DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and wdr-5.1

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_497749.1	Gene:	wdr-5.1 / 175474	WormBaseID:	WBGene00006474	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	233/361 - (64%)
Similarity:	282/361 - (78%)	Gaps:	17/361 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PPQQ----PLPTAPSG----------PNSLQP-NSVG--QPGATTSSNSSASNKSSLSVKPNYTL 64
            |.||    .:|.||.|          |||:.| |..|  .|||:..:.:..:..:|.|...||.|
Worm    15 PTQQIDQLTVPNAPDGGSSAPAPSTSPNSISPSNPTGTPAPGASAQTPNPNAAGASASGSANYKL 79

  Fly    65 KFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLL 129
            ..||.||||::|:.||||.|::|.:|||||.:|||.......|:|::|||||::|:|||||||.:
Worm    80 MCTLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWSSDSRCV 144

  Fly   130 VSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTL 194
            ||.|||||||::|:.|.:..||||||:||||||||||||:|:||||||||||||||:||.|:|||
Worm   145 VSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMCIKTL 209

  Fly   195 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 259
            ||||||||||.||||||||.|.|||||.||||||:|||:|||:||:||||:|||||||||||||:
Worm   210 PAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVDDENPPVAFVKFSPNGKYILAS 274

  Fly   260 TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKL 324
            .||:||||||:||||.||.||||:|.||||||||||||||||:|||||..:||||||::|:||.|
Worm   275 NLDSTLKLWDFSKGKTLKQYTGHENSKYCIFANFSVTGGKWIISGSEDCKIYIWNLQTREIVQCL 339

  Fly   325 QGHTDTVLCTACHPTENIIASAALENDKTIKLWKSD 360
            :|||..||.:.|||.:|||||.|||.|..|.:|:||
Worm   340 EGHTQPVLASDCHPVQNIIASGALEPDNKIHIWRSD 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	210/293 (72%)
		WD40 repeat	75..112	CDD:293791	17/36 (47%)
		WD40 repeat	118..154	CDD:293791	22/35 (63%)
		WD40 repeat	159..195	CDD:293791	30/35 (86%)
		WD40 repeat	202..237	CDD:293791	28/34 (82%)
		WD40 repeat	244..280	CDD:293791	28/35 (80%)
		WD40 repeat	288..325	CDD:293791	28/36 (78%)
		WD40 repeat	331..357	CDD:293791	15/25 (60%)
wdr-5.1	NP_497749.1	WD40	<76..372	CDD:225201	212/295 (72%)
		WD40	79..373	CDD:238121	210/293 (72%)
		WD40 repeat	90..127	CDD:293791	17/36 (47%)
		WD40 repeat	133..169	CDD:293791	22/35 (63%)
		WD40 repeat	174..210	CDD:293791	30/35 (86%)
		WD40 repeat	217..252	CDD:293791	28/34 (82%)
		WD40 repeat	259..295	CDD:293791	28/35 (80%)
		WD40 repeat	303..340	CDD:293791	28/36 (78%)
		WD40 repeat	346..372	CDD:293791	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157521
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H59931
Inparanoid	1	1.050	483	1.000	Inparanoid score	I801
Isobase	1	0.950	-	0	Normalized mean entropy	S633
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D368256at33208
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	1	1.000	-	-		oto20843
orthoMCL	1	0.900	-	-		OOG6_101464
Panther	1	1.100	-	-	LDO	PTHR22847
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1422
SonicParanoid	1	1.000	-	-		X2149
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.750