DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	419	Identity:	101/419 - (24%)
Similarity:	164/419 - (39%)	Gaps:	125/419 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 LVDIFQILVFH--FKYHWPLNTLYDVFVL------------------------C------MIY-- 157
            |:.:|.::..|  ..:|..|:.:..||||                        |      |||
Mouse   250 LLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLP 314

  Fly   158 -----MFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLM 217
                 :||..||:....      .|...||::     .|..:.:...||             .|:
Mouse   315 EADSILFLCSPSVMNLD------DLTRRGLYL-----SDIPLHDATRDL-------------VLL 355

  Fly   218 GIFFR-IMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSE 281
            |..|| ....|.......||.|.....  |...:::...||.|:|||.:|..::.
Mouse   356 GEQFREEYKLTQELEILTDRLQLTLRA--LEDEKKKTDTLLYSVLPPSVANELRH---------- 408

  Fly   282 TDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLT----VEKLVKVLHDLYGRFDMA 342
                :..|.|:|.:|         |:||::.:|.:....:...    ..|:|.:|:|||.|||..
Mouse   409 ----KRPVPAKRYDN---------VTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTL 460

  Fly   343 ASTFK---VQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALD---IDMRI 401
            ..:.|   |.:::.:||.|..|:||.|....|||....|.:.|:    |:.....:|   :.:.|
Mouse   461 TDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMM----EIAGQVQVDGESVQITI 521

  Fly   402 GVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVA 466
            |:|:|.::.|||||...:|.::|..|::.:|.|.||:.|          .:||:|||........
Mouse   522 GIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKG----------KINVSEYTYRCLMSPE 576

  Fly   467 QSDPIL------------QKQPMTTYLLT 483
            .|||:.            :|:||..:.|:
Mouse   577 NSDPLFHLEHRGPVSMKGKKEPMQVWFLS 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	39/188 (21%)
		CYCc	249..459	CDD:214485	61/219 (28%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	58/208 (28%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572
		HNOBA	207..406	CDD:311573	39/181 (22%)
		Guanylate_cyc	412..605	CDD:306677	61/215 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900