (47%)	Gaps:	15/226 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFE----KTIS 111
            :.|..:...|..|...|:..|.|.|:.|..|.:...:|:...|||:|:|.....|.:    .|:|
Worm   456 AEKDFVEQLPKLTCSSTMVAHGKDVNCVDISESDALIATGGMDKLVKLWQVDTHKMQLGIAGTLS 520

  Fly   112 GHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSF 176
            ||:.|:.||.::.:|..|.|.|.|.|:|:|.:|....|:|:.|||..||...|....:.::|...
Worm   521 GHRRGVGDVKFAKNSHKLASCSGDMTIKIWNISEKSCLQTISGHSCAVFRVIFARNDSQLISADS 585

  Fly   177 DESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 241
            ...::||.::|..|..::.||:|.:.::..|.:.|..|::..||...:|...:.:..|.   :||
Worm   586 AGIIKIWTIKTADCECSIDAHTDKIWSLSKNHNESEFVTAGTDGRIVVWKDVTEEKQKA---EDN 647

  Fly   242 PPVSFVKFSPNGKYILAATLDNTLKLWDYSK 272
            .....::..        .||.|.|....||:
Worm   648 KRREAIEQD--------QTLTNLLSQKRYSE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	60/213 (28%)
		WD40 repeat	75..112	CDD:293791	11/40 (28%)
		WD40 repeat	118..154	CDD:293791	13/35 (37%)
		WD40 repeat	159..195	CDD:293791	8/35 (23%)
		WD40 repeat	202..237	CDD:293791	7/34 (21%)
		WD40 repeat	244..280	CDD:293791	6/29 (21%)
		WD40 repeat	288..325	CDD:293791
		WD40 repeat	331..357	CDD:293791
Y53C12B.1	NP_496100.1	WD40	<22..137	CDD:392136
		WD40 repeat	22..58	CDD:293791
		WD40 repeat	64..107	CDD:293791
		WD40	100..441	CDD:238121
		WD40 repeat	112..149	CDD:293791
		WD40 repeat	153..192	CDD:293791
		WD40 repeat	197..255	CDD:293791
		WD40	312..635	CDD:238121	53/178 (30%)
		WD40 repeat	322..358	CDD:293791
		WD40 repeat	364..410	CDD:293791
		WD40 repeat	415..474	CDD:293791	4/17 (24%)
		WD40 repeat	481..520	CDD:293791	10/38 (26%)
		WD40 repeat	526..562	CDD:293791	13/35 (37%)
		WD40 repeat	568..604	CDD:293791	8/35 (23%)
		WD40 repeat	610..634	CDD:293791	5/23 (22%)
		Utp13	656..789	CDD:370012	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1422
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940