Protein Alignment ACXB and adcy6b

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_002666536.2
• Gene: adcy6b / 560807
• ZFINID: ZDB-GENE-090127-2
• Length: 1174
• Species: Danio rerio
• Alignment Length: 1154
• Identity: 308/1154 - (26%)
• Similarity: 518/1154 - (44%)
• Gaps: 235/1154 - (20%)

  Fly    30 KCKELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAV 94
            |.|...||..|::|..||..|.||:...:.: ||.|..|..........:.|     |.|:.||:
Zfish   138 KFKSAKLERLYQRYFFRLNQSSLTMLMGVLV-VVCGVMLAFHCVQGPPDVAY-----ASVLSVAM 196

  Fly    95 PGILSI-------NFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLYDVFV 152
            ...|::       .|.:.::    ||:   |.|...::|:|.:|.:|:.. ....|....:.||.
Zfish   197 GLFLTLMVVCNRNGFHQDYM----WIV---SYLVMGVLVVVQVFGLLMVD-PPSMPEGIWWTVFF 253

  Fly   153 LCMIYMFLPIPSIRGAALLATSVSLMYIGL---------FIYFLKSDDEDISEVVHDLDTICVDI 208
            :.:||..||: .:|.|.:....:|.::|.:         |:|                ..:|.:.
Zfish   254 IYIIYTLLPV-RMRAAVITGAVLSTIHIVMAWRFNLEDSFLY----------------KQLCANA 301

  Fly   209 FHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSI 273
            ..:|..|::||......:...|.:|.:...:::..:.|::..||:..||.|:||..:|..::..|
Zfish   302 MIFLCTNIIGICTHYPAEVSQRQAFKETRGYIQARIHLQRENQQQERLLLSVLPRHVAMEMKADI 366

  Fly   274 ---KERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDL 335
               ||.:|..:                :.||.|.:||||:||:..:|.|.:..|.::||..|::|
Zfish   367 NAKKEDMMFHK----------------IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNEL 415

  Fly   336 YGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMR 400
            :.|||..|......|||.||||||||:||.|...|||...|.:|:.||..|..||....::::||
Zfish   416 FARFDKLAWENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMR 480

  Fly   401 IGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEV 465
            :|:|||.:..||:|..|.|:|:|..||.:||::||.||.|.:|::..||..|| .:|.|..|...
Zfish   481 VGIHSGRVHCGVLGLRKWQFDVWSNDVTLANQMEAGGKAGRIHITKATLQYLN-GDYEVEAGFGG 544

  Fly   466 AQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDEL---- 526
            .::..:......|.::|..:..|...:::.|....|.        :..|..|.|..:.|..
Zfish   545 DRNAYLNNNNIETFFVLGCSQKRKEEKAMMAKMQRAR--------ANSSEGLMPRWVPDRSFSRT 601

  Fly   527 --REEFKKMPVGGFNIR-SPCCRDNSN-DEKVNHGLG-----------------MFCVAFKDSSL 570
              .:.|::|.:...:.: :.|.::..| :::|:..||                 .|.:.|:...|
Zfish   602 KDSKVFRQMGIDEASSKDNRCAQEALNPEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQTPLL 666

  Fly   571 EWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKV 635
            |..|..|.|......|.....:.|.:::||||....|..:  :.:.:.:|..|..:|||     .
Zfish   667 EKKYSKKVDDRFGGYVACTLLVFCFIVFIQIVIFPHTPLM--LGLFITIFIILAHVLFI-----C 724

  Fly   636 CWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTI-----LLNCDKNQ 695
            ..:.||            |||.:..:.....:::..|..::|..:.:|:..|     :..||:..
Zfish   725 AIYSCV------------KLFPVTLQTVSKRIVQSRINSTLVGVFTILLLFISAFVNMFTCDRTD 777

  Fly   696 Y------ELDVINS----KLYHYDIVTDN-----------CFNPWVFTDMISLIVGVSYTFARIP 739
            .      .|::..|    .||:...:.::           |..|..||..:.|.:.....|..|.
Zfish   778 MLACVAGHLNISESVTLCLLYNLSGLAEDPFFLCLDQPSACPLPEYFTYSVLLTLLCCSVFLHIS 842

  Fly   740 FALKMLITCCATVAYLVIVFFQYSFIFEHS--ATTTPFMKA--ELAHC--------LRV------ 786
            ...|:::.....:.:|:::.:....:.:::  ..|...:.|  |..:|        |||
Zfish   843 SIGKLVLMLFIQICFLLLIEWPLVSLLDNADLLDTVDALYAFNETNYCQETVTKVSLRVSIPVIL 907

  Fly   787 CMMLLTMYAKERQSEFNTKINF--KINQDLQGKQKAADIT--NKSIIILLTNILPSHVVEVYL-D 846
            .:.:|.:|...:|.|...:::|  |: |..:.|::..::.  |:.   ||.||||..|...:| .
Zfish   908 TVFVLALYLHAQQVESTARLDFLWKL-QATEEKEEMEELQAYNRR---LLHNILPKDVAAHFLAR 968

  Fly   847 SVANHELYYENYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYVV 901
            ...|.||||::.:.|:||||.:.||          ...:..||:||:||.:||.:::..| |..:
Zfish   969 ERRNDELYYQSCECVAVMFASISNFSEFYTELEANNEGVECLRLLNEIIADFDEIISEEK-YKQL 1032

  Fly   902 EKIKVVGCTYMAACGL-DFTLAKSKFGSRTH----ASYSSEL-EQVLYRKESKGTENDHDEVAFI 960
            ||||.:|.|||||.|| |.|..|.   .|||    |.|:..| ||:.|       .|:|
Zfish  1033 EKIKTIGSTYMAASGLNDSTYDKE---GRTHILALADYAMRLREQMKY-------INEH------ 1081

  Fly   961 MTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMAS 1025
                                      :.:..::.||::.|.::|||:||.:|.||||||.||:||
Zfish  1082 --------------------------SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVAS 1120

  Fly  1026 RMESTGLPGHIHVTQETANILEQ--FDIMCMYRGMTFVKGRGEIPTYFV 1072
            ||:|||:|..|.||.:..::||.  :.:.|  ||:..|||:|::.|||:
Zfish  1121 RMDSTGVPDRIQVTTDLYHVLESKGYQLEC--RGLVKVKGKGDMTTYFL 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	59/258 (23%)
		CYCc	249..459	CDD:214485	84/212 (40%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	76/185 (41%)
		CYCc	825..1047	CDD:214485	85/238 (36%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	85/236 (36%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454	63/268 (24%)
		Guanylate_cyc	378..562	CDD:306677	75/184 (41%)
		DUF1053	590..677	CDD:310728	16/86 (19%)
		Guanylate_cyc	975..1169	CDD:306677	86/238 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910