DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and npr1a

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	315	Identity:	89/315 - (28%)
Similarity:	147/315 - (46%)	Gaps:	47/315 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 LKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVR-SSFLDRHQFLKEEMWLRQAR 250
            |:...||::| ..|...|.|    .|..|..|....|:::.:.| ..:.:..:.|.||.  .||.
Zfish   788 LRCWSEDVNE-RPDFSQIKV----LLRKNNCGYGSNILDNLLSRMEQYANNLEELVEER--TQAY 845

  Fly   251 QQE----SMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYA 311
            .:|    ..||..|||..:|:.:::.  |.:.....||                     |:|.::
Zfish   846 HEEKRKAEALLYQILPHSVAEQLKRG--EMVQAEAFDS---------------------VTIYFS 887

  Fly   312 DVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGL----GEADPDHA 372
            |:|.:|.|:...|..::|.:|:|||..||.....|.|.:::.:||.|..|:||    |:.   ||
Zfish   888 DIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKL---HA 949

  Fly   373 RMAVSLGISMIANIQEVR-AHRA-LDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEA 435
            |....:.::::..:...| .||. |.:.:|||:|||.:.|||:|....:|.::|..|:.|:|:|:
Zfish   950 REIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMES 1014

  Fly   436 TGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNS 490
            .|:...:|||..|.:.|.  |:..|. .|:.....:..|..|.||.|....|.|:
Zfish  1015 NGEALKIHVSEATRAVLQ--EFNCFQ-LELRGDVEMKGKGRMRTYWLLGEISSNN 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	24/93 (26%)
		CYCc	249..459	CDD:214485	64/219 (29%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	60/191 (31%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380
		ANF_receptor	66..421	CDD:279440
		PK_GC-A_B	540..814	CDD:270944	9/30 (30%)
		TyrKc	554..808	CDD:197581	7/24 (29%)
		HNOBA	<823..868	CDD:285003	13/46 (28%)
		CYCc	847..1032	CDD:214485	61/210 (29%)
		Guanylate_cyc	874..1060	CDD:278633	62/212 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900