DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXB and Adcy1

DIOPT Version :9

Sequence 1:NP_620474.2 Gene:ACXB / 53427 FlyBaseID:FBgn0040509 Length:1114 Species:Drosophila melanogaster
Sequence 2:NP_033752.1 Gene:Adcy1 / 432530 MGIID:99677 Length:1118 Species:Mus musculus


Alignment Length:1147 Identity:294/1147 - (25%)
Similarity:471/1147 - (41%) Gaps:329/1147 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 AIVVLVAVPG-----------ILSINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFKY 140
            |:..|:..||           :..|.|...||:        :::.|..:..|..:.|:.:|.   
Mouse    75 ALAELLGAPGPAPGLAKGSHPVHCILFLALFVV--------TNVRSLQVSQLQQVGQLALFF--- 128

  Fly   141 HWPLNTLYDVFVLCMIYMFLPIPSIRGAA-------------LLATSV--------SLMYIGLFI 184
                 :|....:.|...:..|..|..|.|             ||.|.|        ||:.||..:
Mouse   129 -----SLTFALLCCPFALGGPARSSAGGAMGSTVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGL 188

  Fly   185 YFLKSDDEDISEVVHDL--------------DTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLD 235
            ....|         |.|              .|:..:...:.|.|:.|:|.||:.:...|.:||.
Mouse   189 VVAAS---------HLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTERSQRKAFLQ 244

  Fly   236 RHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSI---KERIMLSETDSDRIVVNARRTENF 297
            ....:::.:.|....:::..||.|:||..:|..:::..   .|||.                 :.
Mouse   245 ARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIF-----------------HK 292

  Fly   298 MAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVA 362
            :.||.|.:||||:||:|.:|.|.:..|.::|||:|::|:|:||..|:....:|||.||||||||:
Mouse   293 IYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVS 357

  Fly   363 GLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDV 427
            ||.:...|||...|.:|:.||..|..|.....:|::||:|:|:|.:|.||:|..|.|||:|..||
Mouse   358 GLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDV 422

  Fly   428 DIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVR 492
            .:||.:||.|.||.||::..||:.|| .:|.|.||          ......|:|.|         
Mouse   423 TLANVMEAAGLPGKVHITKTTLACLN-GDYEVEPG----------HGHERNTFLRT--------- 467

  Fly   493 SVDAVHSYAEIDINALGASRKSPILRPTLMSD---ELREEFK----------------KMPVGGF 538
                 |:   |:...:..|.:..|....::||   ..|.:||                |..:...
Mouse   468 -----HN---IETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFS 524

  Fly   539 NIRSPCCRDNSN-------DEKVNH-----------------------------------GLGMF 561
            |:.:  |.|:..       .||:.:                                   .|..|
Mouse   525 NVMT--CEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFF 587

  Fly   562 CVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCC--LIYIQIVNDKFTICVECIVIDMVVFTFLT 624
            .:.:|....|..|....|.....:|:||..:...  |||:.::.....:.:      ::||    
Mouse   588 TLKYKHVEREQKYHQLQDEYFTSAVVLALILAALFGLIYLLVIPQSVAVLL------LLVF---- 642

  Fly   625 SLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQ-----HSFVLRVTIYMSIVASYYLLI 684
            |:.|:                     |:|.|:....|:|     .:..:|..:.:.||...|.:.
Mouse   643 SICFL---------------------VACTLYLHITRVQCFPGCLTIQIRTALCVFIVVLIYSVA 686

  Fly   685 STILLNCDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDM--ISLIV----GVSYTFARIPF-AL 742
            ...::.|                         .||.::..  .||:|    |.......:|. :.
Mouse   687 QGCVVGC-------------------------LPWAWSSQSNSSLVVLAAGGRRTVLPALPCESA 726

  Fly   743 KMLITCCATVAYLVIVFFQYS----FIFEHSATTTPFMKAELAHCLRV------------CMMLL 791
            ...:.||......:.:|.:.|    .|.....||:..:..||:...:|            .|.:|
Mouse   727 HHALLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAIL 791

  Fly   792 ----TMYAKERQSEFNTKINFKINQDLQGKQKAAD-----ITNKSIIILLTNILPSHVVEVYL-D 846
                |:....||.:...::::.  ...|.:::..|     :.||.|   |.|:||:||.:.:| .
Mouse   792 LFSCTLALHARQVDVRLRLDYL--WAAQAEEERDDMERVKLDNKRI---LFNLLPAHVAQHFLMS 851

  Fly   847 SVANHELYYENYKMVSVMFAMLINF----------QMDLPSLRVLNDIITEFDRLLNAYKEYYV- 900
            :..|.:|||::|..|.||||.:.||          .|.:..||:||:||.:||.|::  |::|. 
Mouse   852 NPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMD--KDFYKD 914

  Fly   901 VEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFA 965
            :||||.:|.|||||.||..|.     |:|...|.||.|                    ..:..||
Mouse   915 LEKIKTIGSTYMAAVGLAPTA-----GTRAKKSISSHL--------------------CTLADFA 954

  Fly   966 LDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMEST 1030
            :|:..||...|.        ::.:...:.:||:.|.::|||:||.:|.||||||.||:||||:||
Mouse   955 IDMFDVLDEINY--------QSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDST 1011

  Fly  1031 GLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFV 1072
            |:.|.|.||:|...:|::.....:.||...|||:||:.|||:
Mouse  1012 GVQGRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGEMLTYFL 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXBNP_620474.2 AC_N <36..276 CDD:292831 46/237 (19%)
CYCc 249..459 CDD:214485 84/212 (40%)
Nucleotidyl_cyc_III 298..484 CDD:299850 80/185 (43%)
CYCc 825..1047 CDD:214485 88/233 (38%)
Nucleotidyl_cyc_III 853..1072 CDD:299850 87/229 (38%)
Adcy1NP_033752.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
AC_N <158..291 CDD:292831 31/158 (20%)
CYCc 257..452 CDD:214485 83/212 (39%)
Guanylate_cyc 293..475 CDD:278633 83/209 (40%)
Interaction with calmodulin. /evidence=ECO:0000250 492..519 3/26 (12%)
CYCc 825..1036 CDD:214485 89/248 (36%)
Guanylate_cyc 858..1055 CDD:278633 88/231 (38%)
Interaction with calmodulin. /evidence=ECO:0000250 1023..1046 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1079..1118
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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