Protein Alignment ACXB and gucy2ca

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_073799927.1
• Gene: gucy2ca / 572052
• ZFINID: ZDB-GENE-091118-67
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1016
• Identity: 222/1016 - (21%)
• Similarity: 356/1016 - (35%)
• Gaps: 351/1016 - (34%)

  Fly   236 RHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAI 300
            :..:.:|..|...|.:..|.|..|            :|...::.||::....:....|..|.:.:
Zfish   192 KDNYTEECFWYINALEAPSALFSS------------NISREMLRSESELSTALKRKDRHSNIIVM 244

  Fly   301 QIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLG 365
            ...||      |:  ||.........::|.:|.|||                  .:.|    ...
Zfish   245 CGTPD------DI--YTIKKNNTVPSQVVFILIDLY------------------NEGY----RTN 279

  Fly   366 EADPDHARMAVSLGISMIANIQEVRAHR----ALDIDMRIGVHSGTLLAGVIGQAKLQ------- 419
            |:.|.|.|..:.|.:....|.......|    ||: |..:|.|...:|.|...:..||
Zfish   280 ESSPAHMRNVLVLTMHSFRNYSSNSVWRNNTTALN-DYVVGYHDAVVLFGNAMRNNLQRIKQQQG 343

  Fly   420 --------------YDIWGPDVDIANRLEATG----KPGYVHVSG----RTLSSLNVAEYTVFPG 462
                          |.|.|     ..:|:::|    ....|:.:|    |||.|.:.::..
Zfish   344 LSDNIDPPFRNMSFYGIGG-----YYKLDSSGDRDLNLSVVYTTGSYKYRTLFSFDTSQNR---- 399

  Fly   463 TEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEID---INALGASRKSPILRPTLM-- 522
            |:|..|.|.|             |...|....|. |:..||.   :..||.|    ::..|::
Zfish   400 TKVKDSSPDL-------------PWDRSQLPRDK-HTGMEIQEIMMIVLGLS----VVLATVIAF 446

  Fly   523 -----SDELREEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFK---DSSL--EWSYLHK 577
                 :..:|.:.||......::.:|.      |:|..:.:.:.....|   :|||  :..|..|
Zfish   447 ILYRQNRRVRFDQKKWSHISSSLITPL------DDKERNYISLTIDEDKKGDNSSLIRKGRYDKK 505

  Fly   578 PDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVE 642
            | .|||              .::..:..||       .|..:  .|.:||.|.::
Zfish   506 P-VILK--------------ELRNTDGNFT-------DDQRI--ELNALLRIDYY---------- 536

  Fly   643 NDSRKYG--RVSCKLFKIWE-------------RIQH---SFV---LRVTIYMSIVASY-YLLIS 685
            |.::.||  |..|.:|.::|             :|.:   ||:   .|:::...|.... ||..|
Zfish   537 NLTKFYGTVRFDCGVFGVFEFCERGSLRYVLDDKISYPDASFMDLEFRISVMYDIAKGMSYLHSS 601

  Fly   686 TILLNCDKNQYELDVINSKLYHYDIVTDN----------C---FNP----WVFTDMISLIVGVS- 732
            .:            .::.:|...:.|.||          |   .:|    |...:.:. :.|:|
Zfish   602 NV------------GVHGRLKSTNCVVDNRMVVKITDFGCNTILSPGKDLWTAPEHMR-VEGISQ 653

  Fly   733 ----YTFARI---------PFALKMLITCCATVA---YLVIV-----FFQYSFIFEHSATTTPFM 776
                |:||.|         ||.    .:||:.:|   |||..     .|:....||....|
Zfish   654 KGDVYSFAIISQEIILRKSPFH----TSCCSDMAEKLYLVQYPRGPNVFRPDLSFEGVGET---- 710

  Fly   777 KAELAHCLRVC-------------------------------------MMLLTMYAK--ERQSEF 802
            :|||...::.|                                     :..|.||::  |...|.
Zfish   711 EAELFVLIKSCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYMDNLIRRLQMYSRNLEHLVEE 775

  Fly   803 NTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYLDS-VANHELYYENYKMVSVMFA 866
            .|.: :|..:|      .||..|       ..:||..||....:: ....|||.|    |::.|:
Zfish   776 RTAL-YKAERD------RADQLN-------FMLLPGPVVRSLKETGRVEPELYDE----VTIYFS 822

  Fly   867 MLINF------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSK 925
            .::.|      ...:..:.:||||...||.:|    :::.|.|::.:|..||.|.||
Zfish   823 DIVGFTTICHHSTPMEVVDMLNDIYKNFDSIL----DHHDVYKVETIGDAYMVASGL-------- 875

  Fly   926 FGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCN-KAYAGRPFDRALS 989
                                 .:...|.|   |..:...|||::..:.... :...|.|.
Zfish   876 ---------------------PRCNGNRH---AVDICLMALDILEFMGTFQLRHLPGIPL----- 911

  Fly   990 TGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFD--IM 1052
              .|.|||.:|...|||||...|.|.::|:.||.||||||||||..|||::.|..||::.|  ..
Zfish   912 --WIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTGLPLRIHVSESTIKILQRTDCEFE 974

  Fly  1053 CMYRGMTFVKGRGEIPTYFV-GIDDNLKFLPSNVKKNNMSK 1092
            |..||.||:||:|:..||:: |:......||:.....|..:
Zfish   975 CERRGETFLKGKGKEMTYWLTGVTGQKYSLPTPPTVENFQR 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	48/248 (19%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	43/218 (20%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	71/227 (31%)
gucy2ca	XP_073799927.1	None