Protein Alignment wds and CFAP52

DIOPT Version :10

• Sequence 1: NP_524984.1
• Gene: wds / 53428
• FlyBaseID: FBgn0040066
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: XP_047291393.1
• Gene: CFAP52 / 146845
• HGNCID: 16053
• Length: 627
• Species: Homo sapiens
• Alignment Length: 447
• Identity: 82/447 - (18%)
• Similarity: 143/447 - (31%)
• Gaps: 175/447 - (39%)

  Fly    68 LAGHTKAVSAVKFSPNGEWLASS-------SADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 125
            |.||...||.:..|.:||::||.       .||  |.:|...:.:....:|.||..|..:|:|.:
Human    60 LQGHGNNVSCLAISRSGEYIASGQVTFMGFKAD--IILWDYKNRELLARLSLHKGKIEALAFSPN 122

  Fly   126 SRLLVS--GSDDKTLKVWELSTGKSLKTLKGHSNYVFC------CNFNPQSNLIVSGSFDE---- 178
            ...|||  |.||.::.||.::...::           |      .|....:|:|.|...||
Human   123 DLYLVSLGGPDDGSVVVWSIAKRDAI-----------CGSPAAGLNVGNATNVIFSRCRDEMFMT 176

  Fly   179 ----SVRIWDV-------------------------------------RTGKCLKTLP------- 195
                ::|:|::                                     .||..||..|
Human   177 AGNGTIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDSFFYLGTTTGDILKMNPRTKLLTD 241

  Fly   196 ------AHSDPVSAVHFNRDGSLIVSSS------------------------------------- 217
                  ..|..|||:...:.|.|:|.|.
Human   242 VGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFCKSPGYKPIKKIQLQGGITSITLRGEGHQFL 306

  Fly   218 -------------------------YDGL---------------C-----RIWDTASGQCLKTLI 237
                                     :|.:               |     |:|.|:|.:.| ..|
Human   307 VGTEESHIYRVSFTDFKETLIATCHFDAVEDIVFPFGTAELFATCAKKDIRVWHTSSNREL-LRI 370

  Fly   238 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 302
            ...|.....:.|..:||.|::|..|..::.:....|:.:  |..:...:..:.|..:.:..|.::
Human   371 TVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLM--YVINNAHRIGVTAIATTSDCKRVI 433

  Fly   303 SGSEDNMVYIWNL--QSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLW 357
            ||..:..|.:|.:  |::::.:.|:.|..:|.|...........:|:  .|.|..:|
Human   434 SGGGEGEVRVWQIGCQTQKLEEALKEHKSSVSCIRVKRNNEECVTAS--TDGTCIIW 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_524984.1	WD40	<63..361	CDD:441893	82/447 (18%)
		WD40 repeat	75..112	CDD:293791	11/43 (26%)
		WD40 repeat	118..154	CDD:293791	10/37 (27%)
		WD40 repeat	159..195	CDD:293791	13/86 (15%)
		WD40 repeat	202..237	CDD:293791	13/116 (11%)
		WD40 repeat	244..280	CDD:293791	7/35 (20%)
		WD40 repeat	288..325	CDD:293791	7/38 (18%)
		WD40 repeat	331..357	CDD:293791	5/25 (20%)
CFAP52	XP_047291393.1	WD40	46..490	CDD:441893	82/447 (18%)
		WD40 repeat	68..109	CDD:293791	10/42 (24%)
		WD40 repeat	114..159	CDD:293791	13/55 (24%)
		WD40 repeat	166..201	CDD:293791	5/34 (15%)
		WD40 repeat	208..245	CDD:293791	5/36 (14%)
		WD40 repeat	294..330	CDD:293791	0/35 (0%)
		WD40 repeat	335..372	CDD:293791	7/37 (19%)
		WD40 repeat	378..413	CDD:293791	8/36 (22%)
		WD40 repeat	420..458	CDD:293791	7/37 (19%)
		WD40 repeat	464..500	CDD:293791	6/27 (22%)