Protein Alignment ACXB and GUCY2C

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_004954.2
• Gene: GUCY2C / 2984
• HGNCID: 4688
• Length: 1073
• Species: Homo sapiens
• Alignment Length: 1115
• Identity: 223/1115 - (20%)
• Similarity: 381/1115 - (34%)
• Gaps: 441/1115 - (39%)

  Fly    72 IFSEQKKLIYYE-SLTA------IVVLVAVPG--ILSINFFES-------FVLRH-RWIMVFSSI 119
            :|::|    |:| ::||      ::||...||  :|:.:|..:       |.|.: ..|::|..:
Human   275 LFNDQ----YFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHM 335

  Fly   120 LSAYI--------VVLVDIFQILVFHFKYHWPLNTLYDVFVL--CMIYMFLPIPSIRGAALLA-- 172
            |..::        ......|:.|.|. .|..|: ||.|...:  .|:.::..:.:.:...||.
Human   336 LKIFLENGENITTPKFAHAFRNLTFE-GYDGPV-TLDDWGDVDSTMVLLYTSVDTKKYKVLLTYD 398

  Fly   173 TSVSLMY-IGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMG--IFFRIMNDTMVRSSFL 234
            |.|:..| :.:...|...:    |::.:|:......|.....|.|.|  :...::...|:|....
Human   399 THVNKTYPVDMSPTFTWKN----SKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRK 459

  Fly   235 DRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQ------SIK----------ERIMLSETD 283
            |..  |:::.|             |.:||:...|::.      |:|          :|:...:.|
Human   460 DYE--LRQKKW-------------SHIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYD 509

  Fly   284 SDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKV----LHDLYGRFDMAAS 344
            ..|:::...:         |.|        .|:|. ...:.:.||:::    |...||
Human   510 KKRVILKDLK---------HND--------GNFTE-KQKIELNKLLQIDYYNLTKFYG------- 549

  Fly   345 TFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLL 409
            |.|:..:.| |...||..|                     :::||       ::..|....||.:
Human   550 TVKLDTMIF-GVIEYCERG---------------------SLREV-------LNDTISYPDGTFM 585

  Fly   410 AGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVH-----VSGRTLSSLN--VAEYTVFPGTEVAQ 467
            .... :..:.|||            |.|. .|:|     |.|| |.|.|  |....|...|:...
Human   586 DWEF-KISVLYDI------------AKGM-SYLHSSKTEVHGR-LKSTNCVVDSRMVVKITDFGC 635

  Fly   468 SDPILQKQPMTTYLLTAAPS---RNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREE 529
            :..:..|:.:.|     ||.   :.::.....|:||        |...:..|||        :|.
Human   636 NSILPPKKDLWT-----APEHLRQANISQKGDVYSY--------GIIAQEIILR--------KET 679

  Fly   530 FKKMPVGGFNIRSPCCRDNSNDEKV-----NHGLGMFCVAFKDSSLEWSYLHKPDFILKYSVLLA 589
            |..:          .|||  .:||:     ::|:..|               :||
Human   680 FYTL----------SCRD--RNEKIFRVENSNGMKPF---------------RPD---------- 707

  Fly   590 WGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRK---YGRV 651
                   ::::...:|          ::.|:..:          |.||    |.|..|   :.::
Human   708 -------LFLETAEEK----------ELEVYLLV----------KNCW----EEDPEKRPDFKKI 741

  Fly   652 SCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCF 716
            ...|.||:.                           |.:..||:..:|.:..:|.
Human   742 ETTLAKIFG---------------------------LFHDQKNESYMDTLIRRLQ---------- 769

  Fly   717 NPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSFIFEHSA-TTTPFMKAEL 780
                                                        .||...||.. ..|...|||
Human   770 --------------------------------------------LYSRNLEHLVEERTQLYKAE- 789

  Fly   781 AHCLRVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYL 845
                           ::|..    ::||.                         :||..||:...
Human   790 ---------------RDRAD----RLNFM-------------------------LLPRLVVKSLK 810

  Fly   846 D-SVANHELYYENYKMVSVMFAMLINF------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEK 903
            : .....|||.|    |::.|:.::.|      ...:..:.:||||...||.::    :::.|.|
Human   811 EKGFVEPELYEE----VTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIV----DHHDVYK 867

  Fly   904 IKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDL 968
            ::.:|..||.|.||     ..:.|:| ||...:::..               |:...|.||.|:.
Human   868 VETIGDAYMVASGL-----PKRNGNR-HAIDIAKMAL---------------EILSFMGTFELEH 911

  Fly   969 MRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLP 1033
            :..|.:.                 |.||:.:|...|||||...|.|.::|:.||.||||||||||
Human   912 LPGLPIW-----------------IRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLP 959

  Fly  1034 GHIHVTQETANILEQFDIMCMY--RGMTFVKGRGEIPTYFV-GIDD---NLKFLPSNVKKNNMSK 1092
            ..|||:..|..||::.:...:|  ||.|::||||...||:: |:.|   ||...|:...:..:..
Human   960 LRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQA 1024

  Fly  1093 RFS--ILSSL 1100
            .||  |.:||
Human  1025 EFSDMIANSL 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	80/422 (19%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	39/196 (20%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	70/226 (31%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:380592	32/145 (22%)
		PK_GC-C	480..750	CDD:270946	75/427 (18%)
		CYCc	788..979	CDD:214485	70/281 (25%)