DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and W07E6.2

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_493745.1	Gene:	W07E6.2 / 173439	WormBaseID:	WBGene00021074	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	391	Identity:	97/391 - (24%)
Similarity:	158/391 - (40%)	Gaps:	99/391 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFE---KTISGHKLGISD 119
            |:|......::.||.:.|.:.:|||:|..|||.|.|:.::||   |.:.|   .|...||..:..
Worm    91 VRPVTRCSASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIW---DIELELPLHTCKSHKSWVLC 152

  Fly   120 VAWSSDSRLLVSGSDDKTLKVWELSTGKSL-KTLKGHSNYVFCCNF-----NPQSNLIVSGSFDE 178
            :|||.|:..:.|...:..:.:|...||:.: ||||.|..::....:     :|...|:.|...|.
Worm   153 IAWSPDATKIASACKNGEICIWNAKTGEQIGKTLKRHKQWITSLAWQPMHKDPTCRLLASCGKDG 217

  Fly   179 SVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG------------- 230
            ::.|||...|..::.|..|:..|:.:.:..:| ||.|.|.|...::|....|
Worm   218 NIFIWDTVQGTVVRCLSGHTASVTCLRWGGEG-LIYSGSQDRTVKMWRADDGVMCRNMTGHAHWI 281

  Fly   231 --------------------QCLK-------------------------TLI--DDD------NP 242
                                :|:|                         .|:  .||      ||
Worm   282 NTLALNTDYALRTSCFEPSKRCIKPDTVEECQKVAQTRYEAALEIAGGERLVSGSDDFTLFMWNP 346

  Fly   243 P---------------VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 292
            .               |:.|.|||:.:||.:|:.|.::|||....||.|.:..||....|.:..:
Worm   347 KETKQSINRMTGHMQLVNQVVFSPDTRYIASASFDKSVKLWCGRTGKYLASLRGHVGPVYQVAWS 411

  Fly   293 FSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLW 357
               ...:.:||||.|:.:.::.|::|.:...|.||.|.|......|....:.|..  .||.:|||
Worm   412 ---ADSRLLVSGSADSTLKVFELKTKSLYYDLPGHGDEVFTVDWSPEGTKVVSGG--KDKVLKLW 471

  Fly   358 K 358
            :
Worm   472 R 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	94/383 (25%)
		WD40 repeat	75..112	CDD:293791	15/39 (38%)
		WD40 repeat	118..154	CDD:293791	11/36 (31%)
		WD40 repeat	159..195	CDD:293791	8/40 (20%)
		WD40 repeat	202..237	CDD:293791	10/92 (11%)
		WD40 repeat	244..280	CDD:293791	15/35 (43%)
		WD40 repeat	288..325	CDD:293791	7/36 (19%)
		WD40 repeat	331..357	CDD:293791	6/25 (24%)
W07E6.2	NP_493745.1	NLE	7..70	CDD:369718
		WD40	97..430	CDD:238121	81/339 (24%)
		WD40 repeat	110..145	CDD:293791	14/37 (38%)
		WD40 repeat	150..188	CDD:293791	11/37 (30%)
		WD40 repeat	194..235	CDD:293791	9/40 (23%)
		WD40 repeat	240..275	CDD:293791	9/35 (26%)
		WD40 repeat	282..356	CDD:293791	7/73 (10%)
		WD40 repeat	363..399	CDD:293791	15/35 (43%)
		WD40 repeat	405..441	CDD:293791	8/38 (21%)
		WD40	433..471	CDD:197651	11/39 (28%)
		WD40 repeat	447..471	CDD:293791	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910