DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and GUCY1B1

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	XP_011530203.1	Gene:	GUCY1B1 / 2983	HGNCID:	4687	Length:	662	Species:	Homo sapiens

Alignment Length:	442	Identity:	104/442 - (23%)
Similarity:	179/442 - (40%)	Gaps:	128/442 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 LVDIFQILVFH--FKYHWPLNTLYDVFVLCMIYMFLPIPSIR-GAALLATSVSLMYI-GLFIYFL 187
            |:.:|.::..|  ..:|..|:.:..||||......|.:..:. ...|..|.:|.:.: |..||..
Human   250 LLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLP 314

  Fly   188 KSDD------------ED-------ISEV-VHDLDTICVDIFHYLGFNLMGIFFR---------- 222
            ::|.            :|       :|:: :||.....|         |:|..||
Human   315 EADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLV---------LLGEQFREEYKLTQELE 370

  Fly   223 IMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKER--IMLSETDS- 284
            |:.|.:              ::.|| |.:.|....|:..|.:|     |:.|.:  :||.|.||
Human   371 ILTDRL--------------QLTLR-ALEDEKKKTDTGCPARI-----QAFKVQTTLMLCEKDSR 415

  Fly   285 ------------------DRI--------VVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTL 323
                              :|:        |.|..|.:..:..:.:.:|:||::.:|.:....:..
Human   416 STKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKH 480

  Fly   324 T----VEKLVKVLHDLYGRFDMAASTFK---VQRIKFLGDCYYCVAGLGEADPDHARMAVSLGIS 381
            .    ..|:|.:|:|||.|||....:.|   |.:::.:||.|..|:||.|....|||....|.:.
Human   481 ASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALD 545

  Fly   382 MIANIQEVRAHRALD---IDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVH 443
            |:    |:.....:|   :.:.||:|:|.::.|||||...:|.::|..|::.:|.|.||:.|
Human   546 MM----EIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKG--- 603

  Fly   444 VSGRTLSSLNVAEYTVFPGTEVAQSDPIL------------QKQPMTTYLLT 483
                   .:||:|||.........|||..            :|:||..:.|:
Human   604 -------KINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLS 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	37/182 (20%)
		CYCc	249..459	CDD:214485	66/248 (27%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	58/208 (28%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:311572
		HNOBA	207..449	CDD:311573	45/227 (20%)
		Guanylate_cyc	455..648	CDD:306677	57/206 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810