Protein Alignment ACXB and Adcy5

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_072122.2
• Gene: Adcy5 / 64532
• RGDID: 71014
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1144
• Identity: 303/1144 - (26%)
• Similarity: 522/1144 - (45%)
• Gaps: 222/1144 - (19%)

  Fly    36 LEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQK---KLIYYESLTAIVVLVAVPGI 97
            ||..|::|..||..|.||:...:.:.|   | |....|...:   :::|...|.|.|.::.:..:
  Rat   227 LERLYQRYFFRLNQSSLTMLMAVLVLV---C-LVMLAFHAARPPLQVVYLAVLAAAVGVILIMAV 287

  Fly    98 LSINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFKYH----WPLNTLYDVFVLCMIYM 158
            |...  .:|...|..:..::.|.   :|:.|.:..:|:...:..    |     :.||.:..||.
  Rat   288 LCNR--AAFHQDHMGLACYALIA---VVLAVQVVGLLLPQPRSASEGIW-----WTVFFIYTIYT 342

  Fly   159 FLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRI 223
            .||: .:|.|.|....:|.:::.:.::....|...:.::|.:     |.||...  |::|:....
  Rat   343 LLPV-RMRAAVLSGVLLSALHLAISLHTNAQDQFLLKQLVSN-----VLIFSCT--NIVGVCTHY 399

  Fly   224 MNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIV 288
            ..:...|.:|.:..:.::..:..::..||:..||.|:||..:|..::..|
  Rat   400 PAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADI--------------- 449

  Fly   289 VNARRTENFM----AIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQ 349
             ||:: |:.|    .||.|.:||||:||:..:|.|.:..|.::||..|::|:.|||..|:.....
  Rat   450 -NAKQ-EDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 512

  Fly   350 RIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIG 414
            |||.||||||||:||.||..|||...|.:|:.||..|..||....::::||:|:|||.:..||:|
  Rat   513 RIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLG 577

  Fly   415 QAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTT 479
            ..|.|:|:|..||.:||.:||.||.|.:|::..||:.|| .:|.|.||.. .:.:..|::..:.|
  Rat   578 LRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLN-GDYEVEPGCG-GERNAYLKEHSIET 640

  Fly   480 YL-------------LTAAPSRNSVRSV--DAVHSYAEIDI-NALGASRKSPILRPTLMSDELRE 528
            :|             :.|..:|....|:  :..|..||... |.||.::.|             :
  Rat   641 FLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVS-------------K 692

  Fly   529 EFKKMPVGGF-NIRSPCCRDNSN-DEKVNHGLGMFCVAFKDSSLEWSYLHK-------PDFILKY 584
            |.|:|   || :.:....::::| :::|:..||....|.....|...::.|       ||...||
  Rat   693 EMKRM---GFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKY 754

  Fly   585 SVLLAWGIGCCLIYIQIVNDKFTICVEC-----IVIDMVVFTFLTSLLFISWFKKVCW------- 637
            |              :.|:|:|...|.|     :.|..|..|.:...||:..|...|:
  Rat   755 S--------------KQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVV 805

  Fly   638 -----WRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVT-IYMSIVASYYLLISTILLNCDKNQY 696
                 :.||:........:|.|:.:..:......|..:| :::|...:.::..|..|:.|...::
  Rat   806 FISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKNLVGCLAEEH 870

  Fly   697 ELDV-------INSKLYHYDIVTD---------NCFNPWVFTDMISLIVGVSYTFARIPFALKML 745
            .:.|       :....::|.:..:         ||..|..||..:.|.:.....|.:|....|::
  Rat   871 NITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLV 935

  Fly   746 ITCCATVAYLVIVFFQYSFIFEH-----SATTTPFMKAELAHC--------------LRVCMMLL 791
            :.....:.|::||......:|::     :|....|.....:.|              :.:.:.:|
  Rat   936 LMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVL 1000

  Fly   792 TMYAKERQSEFNTKINF--KINQDLQGKQKAADIT--NKSIIILLTNILPSHVVEVYL-DSVANH 851
            .:|...:|.|...:::|  |: |..:.|::..::.  |:.   ||.||||..|...:| ....|.
  Rat  1001 ALYLHAQQVESTARLDFLWKL-QATEEKEEMEELQAYNRR---LLHNILPKDVAAHFLARERRND 1061

  Fly   852 ELYYENYKMVSVMFAMLINFQ---MDLPS-------LRVLNDIITEFDRLLNAYKEYYVVEKIKV 906
            ||||::.:.|:||||.:.||.   ::|.:       ||:||:||.:||.:::. ..:..:||||.
  Rat  1062 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE-DRFRQLEKIKT 1125

  Fly   907 VGCTYMAACGL-DFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMR 970
            :|.|||||.|| |.|..|:   .:||..                          .:..||:.||.
  Rat  1126 IGSTYMAASGLNDSTYDKA---GKTHIK--------------------------ALADFAMKLMD 1161

  Fly   971 VLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGH 1035
            .:...|        :.:.:..::.||::.|.::|||:||.:|.||||||.||:||||:|||:|..
  Rat  1162 QMKYIN--------EHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDR 1218

  Fly  1036 IHVTQETANIL--EQFDIMCMYRGMTFVKGRGEIPTYFV 1072
            |.||.:...:|  ..:.:.|  ||:..|||:||:.|||:
  Rat  1219 IQVTTDMYQVLAANTYQLEC--RGVVKVKGKGEMMTYFL 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	53/246 (22%)
		CYCc	249..459	CDD:214485	86/213 (40%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	80/202 (40%)
		CYCc	825..1047	CDD:214485	81/235 (34%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	80/231 (35%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	57/270 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..196
		Guanylate_cyc	461..634	CDD:306677	76/174 (44%)
		DUF1053	669..761	CDD:399378	25/121 (21%)
		Guanylate_cyc	1063..1257	CDD:306677	81/233 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910