Protein Alignment ACXB and Ac13E

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001259575.1
• Gene: Ac13E / 32485
• FlyBaseID: FBgn0022710
• Length: 1703
• Species: Drosophila melanogaster
• Alignment Length: 1655
• Identity: 310/1655 - (18%)
• Similarity: 546/1655 - (32%)
• Gaps: 704/1655 - (42%)

  Fly     6 AYAPR-KCYLDYTD--------------ERLWERGYLKAKCKELCLEEEYK-------KYQIRLM 48
            |.||. :.||..|.              ||...:.:|..|.....|||:|:       :.:.|..
  Fly    34 ALAPHIQTYLSQTGRRHSCCSVMLPVAFERAAAKSWLDPKFDSPVLEEQYQASVFPHVRMRYRFT 98

  Fly    49 ISYLTVFFPLFIFVVVGCEL--CPWIFSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVLR-H 110
            :||:.:           |.|  |.:...:.....::..:::...::::..|:::.|....:.| |
  Fly    99 LSYILL-----------CSLMWCLYFVVDGGSEDFWRPISSSFSMLSLVTIMALCFTHWDLYREH 152

  Fly   111 RWIMVFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLYDVFVLC-----MIYMFLPIPSIRGA-- 168
            |.:   :|.::|.::....: ..|.:..:...||..    |.:|     :||..||:|...||
  Fly   153 RTV---TSAVTALLLCGASL-AFLTYTGRAFSPLGH----FAICLEIVLLIYTALPMPLWLGAST 209

  Fly   169 ----ALLATSVSLMYIGLFIYF---------------LKSDDEDISEVVHDLDTICVDIFHYLGF 214
                ::....||.|.||.....               ::::.:..:.:      :.:.|..:|..
  Fly   210 AISYSIAFEMVSHMVIGCSAIHGGPMHGGGGAAGGSGMEANGDPSNRI------LILRIMAHLSV 268

  Fly   215 NLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIML 279
            :|:|:...|||...:|.:|:...|.|.....|...:|.:..::.|::||::|.         ::|
  Fly   269 HLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSVMPPKVAD---------MLL 324

  Fly   280 SE-----TDSDRIVVNAR----RTEN-----FMAIQIH--PDVSILYADVVNYTHLTTTLTVEKL 328
            :|     .|:..:...:.    |..|     |....:|  .:||||:||:|.:|.:::|.|.|:|
  Fly   325 NEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENVSILFADIVGFTRMSSTKTAEQL 389

  Fly   329 VKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHR 393
            |::|:||:.|||...|....::|..||||||||:|..|...|||...|.:|:.||..::...|.|
  Fly   390 VEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADHAICCVEMGLGMIDAMRCFDAQR 454

  Fly   394 ALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEY- 457
            ...:.||:|||:||:|.|::|..::::|:|..||.:||::|::|||..||:|..|.|.|..|.|
  Fly   455 HEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMESSGKPEQVHISQETSSFLGDAYYL 519

  Fly   458 ----------TVF---------------------------------------------------- 460
                      |.|
  Fly   520 EEGEEVFGHRTYFVVGRRRDFTRTNSLSPSMPANATGSSLLLPGAHGASLSQSATNVSAVQPNVP 584

  Fly   461 PGTEVAQ------SDPILQKQPMTTYL-------------------------------------- 481
            |.:.|.|      ..|:|..:|..|.|
  Fly   585 PASPVGQLSSSLNPSPVLSMRPRLTSLSMKMRKKSQSRDRDVERGIIHPAAAGIPPVIVVRERPK 649

  Fly   482 --LT---------------------------AAPSRNSV-------------------------- 491
              :|                           ||.:|:.:
  Fly   650 IIITTKSLPGSLDSDEQPPVSPPLLPPANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGS 714

  Fly   492 ---------------RSVDAVHSYAEID------------INALGAS-RKSPIL----------- 517
                           :..:.:|.:.:::            .|..|.. ::.|:|
  Fly   715 SSAGHLDKEREREREKEKEELHQHNQLNPEETLAFMDNQMQNGNGCGYQQLPVLVESNHRTQTLD 779

  Fly   518 ----RPTL----------------------------------MSDEL------------------ 526
                ||.|                                  |.|::
  Fly   780 IPAARPVLHHAATSTALASSVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDISPFG 844

  Fly   527 -----REEFKKMPVGGFN----------------------------------------------- 539
                 |.:..:...||.|
  Fly   845 RSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSPLPRPRASTLATGRPTPNSLEP 909

  Fly   540 ---IRSPCC-------------------------------------------------------- 545
               ..||||
  Fly   910 GPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYALNQTA 974

  Fly   546 ----------------------------------------------------------------- 545
                                                                             
  Fly   975 ISQHRVSGYFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQ 1039

  Fly   546 -----RDNSNDEK---VNHGLGMFCVAFKDSSLEWSYLHKP------------------------ 578
                 |||:..::   |...|..|.:.||...||..:..|.
  Fly  1040 LIRCVRDNARSQRSYLVKPPLRKFSLYFKSRQLERDFRSKAHRFGAENETEGPPTLATPRYNTYI 1104

  Fly   579 DFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWF---KKVCWWRC 640
            |..:..:|.|...:...|:....|:..|.:.|       .:|:..|.:...:.|   :::|..:.
  Fly  1105 DIFVGIAVYLCISVSLFLMTQNTVSPSFRLWV-------TLFSCFTGIQVFALFLFTRQMCRRQS 1162

  Fly   641 VENDSRKY--------------------GR---VSCKLFKIWERIQHSFVLRVTIYMSIVASYYL 682
            ..|.|.::                    ||   .|| ..:|:|.|...:...:.:.:.:.....|
  Fly  1163 GSNVSNRFRSKSTTSEDLERDERGAAPGGRPHFESC-ADRIFEAISSWYPWHICLAVLMAMPVLL 1226

  Fly   683 LISTILLNCDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLIT 747
            :|:..||      .:|:.:.:..|||..:        :|..::...     .|.::...::.::.
  Fly  1227 IIANFLL------LDLEQLEAFEYHYGFL--------IFVCIVHFC-----NFTQLNCWVRNVLA 1272

  Fly   748 CCATVAYLVIVFFQYSFIFEHSATTTP--------------FMKAELAHCLRVCMMLLTMYAKER 798
            ..|.:.::.|...|. .::.|:.:...              |....:...|.:.::|:.::...|
  Fly  1273 FLAALCFIGIAVSQL-MVYSHNRSDQQQDQEASNFIQEIKWFQDYHVEIYLDLLLILVLVWFLNR 1336

  Fly   799 QSEFNTKINF----KINQD---LQGKQKAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYE 856
            :.|...::.|    ..|||   :|..:..||       :||.||:|.||.| :|.:.|.   |.|
  Fly  1337 EFEIGYRLTFYGNAVANQDKVRVQNMKNQAD-------MLLHNIIPKHVAE-HLKNTAK---YSE 1390

  Fly   857 NYKMVSVMFAMLINF-QMDLPS-------LRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMA 913
            |:..::::||.::|| :|...|       |||||::|.:||.||:. .|:..|||||.:|.|:||
  Fly  1391 NHHNIAIIFASIVNFNEMYDESYLGGKEFLRVLNELIGDFDELLSR-PEFRAVEKIKTIGSTFMA 1454

  Fly   914 ACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKA 978
            |.|||                          ...:||.::|   ...:..|::.:..|:...||.
  Fly  1455 ASGLD--------------------------PSHRGTGDEH---IHTLMEFSIAMQEVVDAFNKD 1490

  Fly   979 YAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETA 1043
            ..  .|:..|.     ||::.|::.|||:|.|:.:|||||:.||:||||:|||||..|.|.::..
  Fly  1491 LL--EFNLILR-----IGMNIGDVTAGVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCL 1548

  Fly  1044 NILE---QFDIMCMYRGMTFVKGRGEIPTY 1070
            ..|.   :|:    .||..:|||:..:..:
  Fly  1549 PFLTNRYEFE----PRGSVYVKGKDHMEVF 1574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	113/409 (28%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	80/323 (25%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	75/229 (33%)
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	79/224 (35%)
		PHA03307	836..>1015	CDD:223039	8/178 (4%)
		Guanylate_cyc	1388..1575	CDD:425528	75/228 (33%)