DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wds and wsb2

DIOPT Version :9

Sequence 1:	NP_001245503.1	Gene:	wds / 53428	FlyBaseID:	FBgn0040066	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001230313.1	Gene:	wsb2 / 100307075	ZFINID:	ZDB-GENE-081104-26	Length:	406	Species:	Danio rerio

Alignment Length:	332	Identity:	85/332 - (25%)
Similarity:	140/332 - (42%)	Gaps:	68/332 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SSNSSASNKSSLSVK-PNYTLKFTLAGHTKAVSAVKFSPNGE-WLASSSADKLIKIWGAYDGKFE 107
            |:.|..|.:..|:.: ..:.|.|.....|:..||.:.....| .||:...:..|::|....|..:
Zfish    69 SAESCCSKEKILNCRFLVWALAFGPCTSTRVDSAHQHRREHELLLAAGLHNGSIQVWLVSTGNLQ 133

  Fly   108 KTISGHKLGISDVAWSSDSRL-LVSGSDDKTLKVWEL-STGKSLKTLKGHSNYVFCCNFNPQSNL 170
            .|::||:..:.|:.::.:..| |:|.|.||||::|:| ..|.|...|:|.:.:||.|..:|.|::
Zfish   134 FTLTGHQAPVRDLVFAPNGSLTLISASRDKTLRIWDLGKKGASPHVLRGPNYWVFRCAVSPDSSV 198

  Fly   171 IVS-GSFDESVRIWDVRTGKCLKTLP-AHSDPVSAVHFNRDGSLIVSSSYDG----LCRIWDTAS 229
            |.| .:.|..|.:|.:|:...:|.|. .|...:::..|::||:|:..:||..    ...:||..:
Zfish   199 IASVCNLDSKVYLWSLRSYTFMKHLTYDHERTMASCDFSQDGALLAIASYHSNTGWWLDLWDPYT 263

  Fly   230 GQCLKTLID-------DDNPPVSFVKFSPNGKYILAATLD-NTLKLWDYSKGKCLKTYTGHKNEK 286
            ...|..:.|       .||...| :.|||..  :|.|..| ..|::||..:.| |...|.|..
Zfish   264 ADLLTRVQDCEVCAYRSDNLLTS-LSFSPVA--LLLAFKDYRALQIWDVERDK-LVADTDHNR-- 322

  Fly   287 YCIFANFSVTGGKWIVSGSEDNMVYIWNLQSKEVVQKLQGHTDTVLCTACHPTENIIASAALEND 351
                     .||                                 :|.|.||...:||:..  .|
Zfish   323 ---------AGG---------------------------------VCCAFHPQGGVIATGC--RD 343

  Fly   352 KTIKLWK 358
            ..:|.||
Zfish   344 GHVKFWK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wds	NP_001245503.1	WD40	64..358	CDD:238121	79/310 (25%)
		WD40 repeat	75..112	CDD:293791	9/37 (24%)
		WD40 repeat	118..154	CDD:293791	14/37 (38%)
		WD40 repeat	159..195	CDD:293791	12/36 (33%)
		WD40 repeat	202..237	CDD:293791	9/38 (24%)
		WD40 repeat	244..280	CDD:293791	12/36 (33%)
		WD40 repeat	288..325	CDD:293791	2/36 (6%)
		WD40 repeat	331..357	CDD:293791	8/25 (32%)
wsb2	NP_001230313.1	WD40	<37..352	CDD:225201	85/332 (26%)
		WD40	37..350	CDD:295369	83/330 (25%)
		WD40 repeat	41..74	CDD:293791	2/4 (50%)
		WD40 repeat	80..138	CDD:293791	13/57 (23%)
		WD40 repeat	143..181	CDD:293791	13/37 (35%)
		WD40 repeat	188..224	CDD:293791	11/35 (31%)
		WD40 repeat	231..279	CDD:293791	10/47 (21%)
		WD40 repeat	284..309	CDD:293791	9/27 (33%)
		WD40 repeat	325..349	CDD:293791	9/58 (16%)
		SOCS	355..391	CDD:295349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810