Protein Alignment ACXB and adcy2a

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_692173.5
• Gene: adcy2a / 563724
• ZFINID: ZDB-GENE-061109-1
• Length: 1155
• Species: Danio rerio
• Alignment Length: 1143
• Identity: 320/1143 - (27%)
• Similarity: 527/1143 - (46%)
• Gaps: 233/1143 - (20%)

  Fly    57 PLFIF---VVVGCELCPWIFSEQKKLIYYES----LTAIVVLVAVPGILSINFFESFVLRHRWI- 113
            ||.:|   :|:|.  |..:.:     :::.|    ...:..::.||..|:| |...|||    :
Zfish   104 PLIVFLLLIVMGA--CLALLA-----VFFASGLDIEDHVAFVITVPTALAI-FLTIFVL----VC 156

  Fly   114 --MVFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLYD-----VFVLCMIYMFLPIPSIRGAALL 171
              .||..:|..:.:|:......:.:.|.:...:...:|     :|::.::|..||. |:|.|.:.
Zfish   157 IESVFKKLLRVFSLVIWGCLVAMGYLFMFFGGIICPWDQVSFFLFIIFVVYTMLPF-SMRDAIIA 220

  Fly   172 ATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDR 236
            :...:..:..:....|.|....:..:|..   |..::..::..|:.|.:.:.:.:..::.::.|.
Zfish   221 SVLTASSHTVVLSVCLSSTVSHVEPLVWQ---ILANVIIFICGNVAGAYHKHLMELALKQTYQDT 282

  Fly   237 HQFLKEEMWLR-QARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENF--M 298
            ...:|..:.|. :.||||.:|| |:||..||:.::..|.:|:...:..      ....|.||  :
Zfish   283 CNCIKSPIKLEFEKRQQERLLL-SLLPAHIARVMKAEIIQRLQGPKFG------QVENTNNFHNL 340

  Fly   299 AIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAG 363
            .:|.|.:|||||||:|.:|.|.:..:..:||.:|::|:|:||..|...:..|||.||||||||:|
Zfish   341 YVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSG 405

  Fly   364 LGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVD 428
            |.|:.|:||:..|.:|:.|...|::||....::|.||:|||||.:|.||||..|.|||:|..||.
Zfish   406 LPESLPNHAKNCVKMGLDMCEAIKKVRDATGVEISMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 470

  Fly   429 IANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYL------------ 481
            :||.:||.|.||.||::..||..||.| |.|..| ...:.||.|::..:.|||
Zfish   471 LANHMEAGGVPGRVHITSETLEHLNGA-YKVEDG-HGQERDPYLKEHGVITYLVINPKVERKSPQ 533

  Fly   482 --------LTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPIL--RPTLMSDELREEFKKMPVG 536
                    :..|..|.|||....:.|:        ||::....|  |.::.::..:.....:|:|
Zfish   534 HYYRPRHTIDGAKMRASVRMTRYLESW--------GAAKPFANLHHRDSMTNENGKINTADVPIG 590

  Fly   537 GFNIRSPCCRDNSN----DEKVN-------------------HGLGMFCVAFKDSSLEWSYLHKP 578
            .::.:....|..|.    :|::|                   ..:....:.|.:.:||..|....
Zfish   591 QYHFQRRSERTKSQKKRFEEELNERMIRTFDGINSQKQWLKSEDIQRISLFFHNKALEKEYRATT 655

  Fly   579 DFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVC----WWR 639
            ....||.:..|..|..|:..:||:     :..:..::.:   :|..|.|.:|....||    :.:
Zfish   656 LPAFKYYITCACLIFFCIFIVQIL-----VLPKTAILGV---SFGMSFLILSVILLVCFIGHFLQ 712

  Fly   640 CVENDS-------RKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYL--------LISTI-- 687
            |.:..|       |..|.::.   |.|.||  :..:..|..:.|:|.:.:        |:.|:
Zfish   713 CKKTASASWVWILRSSGIIAS---KPWPRI--TLTMATTALILIMAVFNMFFIEDNLTLMETVYN 772

  Fly   688 -----LLN--------CDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIP 739
                 ||.        .|||.:.|                   |:.....|..::..| .|.||.
Zfish   773 TSNETLLQPDGQPIPYLDKNTFYL-------------------PYFIYSCILGLISCS-VFLRIN 817

  Fly   740 FALKMLITCCATVAYLVIV-------FFQYS-FIFEHSATTTPFMKAELAHCLRVCMML--LTMY 794
            :.|||||...|.|.|.||:       ..:|| |:::......|.:..:|.....|.:.:  :|:.
Zfish   818 YELKMLIMLTAVVLYSVIILQTHASLLDEYSKFLYKTEVIERPGVLKDLKTMGSVSLFIFFITLL 882

  Fly   795 AKERQSEFNTKINF----KINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELY 854
            ...||:|:..:::|    |..::.:..:...::..    :||.|:||:||.|.:| .:..|.:||
Zfish   883 VLARQNEYYCRLDFLWKNKFKKECEEIETMENLNR----VLLENVLPAHVAEHFLARNWKNEDLY 943

  Fly   855 YENYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGC 909
            :::|.:|.||||.:.:|          :..|..||:||:||.:||.||:..| :..|||||.:|.
Zfish   944 HQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPK-FSGVEKIKTIGS 1007

  Fly   910 TYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTE--NDHDEVAF---IMTTFALDLM 969
            |||||.||:.|                           .|.|  .:||....   .|..||..|:
Zfish  1008 TYMAATGLNAT---------------------------PGPEYTQEHDRQYMHIGTMVEFAFALV 1045

  Fly   970 RVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPG 1034
            ..|.|.||        .:.:..::.:||:.|.:.|||:||.:|.||||||.||:||||:|||:.|
Zfish  1046 GKLDVINK--------HSFNDFKLRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRMDSTGVLG 1102

  Fly  1035 HIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFV 1072
            .|.||:||:.||:.....|..||:..|||:||:.||||
Zfish  1103 KIQVTEETSCILQTLGYTCSCRGIINVKGKGELKTYFV 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	120/377 (32%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	86/205 (42%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	89/233 (38%)
adcy2a	XP_692173.5	AcyC	104..529	CDD:441717	139/449 (31%)
		Guanylate_cyc	340..524	CDD:425528	86/185 (46%)
		Adcy_cons_dom	554..659	CDD:461877	15/112 (13%)
		Guanylate_cyc	942..1141	CDD:425528	91/235 (39%)