DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and GUCY2D

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	300	Identity:	83/300 - (27%)
Similarity:	128/300 - (42%)	Gaps:	79/300 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   788 MMLLTMYA-------KERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL 845
            :.:|..|:       :||..|...:           |||    |::    |||.:||..|.|...
Human   821 LRMLEQYSSNLEDLIRERTEELELE-----------KQK----TDR----LLTQMLPPSVAEALK 866

  Fly   846 DSVANHELYYENYKMVSVMFAMLINF----QMDLP--SLRVLNDIITEFDRLLNAYKEYYVVEKI 904
            ........|:|   .|::.|:.::.|    .|..|  .:.:|||:.|.||.::.::..|    |:
Human   867 TGTPVEPEYFE---QVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVY----KV 924

  Fly   905 KVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLM 969
            :.:|..||.|.||     ..:.|.| ||:..:.:..               ::...:.||.:..|
Human   925 ETIGDAYMVASGL-----PQRNGQR-HAAEIANMSL---------------DILSAVGTFRMRHM 968

  Fly   970 RVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPG 1034
            ..:.|                 .|.||:.:|..:|||||.:.|.|.::|:.||.||||||||||.
Human   969 PEVPV-----------------RIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1016

  Fly  1035 HIHVTQETANILEQFD--IMCMYRGMTFVKGRGEIPTYFV 1072
            .|||...|..||...|  .....||.|.:||:|...|:::
Human  1017 RIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831
		CYCc	249..459	CDD:214485
		Nucleotidyl_cyc_III	298..484	CDD:299850
		CYCc	825..1047	CDD:214485	65/227 (29%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	67/226 (30%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594
		PK_GC-2D	536..811	CDD:270945
		HNOBA	<820..865	CDD:369471	16/62 (26%)
		CYCc	846..1036	CDD:214485	71/242 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900