DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and Phlpp2

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	82/440 - (18%)
Similarity:	152/440 - (34%)	Gaps:	133/440 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 HYLGFNLMGI---FFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQ 271
            |.|.|:..|.   .:.:..:|:.           :.:.|.|||.:..|..:.::   .::....:
  Rat   248 HSLAFSSAGAQAQTYHVSFETLA-----------EYQRWQRQASKVVSQRISTV---DLSCYSLE 298

  Fly   272 SIKERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILY----ADVVNYTH----LTTTLTVEKL 328
            .:.|.:..|:   |...:|.|  .|||.::....:..||    ...:|.:|    |...|..|
  Rat   299 EVPEHLFYSQ---DITYLNLR--HNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPVLLCE-- 356

  Fly   329 VKVLHDL----YGRFDMAASTFKVQRIKFLGDCYYCVAG-LGEADPD---HARMAVSLGIS---- 381
            :..|.:|    .|..|:.:....:..::.|     |:.| :..|.||   :.:...|||||
  Rat   357 ISTLTELNLSCNGFHDLPSQIGNLLNLQTL-----CLDGNVLTALPDELGNLQQLTSLGISFNNF 416

  Fly   382 -----------------MIANIQEV-------RAHRALDIDMRIGVHSGTLLAGVIGQAKLQY-- 420
                             |..|..|:       |.:....:|:|:......::..:.|...:.:
  Rat   417 SQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVDLRMNHLKTVIIENLEGNKHITHMD 481

  Fly   421 --DIWGPDVDIA------------NRLEATGKPGY----VHVSGRTLSSLNVAEYTVFPG--TEV 465
              |....|:|::            |:|......|:    ::.:...|:::||  |.| |.  |.:
  Rat   482 LRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRNLYANWNKLTAVNV--YPV-PSLLTSL 543

  Fly   466 AQSDPILQKQP-------------MTTYLLTAAPSR----NSVRSVDAVHSYAEI---------- 503
            ..|..:|:..|             ::..|||..|.|    .|:|.:...|::..:
  Rat   544 ELSRNLLECIPDWACEAKKLEILDISYNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPL 608

  Fly   504 ---DINALGASRKSPILRPTLMSDELREEFKKMPVGGF-NIRSPCCRDNS 549
               |:.....||    |..||.|..|...:........ ::.|.|..:.|
  Rat   609 EVLDVQHNTLSR----LPDTLFSKALNLRYLNASANSLESLPSACAGEES 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	10/68 (15%)
		CYCc	249..459	CDD:214485	49/273 (18%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	48/264 (18%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761
		PH_PHLPP-like	185..279	CDD:270131	7/41 (17%)
		PLN00113	284..>762	CDD:215061	73/393 (19%)
		leucine-rich repeat	289..309	CDD:275380	2/25 (8%)
		leucine-rich repeat	310..336	CDD:275380	7/27 (26%)
		leucine-rich repeat	337..359	CDD:275380	5/23 (22%)
		leucine-rich repeat	360..382	CDD:275380	4/21 (19%)
		leucine-rich repeat	383..405	CDD:275380	6/26 (23%)
		leucine-rich repeat	406..428	CDD:275380	5/21 (24%)
		leucine-rich repeat	429..452	CDD:275380	4/22 (18%)
		leucine-rich repeat	453..476	CDD:275380	3/22 (14%)
		leucine-rich repeat	477..497	CDD:275380	3/19 (16%)
		leucine-rich repeat	498..517	CDD:275380	3/18 (17%)
		leucine-rich repeat	518..539	CDD:275380	6/23 (26%)
		leucine-rich repeat	540..562	CDD:275380	4/21 (19%)
		leucine-rich repeat	563..584	CDD:275380	5/20 (25%)
		leucine-rich repeat	586..607	CDD:275380	2/20 (10%)
		leucine-rich repeat	608..631	CDD:275380	7/26 (27%)
		leucine-rich repeat	632..681	CDD:275380	3/23 (13%)
		leucine-rich repeat	682..705	CDD:275380
		leucine-rich repeat	706..728	CDD:275380
		leucine-rich repeat	751..772	CDD:275380
		PP2Cc	820..1069	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900