DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and NPR3

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001191304.1	Gene:	NPR3 / 4883	HGNCID:	7945	Length:	541	Species:	Homo sapiens

Alignment Length:	293	Identity:	51/293 - (17%)
Similarity:	95/293 - (32%)	Gaps:	100/293 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 HPDVSILYADVV---------NYTHLTTTLTV-----EKLVKVL-HDLYGRFDMAASTFKVQRIK 352
            |.|:.:|.|..:         .|:|||.....     |.::.:. |..:.|..:..|..|::|
Human   149 HWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLER-- 211

  Fly   353 FLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRAL-------DIDMRIGVHSGTLLA 410
               :||:.:.|:.|.                  .||...|.::       |:|:.
Human   212 ---NCYFTLEGVHEV------------------FQEEGLHTSIYSFDETKDLDLE---------- 245

  Fly   411 GVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQ 475
                             ||...::|:.:...:..|..|:.|:.:                :..:.
Human   246 -----------------DIVRNIQASERVVIMCASSDTIRSIML----------------VAHRH 277

  Fly   476 PMTT--YLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGF 538
            .||:  |........||....|.  |:...|.:...|.:....|:...:...::.||:|.   ..
Human   278 GMTSGDYAFFNIELFNSSSYGDG--SWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKF---SM 337

  Fly   539 NIRSPCCRDNSN-DEKVNHGLGMFCVAFKDSSL 570
            .::|...:...| ::.||    ||...|.|:.|
Human   338 EVKSSVEKQGLNMEDYVN----MFVEGFHDAIL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831
		CYCc	249..459	CDD:214485	29/177 (16%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	32/204 (16%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
NPR3	NP_001191304.1	PBP1_NPR_C_like	54..446	CDD:107381	51/293 (17%)
		ANF_receptor	71..422	CDD:279440	51/293 (17%)
		TM_EphA1	476..507	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900