Protein Alignment ACXB and Adcy4

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_062158.2
• Gene: Adcy4 / 54223
• RGDID: 2034
• Length: 1072
• Species: Rattus norvegicus
• Alignment Length: 1150
• Identity: 306/1150 - (26%)
• Similarity: 514/1150 - (44%)
• Gaps: 244/1150 - (21%)

  Fly    56 FPLFI--FVVVGCEL--CPWIFSEQKKLIYYESLTAIVVLVAVPG---ILSINFFESFVLRHRWI 113
            :||.|  .|:|.|.:  .|.:.....:.:..:......||.|:.|   :|.:...|..:  .||.
  Rat    27 YPLLILLLVIVLCAIVALPAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQQL--QRWT 89

  Fly   114 MVFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLYD-----VFVLCMIYMFLPIPSIRGAA---L 170
            ...|.::.|.::.       |.:.|.:...:.:.:|     :|::..:|..||: .:|.||   :
  Rat    90 RPLSGLIWAALLA-------LGYGFLFTGGVVSAWDQVSFFLFIIFTVYAMLPL-GMRDAAAAGV 146

  Fly   171 LATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLD 235
            :::...|:.:||::.:......|:      |..:..:...:|..|::|.:.:.:.:..:|::|.:
  Rat   147 ISSLSHLLVLGLYLGWRPESQRDL------LPQLAANAVLFLCGNVVGAYHKALMERALRATFRE 205

  Fly   236 RHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAI 300
            ....|.....|...::.:..||.||||..:|:.::..|..|:...::.      ....|.||.::
  Rat   206 ALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQSS------RPENTNNFHSL 264

  Fly   301 QI--HPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAG 363
            .:  |..||:||||:|.:|.|.:..:.::||.:|::|:|:||..|...:..|||.||||||||:|
  Rat   265 YVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSG 329

  Fly   364 LGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVD 428
            |..:.||||...|.:|:.|...|:::|....:||:||:|||||::|.||||..|.|||:|..||.
  Rat   330 LPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVT 394

  Fly   429 IANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLL----------- 482
            :||.:||.|.||.||::|.||:.| ...|.| ...::...||.|::....|||:
  Rat   395 LANHMEAGGVPGRVHITGATLALL-AGAYAV-ERADMEHRDPYLRELGEPTYLVIDPWAEEEDEK 457

  Fly   483 -------------TAAPSRNSVRSVD---AVHSYAEIDINALGASRKSPI--------------L 517
                         |..||....|.::   |...:|.:......||..:|:              .
  Rat   458 GTERGLLSSLEGHTMRPSLLMTRYLESWGAAKPFAHLSHVDSPASTSTPLPEKAFSPQWSLDRSR 522

  Fly   518 RPTLMSDELREEFKKMPVGGFNIRSPCCRDNSNDE-KVNHGLGMFCVAFKDSSLEWSYLHKPDFI 581
            .|..:.|||.....|.    |.:....   ||..: |.:....:..:.|::..:|..|
  Rat   523 TPRGLHDELDTGDAKF----FQVIEQL---NSQKQWKQSKDFNLLTLYFREKEMEKQY------- 573

  Fly   582 LKYSVLLAWG-IGCCLIYIQIVNDKFTICVECIVIDMVV------------FTFLTSLLFISWFK 633
             :.|.|.|:. ...|...:.:.|  ||       |.|:|            .|||..||.:.
  Rat   574 -RLSALPAFKYYAACTFLVFLSN--FT-------IQMLVTTRPPALATTYSITFLLFLLLLF--- 625

  Fly   634 KVCW----WRCVENDSRKYGRVSCKLFKIWERIQHSFV-----LRVTI---------YMSIVASY 680
             ||:    .:||:...:...         |.......|     |||.:         .|::|:..
  Rat   626 -VCFSEHLTKCVQKGPKMLH---------WLPALSVLVATRPGLRVALGTATILLVFTMAVVSLL 680

  Fly   681 YLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCFN-PWVFTDMISLIVGVSYT---------- 734
            :|.:|:   :|.             :....|:...|| .|.....:.|| .:.|:
  Rat   681 FLPVSS---DCP-------------FLAPNVSSVAFNTSWELPASLPLI-SIPYSMHCCVLGFLS 728

  Fly   735 ---FARIPFALKMLITCCATVAYLVIVFFQYSF--------IFEHSATTTP--FMKAELAHCLRV 786
               |..:.|.||:|:.....||...:....:::        :::.|..:.|  ..:.:|...:..
  Rat   729 CSLFLHMSFELKLLLLLLWLVASCSLFLHSHAWLSDCLIARLYQGSLGSRPGVLKEPKLMGAIYF 793

  Fly   787 CMMLLTMYAKERQSEFNTKINF----KINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL-D 846
            .:...|:....||:|:..:::|    |:.|:.:..:...::|.    :||.|:||:||...:: .
  Rat   794 FIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTR----LLLENVLPAHVAPQFIGQ 854

  Fly   847 SVANHELYYENYKMVSVMFAMLINFQ----------MDLPSLRVLNDIITEFDRLLNAYKEYYVV 901
            :..|.:||:::|:.|.|:||.:.:|:          ..|..||:||:||.:||.||:..| :..|
  Rat   855 NRRNEDLYHQSYECVCVLFASIPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK-FSGV 918

  Fly   902 EKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESK-GTENDHDEVAFIMTTFA 965
            ||||.:|.|||||.||             :|:...:.:|...|..|. ||          |..||
  Rat   919 EKIKTIGSTYMAATGL-------------NATPGQDTQQDAERSCSHLGT----------MVEFA 960

  Fly   966 LDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMEST 1030
            :.|...|.|.||        .:.:...:.:|::.|.::|||:||.:|.||||||.||:|||||||
  Rat   961 VALGSKLGVINK--------HSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST 1017

  Fly  1031 GLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGID 1075
            |:.|.|.||:|||..|:.....|..||:..|||:|::.|||:..|
  Rat  1018 GVLGKIQVTEETARALQSLGYTCYSRGVIKVKGKGQLCTYFLNTD 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	47/234 (20%)
		CYCc	249..459	CDD:214485	87/211 (41%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	82/211 (39%)
		CYCc	825..1047	CDD:214485	86/233 (37%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	88/229 (38%)
Adcy4	NP_062158.2	AC_N	<115..246	CDD:292831	28/137 (20%)
		CYCc	219..422	CDD:214485	86/209 (41%)
		Guanylate_cyc	264..430	CDD:278633	76/167 (46%)
		DUF1053	479..580	CDD:283888	20/115 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..523		3/24 (13%)
		CYCc	824..1039	CDD:214485	88/250 (35%)
		Guanylate_cyc	861..1060	CDD:278633	89/230 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920