DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and NPR2

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_024303324.1	Gene:	NPR2 / 4882	HGNCID:	7944	Length:	1103	Species:	Homo sapiens

Alignment Length:	270	Identity:	80/270 - (29%)
Similarity:	141/270 - (52%)	Gaps:	40/270 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 IMNDTMVR-SSFLDRHQFLKEE---MWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETD 283
            |:::.::| ..:.:..:.|.||   .:|.:.|:.|: ||..|||..:|:.:::.  |.:.....|
Human   853 ILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEA-LLYQILPHSVAEQLKRG--ETVQAEAFD 914

  Fly   284 SDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKV 348
            |                     |:|.::|:|.:|.|:...|..::|.:|:|||..||.....|.|
Human   915 S---------------------VTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDV 958

  Fly   349 QRIKFLGDCYYCVAGL----GEAD-PDHARMAVSLGISMIANIQEVRAHRALD-IDMRIGVHSGT 407
            .:::.:||.|..|:||    |:.. |:.||||::| :..:::.: :| ||..| :.:|||||:|.
Human   959 YKVETIGDAYMVVSGLPGRNGQRHAPEIARMALAL-LDAVSSFR-IR-HRPHDQLRLRIGVHTGP 1020

  Fly   408 LLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPIL 472
            :.|||:|....:|.::|..|:.|:|:|:.|:...:|||..|..:|:  |...|. .|:.....:.
Human  1021 VCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALD--ELGCFQ-LELRGDVEMK 1082

  Fly   473 QKQPMTTYLL 482
            .|..|.||.|
Human  1083 GKGKMRTYWL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	14/56 (25%)
		CYCc	249..459	CDD:214485	67/215 (31%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	63/191 (33%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556
		PK_GC-A_B	521..848	CDD:270944
		HNOBA	<857..902	CDD:311573	13/45 (29%)
		CYCc	881..1065	CDD:214485	65/210 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810