Protein Alignment ACXB and GUCY2F

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001513.2
• Gene: GUCY2F / 2986
• HGNCID: 4691
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1049
• Identity: 217/1049 - (20%)
• Similarity: 362/1049 - (34%)
• Gaps: 380/1049 - (36%)

  Fly   242 EEMWLRQARQQESMLLDSILPPQIAKPI---QQSIKERIM-LSETDSDRIVVNARRTENFMAI-- 300
            |::|:..|.:..|.|....||..:....   .||:::.:. :.:.|..||::....:    |:
Human   195 EDIWVHTANRVASALRSHGLPVGVVLTTGQDSQSMRKALQRIHQADRIRIIIMCMHS----ALIG 255

  Fly   301 ---QIH------------------PDVSILYADVVNYTH-----------------LTTTLTVEK 327
               |:|                  |..::||:  :.|.|                 ...|:|||.
Human   256 GETQMHLLECAHDLKMTDGTYVFVPYDALLYS--LPYKHTPYRVLRNNPKLREAYDAVLTITVES 318

  Fly   328 LVKVLHDLYGRFDMAASTFKV-QRIKF----------LGDCYYCVAGLGEADPDHARM-AVSL-- 378
            ..|.   .|..|..||:..:: ::::|          ....|:....:..|..::.:. |.||
Human   319 QEKT---FYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQ 380

  Fly   379 ---------------------GIS----MIANIQEVRAHRALDIDM-----RIG----------- 402
                                 |||    :..|::|...|....:||     |.|
Human   381 HSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFPGGRP 445

  Fly   403 --------------VHSG-----------TLLAGVI---GQA--------KLQYDIWGP------ 425
                          .|.|           |||..::   |.|        |:|. |.||
Human   446 PRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQL-IKGPNRILLT 509

  Fly   426 --DVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTY---LLTAA 485
              ||...|          .|...:..|..:|:    |..|...||.    :.|..::   .||.|
Human   510 LEDVTFIN----------PHFGSKRGSRASVS----FQITSEVQSG----RSPRLSFSSGSLTPA 556

  Fly   486 PSRNS---VRSVDAV----HSYAEI-DINALGASRKSPILRPTLMSDELREEFKKMPVGGFNIRS 542
            ...||   :...|.|    .|..:. |:.:: .||.|.:..   |..:||.| ...|:.||...|
Human   557 TYENSNIAIYEGDWVWLKKFSLGDFGDLKSI-KSRASDVFE---MMKDLRHE-NINPLLGFFYDS 616

  Fly   543 PCCRDNSNDEKVNHGLGMFCVAFK---DSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVND 604
                            |||.:..:   ..|||       |.:....|.|.|
Human   617 ----------------GMFAIVTEFCSRGSLE-------DILTNQDVKLDW-------------- 644

  Fly   605 KFTICVECIVIDMVV-FTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVL 668
               :....:::|::. ..:|....|:                  :||:..:...:..|    |||
Human   645 ---MFKSSLLLDLIKGMKYLHHREFV------------------HGRLKSRNCVVDGR----FVL 684

  Fly   669 RVTIYMSIVASYYLLISTILLNCDKNQYE-----------------LDVINSKLYHYDIV----- 711
            :||.|     .:..::..:.|:.:::..|                 |......:|.:.|:
Human   685 KVTDY-----GFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVM 744

  Fly   712 ---TDNCFNPWVFTDMISLIVGVSYTFARI-------PFALKMLITCCATVAYLVIVFFQYSFIF 766
               |..|.......::|:.:......:..:       |..|:::..|.|..|.....|.:   ||
Human   745 VRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDE---IF 806

  Fly   767 EHSATTTPFMKAELAHCLRVCMMLLTMYA-------KERQSEFNTKINFKINQDLQGKQKAADIT 824
            ....|   |.|.:..:.:...:.:|..|:       :||..|...:           |||    |
Human   807 NQFKT---FNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIE-----------KQK----T 853

  Fly   825 NKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLINF----QMDLP--SLRVLND 883
            .|    |||.:||..|.|.......   :..|.:.:|::.|:.::.|    .|..|  .:.:|||
Human   854 EK----LLTQMLPPSVAESLKKGCT---VEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLND 911

  Fly   884 IITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESK 948
            :.|.||.::.::..|    |::.:|..||.|.||     ..:.||| ||:..:.:..
Human   912 LYTLFDAIIGSHDVY----KVETIGDAYMVASGL-----PKRNGSR-HAAEIANMSL-------- 958

  Fly   949 GTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPH 1013
                   ::...:.||.:..|..:.|                 .|.||:.:|.::|||||.:.|.
Human   959 -------DILSSVGTFKMRHMPEVPV-----------------RIRIGLHSGPVVAGVVGLTMPR 999

  Fly  1014 YDIWGNPVNMASRMESTGLPGHIHVTQETANIL----EQFDIMCMYRGMTFVKGRGEIPTYF-VG 1073
            |.::|:.||.||||||||||..|||:..|..||    |.:::  ..||.|.:||:|...|:: :|
Human  1000 YCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEV--ELRGRTELKGKGTEETFWLIG 1062

  Fly  1074 IDDNLKFLP 1082
            ....:|.||
Human  1063 KKGFMKPLP 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	62/352 (18%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	57/327 (17%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	67/229 (29%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	44/248 (18%)
		Protein Kinases, catalytic domain	545..815	CDD:473864	60/347 (17%)
		HNOBA	<824..869	CDD:462234	17/63 (27%)
		CYCc	848..1040	CDD:214485	72/255 (28%)