Protein Alignment ACXB and adcy2b

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_005170095.1
• Gene: adcy2b / 557902
• ZFINID: ZDB-GENE-060503-69
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1152
• Identity: 318/1152 - (27%)
• Similarity: 525/1152 - (45%)
• Gaps: 227/1152 - (19%)

  Fly    71 WIF------SEQKKLIYYESLTAIVVLVAVPGILSINFFESFVLRHR--WIMVFSSILSAYIVV- 126
            |::      |:|..||.:   ..::|:.|...:|::.|.....:...  :||...:.|:.::.:
Zfish    79 WVYESYYRMSQQHPLIVF---LLLIVMGACLALLAVFFASGLDMEEHMAFIMTVPTTLAIFLAIF 140

  Fly   127 -----------LVDIFQILV--------FHFKYHWPLNTLYD-----VFVLCMIYMFLPIPSIRG 167
                       |:.:|.:|:        :.|.:...:...:|     :|::.::|..||. |:|.
Zfish   141 ILVCIESVFKKLLRLFSLLIWGCLVAMGYLFMFFGGIICPWDQVSFFLFIVFVVYTMLPF-SMRD 204

  Fly   168 AALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSS 232
            |.:.:...|..:..:....|.:..:.:..:|..   |..:|..::..|:.|.:.:.:.|..::.:
Zfish   205 AVIASVLTSSSHTLVLSICLSNTSDHMEALVWQ---ILANIIIFICGNVAGAYHKHLMDLALKQT 266

  Fly   233 FLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIM---LSETDSDRIVVNARRT 294
            :.|....:|..:.|...:.|:..||.|:||..||:.::..|.:|:.   .|:         |..|
Zfish   267 YHDTCNCIKSPIKLEFEKHQQERLLLSLLPAHIARVMKAEIIQRLKGPNFSQ---------AENT 322

  Fly   295 ENF--MAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDC 357
            .||  :.:|.|.:|||||||:|.:|.|.:..:..:||.:|::|:|:||..|......|||.||||
Zfish   323 NNFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDC 387

  Fly   358 YYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDI 422
            ||||:||.:...|||:..|.:|:.|...|::||....:||:||:|||||.:|.||||..|.|||:
Zfish   388 YYCVSGLPDPLLDHAKNCVKMGLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQYDV 452

  Fly   423 WGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQS-DPILQKQPMTTYL----- 481
            |..||.:||.:||.|.||.||:|..||..||.| |.|..|.  .|| |..|::..:.|||
Zfish   453 WSHDVTLANHMEAGGVPGRVHISSVTLEHLNGA-YKVEQGN--GQSRDSYLKEHGIVTYLVINPK 514

  Fly   482 ---------------LTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPIL--RPTLMSDELREE 529
                           :..|..|.|||....:.|:        ||::....|  |.::.::.....
Zfish   515 AEKRSPLLLSAIRPTMYGAKMRASVRMTQYLESW--------GAAKPFANLHHRDSMTNENGMIN 571

  Fly   530 FKKMPVGGFNIRSPCCRDNSN----DEKVN-------------------HGLGMFCVAFKDSSLE 571
            .:.:|:|.:|.:....|..|.    :|::|                   ..:....:.|.:.:||
Zfish   572 TRDVPLGQYNCQQRSERTKSQKKRFEEELNERIIRTIDGINSQKQWLKSEDIQRISLFFHNKALE 636

  Fly   572 WSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDM---VVFTFLTSLLFISWFK 633
            ..|........||.|..|..|..|:..:|::     :..:..|:::   :.|..|..:|.|.:..
Zfish   637 KEYRATTLPAFKYYVTCACLIFFCIFIVQVL-----VLPKTTVLEVSFGMAFLLLALILCICFAG 696

  Fly   634 KVCWWRCVENDSRKYGR-VSCKLFKI-----------WERIQHSFVLRVTIYMSIVASYYLL--- 683
            .:..|          |: .||.:.::           |.|:..:......|.:..|.:.:.|
Zfish   697 HILQW----------GKAASCTMPRLPSSSKVITNKPWIRLALTMATTALILVMAVFNMFFLGED 751

  Fly   684 ---ISTILLNCDKNQYELDVINSKL-YHYDIVTDNCFNPWVFTDMI-SLIVGV--SYTFARIPFA 741
               .||          .|::.||.: ..|..:|::..|.:.....| |.|:|:  ...|.||.:.
Zfish   752 RMVAST----------SLNISNSSMDGPYGQITNSSNNKFYLPYFIYSCILGLISCSVFLRINYE 806

  Fly   742 LKMLITCCATVAYLVIVFFQYSFIFEHSA-----TTTPFMKAELAH-----CLRVCMMLLTMYAK 796
            |||:|...|.|||.:|:...::.|.:..:     |..|.....|..     .:.:.:..:|:...
Zfish   807 LKMIIMLGAVVAYNIIILQTHASILDDYSMALYKTQQPDRPGVLKDLKTMGSISLFIFFVTLLVL 871

  Fly   797 ERQSEFNTKINF----KINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYLD-SVANHELYYE 856
            .||:|:..:::|    |..::.:..:...::..    :||.|:||:||.|.:|. :..|.:||::
Zfish   872 ARQNEYYCRLDFLWRNKFKKECEEIETMENLNR----VLLENVLPAHVAEHFLGRNWKNEDLYHQ 932

  Fly   857 NYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTY 911
            :|..|.||||.:.:|          :..|..||:||:||.:||.||:..| :..|||||.:|.||
Zfish   933 SYDTVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPK-FSGVEKIKTIGSTY 996

  Fly   912 MAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAF---IMTTFALDLMRVLS 973
            |||.||:.|               ..||...|          ||....   .|..||..|:..|.
Zfish   997 MAATGLNVT---------------PGLEYAQY----------HDRQYMHIGTMVEFAFALVGKLD 1036

  Fly   974 VCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHV 1038
            |.||        .:.:...:.:||:.|.::|||:||.:|.||||||.||:||||||||:.|.|.|
Zfish  1037 VINK--------HSFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQV 1093

  Fly  1039 TQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGIDDNLKFLPSNV 1085
            |:||..||:....||..||:..|||:|::.|:||..:........||
Zfish  1094 TEETNWILQTLGYMCSCRGIINVKGKGDLRTFFVHTEMTQSLSQGNV 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	44/237 (19%)
		CYCc	249..459	CDD:214485	94/214 (44%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	88/206 (43%)
		CYCc	825..1047	CDD:214485	90/235 (38%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	90/231 (39%)
adcy2b	XP_005170095.1	AC_N	<80..307	CDD:292831	42/233 (18%)
		CYCc	283..486	CDD:214485	93/212 (44%)
		Guanylate_cyc	328..512	CDD:278633	88/186 (47%)
		DUF1053	542..646	CDD:283888	16/111 (14%)
		CYCc	899..1106	CDD:214485	91/244 (37%)
		Guanylate_cyc	929..1128	CDD:278633	91/232 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880