DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and gucy2ca

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	984	Identity:	218/984 - (22%)
Similarity:	348/984 - (35%)	Gaps:	333/984 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 RHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAI 300
            :..:.:|..|...|.:..|.|..|            :|...::.||::....:....|..|.:.:
Zfish   192 KDNYTEECFWYINALEAPSALFSS------------NISREMLRSESELSTALKRKDRHSNIIVM 244

  Fly   301 QIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLG 365
            ...||      |:  ||.........::|.:|.|||                  .:.|    ...
Zfish   245 CGTPD------DI--YTIKKNNTVPSQVVFILIDLY------------------NEGY----RTN 279

  Fly   366 EADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDI- 429
            |:.|.|.|..:.|.:....|.......|          ::.|:..|  |..||  |..| |.|:
Zfish   280 ESSPAHMRNVLVLTMHSFRNYSSNSVWR----------NNTTVSIG--GYYKL--DSSG-DRDLN 329

  Fly   430 ANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSV 494
            .:.:..||...|     |||.|.:.::..    |:|..|.|.|             |...|....
Zfish   330 LSVVYTTGSYKY-----RTLFSFDTSQNR----TKVKDSSPDL-------------PWDRSQLPR 372

  Fly   495 DAVHSYAEID---INALGASRKSPILRPTLM-------SDELREEFKKMPVGGFNIRSPCCRDNS 549
            |. |:..||.   :..||.|    ::..|::       :..:|.:.||......::.:|.
Zfish   373 DK-HTGMEIQEIMMIVLGLS----VVLATVIAFILYRQNRRVRFDQKKWSHISSSLITPL----- 427

  Fly   550 NDEKVNHGLGMFCVAFK---DSSL--EWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTIC 609
             |:|..:.:.:.....|   :|||  :..|..|| .|||              .::..:..||
Zfish   428 -DDKERNYISLTIDEDKKGDNSSLIRKGRYDKKP-VILK--------------ELRNTDGNFT-- 474

  Fly   610 VECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYG--RVSCKLFKIWE------------ 660
                 .|..:  .|.:||.|.::          |.::.||  |..|.:|.::|
Zfish   475 -----DDQRI--ELNALLRIDYY----------NLTKFYGTVRFDCGVFGVFEFCERGSLRYVLD 522

  Fly   661 -RIQH---SFV---LRVTIYMSIVASY-YLLISTILLNCDKNQYELDVINSKLYHYDIVTDN--- 714
             :|.:   ||:   .|:::...|.... ||..|.:            .::.:|...:.|.||
Zfish   523 DKISYPDASFMDLEFRISVMYDIAKGMSYLHSSNV------------GVHGRLKSTNCVVDNRMV 575

  Fly   715 -------C---FNP----WVFTDMISLIVGVS-----YTFARI---------PFALKMLITCCAT 751
                   |   .:|    |...:.:. :.|:|     |:||.|         ||.    .:||:.
Zfish   576 VKITDFGCNTILSPGKDLWTAPEHMR-VEGISQKGDVYSFAIISQEIILRKSPFH----TSCCSD 635

  Fly   752 VA---YLVIV-----FFQYSFIFEHSATTTPFMKAELAHCLRVC--------------------- 787
            :|   |||..     .|:....||....|    :|||...::.|
Zfish   636 MAEKLYLVQYPRGPNVFRPDLSFEGVGET----EAELFVLIKSCWEEDPEKRPDFKRIEGALGKI 696

  Fly   788 ----------------MMLLTMYAK--ERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTN 834
                            :..|.||::  |...|..|.: :|..:|      .||..|       ..
Zfish   697 FSNLHNQANASYMDNLIRRLQMYSRNLEHLVEERTAL-YKAERD------RADQLN-------FM 747

  Fly   835 ILPSHVVEVYLDS-VANHELYYENYKMVSVMFAMLINF------QMDLPSLRVLNDIITEFDRLL 892
            :||..||....:: ....|||.|    |::.|:.::.|      ...:..:.:||||...||.:|
Zfish   748 LLPGPVVRSLKETGRVEPELYDE----VTIYFSDIVGFTTICHHSTPMEVVDMLNDIYKNFDSIL 808

  Fly   893 NAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEV 957
                :::.|.|::.:|..||.|.||                             .:...|.|
Zfish   809 ----DHHDVYKVETIGDAYMVASGL-----------------------------PRCNGNRH--- 837

  Fly   958 AFIMTTFALDLMRVLSVCN-KAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPV 1021
            |..:...|||::..:.... :...|.|.       .|.|||.:|...|||||...|.|.::|:.|
Zfish   838 AVDICLMALDILEFMGTFQLRHLPGIPL-------WIRIGIHSGPCAAGVVGNKMPRYCLFGDTV 895

  Fly  1022 NMASRMESTGLPGHIHVTQETANILEQFD--IMCMYRGMTFVKGRGEIPTYFV-GIDDNLKFLPS 1083
            |.||||||||||..|||::.|..||::.|  ..|..||.||:||:|:..||:: |:......||:
Zfish   896 NTASRMESTGLPLRIHVSESTIKILQRTDCEFECERRGETFLKGKGKEMTYWLTGVTGQKYSLPT 960

  Fly  1084 NVKKNNMSK 1092
            .....|..:
Zfish   961 PPTVENFQR 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	7/39 (18%)
		CYCc	249..459	CDD:214485	43/210 (20%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	39/186 (21%)
		CYCc	825..1047	CDD:214485	65/229 (28%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	71/227 (31%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	50/251 (20%)
		PKc_like	428..698	CDD:304357	63/324 (19%)
		Pkinase_Tyr	451..689	CDD:285015	57/292 (20%)
		CYCc	736..929	CDD:214485	70/252 (28%)
		Guanylate_cyc	763..950	CDD:278633	72/233 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000