DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and gucy1b2

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	854	Identity:	167/854 - (19%)
Similarity:	302/854 - (35%)	Gaps:	296/854 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 ENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYY 359
            |.||..:|:.|:             .|...|::..|:|       |:::...    :|..|:.::
Zfish    33 ETFMTYEIYDDI-------------ITLRLVQEACKML-------DVSSEVV----LKLFGEYFF 73

  Fly   360 CVAGLGEADPDHARMAVSLG---ISMIANIQEVRAHRALDID------MRI-GVHSGTLLAGVIG 414
            ....:...|    .|..:||   :..|.|:..:.::.||..:      .|: .:..|.:|.....
Zfish    74 SFCKMSGYD----TMLRTLGGNLVEFIENLDALHSYLALSYEAMNAPSFRVERMDDGRILLHYYS 134

  Fly   415 QAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVA---------EYTVFPGTEVAQSDP 470
            ..|..|.|      :...:||..|..:  .|..|::.||.:         |:.||   .:.|.:.
Zfish   135 DRKGLYHI------VPGIIEAVAKDFF--DSEVTMTILNQSEEDERTGKKEHVVF---HMVQKEK 188

  Fly   471 ILQKQPMT-------TYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSP--ILRPTLM--SD 524
            :.:::..|       ..|........::|.:.|  .||.:.   |...::||  ::|..:|  ..
Zfish   189 VTKRKAQTRQNNSEEEILEVKKDKEETMRRMKA--RYANLQ---LCPRKRSPWELVRSIVMLGQG 248

  Fly   525 ELREEF-----KKMPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFKDSSLEWSYLHKPDFILKY 584
            .||:.|     |.:.:               :|:.      ||.||     .:..:...|.::|:
Zfish   249 NLRQSFTPSYPKTLWI---------------EEQA------FCNAF-----PFHIVFDSDLVVKH 287

  Fly   585 SVLLAWGI-------GCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVE 642
            :     |:       |.....|:: ::.||     ||...|:|..
Zfish   288 T-----GVNIQKFVPGLQTAGIRL-DEYFT-----IVHPEVIFNI-------------------- 321

  Fly   643 NDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYH 707
                    .|.|.|     |...|||:....|             |....:||..|.:....::.
Zfish   322 --------QSIKKF-----INSQFVLKTRREM-------------LPEVQQNQPTLKLRGQMMWM 360

  Fly   708 YDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIV---FFQYSFIFEHS 769
            ..:   ||                            |:..|...:..|..:   ....:.|.:|.
Zfish   361 ESL---NC----------------------------MIYLCSPKLRSLQELEERGLHLADIAQHD 394

  Fly   770 ATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIII---- 830
            .|..                 |.:..::|.:|      .:::..|:.|::...|.::::.|
Zfish   395 TTRD-----------------LILLNQQRLAE------IELSNQLERKKEELRILSRNLEIEKQK 436

  Fly   831 ---LLTNILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLINFQ------MDLPSLRVLNDIIT 886
               ||..:||:||.....:   ...:....:|:.:::|:.::.|.      ..:..:.:||.:.:
Zfish   437 SEKLLYAMLPTHVANQLKE---GKRVEAGEFKVCTILFSDVVTFTNICAACEPIQIVNMLNAMYS 498

  Fly   887 EFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTE 951
            .||||.:.:..|    |::.:|..||...|:...       :.|||      |:|
Zfish   499 RFDRLTSIHNVY----KVETIGDAYMVVGGVPVP-------TNTHA------ERV---------- 536

  Fly   952 NDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDI 1016
                      ..|||.:............|:|.       :|.:|:.||.::|||||...|.|.:
Zfish   537 ----------ANFALGMRIAAREVTNPITGQPI-------QIRVGLHTGPVLAGVVGEKMPRYCL 584

  Fly  1017 WGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCM-YRGMTFVKGRGEIPTYFVGIDDNLKF 1080
            :|:.||.||||||.|:|.||||:..|.::::...|..| .||...|||:|.:.||         |
Zfish   585 FGDTVNTASRMESHGVPDHIHVSPFTFSVIKDKGIFEMAERGEIEVKGKGLMRTY---------F 640

  Fly  1081 LPSNVKKNN 1089
            |..|::|::
Zfish   641 LLKNLQKSD 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831
		CYCc	249..459	CDD:214485	34/182 (19%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	37/211 (18%)
		CYCc	825..1047	CDD:214485	59/234 (25%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	62/225 (28%)
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002	31/165 (19%)
		CAF-1_p150	<166..277	CDD:288454	24/144 (17%)
		HNOBA	269..453	CDD:285003	48/299 (16%)
		CYCc	432..618	CDD:214485	59/232 (25%)
		Guanylate_cyc	459..642	CDD:278633	63/235 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900