DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wds and WDR88

DIOPT Version :9

Sequence 1:NP_001245503.1 Gene:wds / 53428 FlyBaseID:FBgn0040066 Length:361 Species:Drosophila melanogaster
Sequence 2:NP_775750.3 Gene:WDR88 / 126248 HGNCID:26999 Length:472 Species:Homo sapiens


Alignment Length:302 Identity:85/302 - (28%)
Similarity:143/302 - (47%) Gaps:21/302 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 LAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDSRLLVS 131
            |:||..|||...|..:...|.|.|.|..:|:|...||...:..... |..:.:.:.:.||..:::
Human    98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIA 162

  Fly   132 GSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLIVSG-SFDESVRIWD---VRTGKCLK 192
            .|.|||::.|:|.|||.|..:: :..::..|.|:|....:||| ..|..:.|.|   :.|...:|
Human   163 ASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIK 226

  Fly   193 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 257
              ..|:..:::..|:.|...:.|.|.|...:|||..|...|.|:....:..:|...|:.:|.::.
Human   227 --DHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLC 289

  Fly   258 AATLDNTLKLWDYSKGK------CLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNMVYIWNL 315
            .::.|..||:|:...|:      |:....||:.. ..|.||..|    .:::||..|..|.||::
Human   290 TSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS----SFLISGGFDRTVAIWDV 350

  Fly   316 QSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLW 357
            ........|:||.|.|:..|....:..|.||:  .|:|::||
Human   351 AEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdsNP_001245503.1 WD40 64..358 CDD:238121 85/302 (28%)
WD40 repeat 75..112 CDD:293791 11/36 (31%)
WD40 repeat 118..154 CDD:293791 12/35 (34%)
WD40 repeat 159..195 CDD:293791 11/39 (28%)
WD40 repeat 202..237 CDD:293791 11/34 (32%)
WD40 repeat 244..280 CDD:293791 9/41 (22%)
WD40 repeat 288..325 CDD:293791 10/36 (28%)
WD40 repeat 331..357 CDD:293791 7/25 (28%)
WDR88NP_775750.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
WD40 96..391 CDD:238121 85/302 (28%)
WD40 97..>398 CDD:225201 85/302 (28%)
WD 1 100..139 14/38 (37%)
WD40 repeat 106..142 CDD:293791 10/35 (29%)
WD 2 143..182 13/38 (34%)
WD40 repeat 148..181 CDD:293791 11/32 (34%)
WD 3 184..224 10/40 (25%)
WD40 repeat 190..226 CDD:293791 10/35 (29%)
WD 4 228..267 11/38 (29%)
WD40 repeat 233..270 CDD:293791 11/36 (31%)
WD 5 271..310 8/38 (21%)
WD40 repeat 276..317 CDD:293791 9/40 (23%)
WD 6 319..358 12/42 (29%)
WD40 repeat 324..348 CDD:293791 8/27 (30%)
WD 7 361..400 12/32 (38%)
WD40 repeat 366..390 CDD:293791 7/25 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 447..472
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0266
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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