Protein Alignment ACXB and adcy1b

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_073776301.1
• Gene: adcy1b / 569499
• ZFINID: ZDB-GENE-100805-1
• Length: 1121
• Species: Danio rerio
• Alignment Length: 1204
• Identity: 306/1204 - (25%)
• Similarity: 496/1204 - (41%)
• Gaps: 356/1204 - (29%)

  Fly    31 CKELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVP 95
            |.|  ||..:::|  ||.:........|.:.:::.|.|     |..:.|:   |.|.:.|.....
Zfish    31 CAE--LEALFRRY--RLKLEQTATLKALSVLILLSCSL-----SLLELLL---SGTGLSVAQGSH 83

  Fly    96 GILSINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQI----------LVFHFKYH--------- 141
            .:.|:.|                 :|.:||..|...|:          |:|.|.:.
Zfish    84 PVHSVLF-----------------ISLFIVTNVQYLQVTQLQQIAHLSLLFGFTFAVPCCPLPQV 131

  Fly   142 ----------WPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISE 196
                      |||..|  .||   .|..||:.:  |.|||        .||.:           .
Zfish   132 SRAAGPEQGVWPLLLL--TFV---AYCLLPVRT--GLALL--------FGLLL-----------P 170

  Fly   197 VVHDLDT--------------ICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLR 247
            :.|.|.|              :..:...:.|.|:.|:|.||:.:...|.:||.....::|.:.:.
Zfish   171 LAHTLITASALPDNTQRLWRSLVANTLLFTGVNVSGLFVRILTERAQRKAFLQARNCIEERLRME 235

  Fly   248 QARQQESMLLDSILPPQIAKPIQQSI---KERIMLSETDSDRIVVNARRTENFMAIQIHPDVSIL 309
            ...:::..||.|:||..:|..:::..   .|||.                 :.:.||.|.:||||
Zfish   236 DENEKQERLLMSLLPRNVAMEMKEDFLKPPERIF-----------------HKIYIQRHDNVSIL 283

  Fly   310 YADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARM 374
            :||:|.:|.|.:..|.::|||:|::|:|:||..|:....:|||.||||||||:||.:...|||..
Zfish   284 FADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHC 348

  Fly   375 AVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKP 439
            .|.:|:.||..|..|.....:|::||:|:|:|.:|.||:|..|.|||:|..||.:||.:||.|.|
Zfish   349 CVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLP 413

  Fly   440 GYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSR--------NSVRS--- 493
            |.||::..||..|| .:|.|.||.. .:....|.|..:.|:.:..:..|        :.::.
Zfish   414 GKVHITRSTLECLN-GDYEVEPGNG-RERHAFLLKHDIETFFIVPSHRRKIFPGLILSDIKPAKK 476

  Fly   494 ----------VDAVHS----YAEIDINAL-----GASRKSPILRPTLMSDELREEFKKMPVGGFN 539
                      |..:|.    .|||..:.:     |..|:  :||..  .::||.
Zfish   477 MKFKTVCYLLVQLMHCRKMFKAEIPFSNVMNCEDGDKRR--VLRSA--PEKLRN----------- 526

  Fly   540 IRSP---CCRDNSNDEKVNH----------------GLGMFCVAFKDSSLEWSYLHKPDFILKY- 584
             |:|   ....:|...:||.                .|....:.::||..|..|....|   :|
Zfish   527 -RTPTTASAPQSSPGTRVNRYINRLIEARQTESDTADLNYLTLMYRDSERERRYHQLND---EYF 587

  Fly   585 ------SVLLAWGIGCCLIYIQIVNDKFTI------CVECIVIDMVVFTFLTSLLFISWFKKVCW 637
                  |:||...:|  .:|:.|:.....:      |: |.::..:::..:|
Zfish   588 TGAVVLSLLLVVLLG--FLYLLIIPQGTVVLVLLVFCI-CFLVVCIMYLHIT------------- 636

  Fly   638 WRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVIN 702
                        ||.|  |.....||    :|..:.:.||...|.:....::.|
Zfish   637 ------------RVQC--FPGCLTIQ----IRTALCVFIVLLIYAVAQACVVGC----------- 672

  Fly   703 SKLYHYDIVTDNCFNPWVFTD-------MISLIVGVSYTFARIPFA-LKMLITCCATVAYLVIVF 759
                          .||::..       :|....|::.|.|.:|.| .:....||......:.:|
Zfish   673 --------------MPWLWPSNSTRSIVIIDAAAGLNRTMAELPCAGAQYAFLCCMLGTLSMALF 723

  Fly   760 FQYSFI---------------------FEHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFN 803
            .:.|:|                     |..::.........|...|.:.:....:....||.:..
Zfish   724 LRVSWIPKMILLLLLLVLYITILELSGFRRASGWALLSVRGLEPLLSLLLFSTAVALHSRQLDLK 788

  Fly   804 TKINF----KINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL--------DSVANHELYYE 856
            .:::|    :..::..|.:| ..:.||.|   |.|:||.||.:.:|        .|..:.:|||:
Zfish   789 LRLDFLWATQAEEERDGMEK-VKLDNKRI---LFNLLPVHVAQHFLLSNPRNMVRSSEHQDLYYQ 849

  Fly   857 NYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYV-VEKIKVVGCT 910
            :|..|.|:||.:.||          .|.:..||:||:||.:||.|::  ||.|. :||||.:|.|
Zfish   850 SYAQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMD--KECYKDIEKIKTIGST 912

  Fly   911 YMAACGLDFTL-AKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSV 974
            ||:|.||..|: .|:|..:.||.|                          .:..||:::..||..
Zfish   913 YMSAVGLVPTIGTKAKKSTATHLS--------------------------TIADFAIEMFDVLDE 951

  Fly   975 CNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVT 1039
            .|.        ::.:...:.:||:.|.::|||:||.:|.||||||.||:||||:|||:||.|.||
Zfish   952 INY--------QSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVPGKIQVT 1008

  Fly  1040 QETANILE-QFDIMCMYRGMTFVKGRGEIPTYFV 1072
            ::...:|: .:|:||  ||...|||:|::.|||:
Zfish  1009 EDVYRLLQNNYDLMC--RGNVSVKGKGQMLTYFL 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	121/412 (29%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	81/185 (44%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	86/231 (37%)
adcy1b	XP_073776301.1	None