Protein Alignment wds and WDR5

DIOPT Version :10

• Sequence 1: NP_524984.1
• Gene: wds / 53428
• FlyBaseID: FBgn0040066
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_060058.1
• Gene: WDR5 / 11091
• HGNCID: 12757
• Length: 334
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 291/319 - (91%)
• Similarity: 304/319 - (95%)
• Gaps: 0/319 - (0%)

  Fly    42 ATTSSNSSASNKSSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKLIKIWGAYDGKF 106
            |..:.:|||:......|||||.|||||||||||||:|||||||||||||||||||||||||||||
Human    15 AQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF 79

  Fly   107 EKTISGHKLGISDVAWSSDSRLLVSGSDDKTLKVWELSTGKSLKTLKGHSNYVFCCNFNPQSNLI 171
            ||||||||||||||||||||.||||.|||||||:|::|:||.|||||||||||||||||||||||
Human    80 EKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144

  Fly   172 VSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 236
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Human   145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209

  Fly   237 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 301
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274

  Fly   302 VSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALENDKTIKLWKSD 360
            |||||||:|||||||:||:|||||||||.|:.|||||||||||||||||||||||||||
Human   275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_524984.1	WD40	<63..361	CDD:441893	282/298 (95%)
		WD40 repeat	75..112	CDD:293791	35/36 (97%)
		WD40 repeat	118..154	CDD:293791	28/35 (80%)
		WD40 repeat	159..195	CDD:293791	34/35 (97%)
		WD40 repeat	202..237	CDD:293791	34/34 (100%)
		WD40 repeat	244..280	CDD:293791	35/35 (100%)
		WD40 repeat	288..325	CDD:293791	33/36 (92%)
		WD40 repeat	331..357	CDD:293791	23/25 (92%)
WDR5	NP_060058.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		4/15 (27%)
		WD40	<36..330	CDD:441893	277/293 (95%)
		WD 1	43..82		37/38 (97%)
		WD40 repeat	48..85	CDD:293791	35/36 (97%)
		WD 2	85..126		33/40 (83%)
		WD40 repeat	91..127	CDD:293791	28/35 (80%)
		WD 3	128..168		38/39 (97%)
		WD40 repeat	132..168	CDD:293791	34/35 (97%)
		WD 4	169..208		38/38 (100%)
		WD40 repeat	175..210	CDD:293791	34/34 (100%)
		WD 5	212..253		40/40 (100%)
		WD40 repeat	217..253	CDD:293791	35/35 (100%)
		WD 6	256..296		36/39 (92%)
		WD40 repeat	261..298	CDD:293791	33/36 (92%)
		WD 7	299..333		30/33 (91%)
		WD40 repeat	304..330	CDD:293791	23/25 (92%)