Protein Alignment ACXB and NPR2

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001365852.1
• Gene: NPR2 / 4882
• HGNCID: 7944
• Length: 1050
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 80/270 - (29%)
• Similarity: 141/270 - (52%)
• Gaps: 40/270 - (14%)

  Fly   223 IMNDTMVR-SSFLDRHQFLKEE---MWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETD 283
            |:::.::| ..:.:..:.|.||   .:|.:.|:.|: ||..|||..:|:.:::.  |.:.....|
Human   800 ILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEA-LLYQILPHSVAEQLKRG--ETVQAEAFD 861

  Fly   284 SDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKV 348
            |                     |:|.::|:|.:|.|:...|..::|.:|:|||..||.....|.|
Human   862 S---------------------VTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDV 905

  Fly   349 QRIKFLGDCYYCVAGL----GEAD-PDHARMAVSLGISMIANIQEVRAHRALD-IDMRIGVHSGT 407
            .:::.:||.|..|:||    |:.. |:.||||::| :..:::.: :| ||..| :.:|||||:|.
Human   906 YKVETIGDAYMVVSGLPGRNGQRHAPEIARMALAL-LDAVSSFR-IR-HRPHDQLRLRIGVHTGP 967

  Fly   408 LLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPIL 472
            :.|||:|....:|.::|..|:.|:|:|:.|:...:|||..|..:|:  |...|. .|:.....:.
Human   968 VCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALD--ELGCFQ-LELRGDVEMK 1029

  Fly   473 QKQPMTTYLL 482
            .|..|.||.|
Human  1030 GKGKMRTYWL 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	71/238 (30%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	63/191 (33%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371
NPR2	NP_001365852.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	521..795	CDD:270944
		HNOBA	<801..849	CDD:462234	13/48 (27%)
		CYCc	828..1012	CDD:214485	65/210 (31%)