DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and adcy7

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	1209	Identity:	325/1209 - (26%)
Similarity:	533/1209 - (44%)	Gaps:	295/1209 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EYKKYQIRLMISYLT-----VFFPLF--------IFV-VVGCELCPWIFSEQKKLIYYESLTAIV 89
            :|:::.:.|.:|.:|     |.|..|        ||| |||..||.::              |:.
Zfish    28 QYRQFVLLLGLSIVTCATLLVLFFSFKLKAQNHGIFVGVVGGALCLFL--------------AVF 78

  Fly    90 VLVAVPGILSINFFESFVLRHRW-------------IMVFSSILSA--------------YIVVL 127
            |||...           .|..||             .|.|:.|.|.              ::.::
Zfish    79 VLVCTE-----------TLSQRWRTLLGLGVWATHLTMGFTFIFSTKSDLQIQPWDQVPFFLFII 132

  Fly   128 VDIFQILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDE 192
            :.::.:|.|...|...|:.:..:..:.::.::|.:     |.|.:..::...:...:.|
Zfish   133 ITVYTMLPFQMSYAVILSIISSLSHIIVLSVYLTV-----AQLHSNPITFQLLSNAVVF------ 186

  Fly   193 DISEVVHDLDTICVDIFHYLGFNLM-GIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESML 256
                                |..:| |||.:::.:..::.:|.|..:.|...|.|...::|:..|
Zfish   187 --------------------GCGIMVGIFHKVLMEKALKQTFQDTLRCLGIRMKLEIEKRQQENL 231

  Fly   257 LDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQI--HPDVSILYADVVNYTHL 319
            |.|:||..|:..::.:|.||....:.:..:.:|   |..||.::.:  |.:|||||||:|.:|.|
Zfish   232 LQSVLPVYISMKMKLAIMERCKCKDKEEQQRMV---RDNNFHSLYVKRHENVSILYADIVGFTRL 293

  Fly   320 TTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIA 384
            .:..:.::||.:|::|:|:||..|...:..|||.||||||||:||..:.|:||:..|.:|:.|..
Zfish   294 ASDCSPKELVLMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPVSLPNHAKNCVKMGLDMCE 358

  Fly   385 NIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTL 449
            .|::||....:||:||:|||||.:|.||||..|.|:|:|..||.:||.:|:.|.||.||::..||
Zfish   359 AIKQVREATGVDINMRVGVHSGNVLCGVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATL 423

  Fly   450 SSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLL---------TAAPS------------RNSVR- 492
            ..||.| |.|..|....: |..|::..:.|:|:         ..|||            |.|||
Zfish   424 KHLNKA-YEVEEGNGHLR-DTYLKELNIKTFLVIDPRSKDSSLMAPSITKPRVSDGLKMRASVRM 486

  Fly   493 -----SVDAVHSYAEID----------INALG-----ASRKSPILRPTLMSDELREEFK--KMPV 535
                 |..||..:|.:.          :|..|     ..|..|...|....:.|.|.|.  ..|:
Zfish   487 TRFLESWGAVKPFAHLQSREEFNTDAMVNGKGHCKDIPLRSVPTHNPDSFDESLEEPFSLPAPPL 551

  Fly   536 GGFNIRSPCCRDNSN----DEKVN----------------------HGLGMFCVAFKDSSLEWSY 574
            ..:|      |:.|.    ||:::                      .||.::... ||..:::..
Zfish   552 STYN------RNKSQKTKFDEELHDKMTTTINDLSSSKQWVKSEEISGLTLWFTK-KDLEMQYRT 609

  Fly   575 LHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTI-------CVECIVIDMVVFTFLTSL--LFIS 630
            :..|:|  ||.:..|..|..|:..||::..|..|       .:.|.::.::...|...:  :|..
Zfish   610 IEMPNF--KYYIGCATFIFICIFIIQMLVTKQRIELGLGFAVLACFLLLILCICFADHIQRMFPE 672

  Fly   631 WFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCD--- 692
            ..|...|...:.....|...|...|..:           .|..:.::|.:.|.:......||
Zfish   673 KLKSCTWLLALSKAVVKRPFVRILLATV-----------ATTVIVVIAMFELFLKKTDNLCDLLQ 726

  Fly   693 KNQYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIV-GVSYTFARIPFALKM-LITCCATVAYL 755
            :|....|....:|.:...:..||        :::||. ||   |.|:.|.||: .:...:.|:|.
Zfish   727 QNSSFADSARDELQYLPYLVYNC--------ILALIACGV---FLRVSFELKLAFLLIVSLVSYT 780

  Fly   756 VIVFFQ------YSFIF--EHS------ATTTPFMK-AELAHCLRVCMMLLTMYAKERQSEFNTK 805
            :|::.|      |:.:.  .||      ......|| .::..|:.:.:.|.||....||:|:..:
Zfish   781 IILYSQENLFSNYNCLLYTNHSCGDSLMVCKAGLMKHPKIMSCIYITLFLFTMLLISRQNEYCCR 845

  Fly   806 INFKI-NQDLQGKQKAADITNKSIIILLTNILPSHVVEVYLD-------------SVANH---EL 853
            .:|.: |::|..|:: .::......:||.|:||:||..:::.             |:.|.   :|
Zfish   846 QDFLLKNKNLADKEE-VELCENLNRLLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYKDL 909

  Fly   854 YYENYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVG 908
            ||::|..|.||||.:.:|          :..|..||:||:||.:||.||:..| :..|||||.:|
Zfish   910 YYKSYDCVCVMFASVPDFKEFYTECDINKEGLECLRLLNEIIADFDELLSKPK-FSGVEKIKTIG 973

  Fly   909 CTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLS 973
            .|||||.||                 |...||....:|.:..:..:      |..||:.|:..|.
Zfish   974 STYMAAAGL-----------------SGPPEQSNQDRERQNAQIGN------MVEFAIALIGKLD 1015

  Fly   974 VCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHV 1038
            ..|:        .:.:|..:.:||:.|.::|||:||.:|.||||||.||:||||||||..|.|.|
Zfish  1016 GINR--------HSFNTFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQV 1072

  Fly  1039 TQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGIDDN 1077
            |:||:.:|:.....|..||:..|||:||:.|:||..|.:
Zfish  1073 TEETSIVLQNLGYSCECRGLINVKGKGELKTFFVCTDSS 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	52/278 (19%)
		CYCc	249..459	CDD:214485	89/211 (42%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	81/196 (41%)
		CYCc	825..1047	CDD:214485	86/247 (35%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	87/228 (38%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	25/149 (17%)
		Guanylate_cyc	272..455	CDD:306677	81/184 (44%)
		DUF1053	487..613	CDD:310728	22/132 (17%)
		Guanylate_cyc	909..1106	CDD:306677	87/228 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880