DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	349	Identity:	85/349 - (24%)
Similarity:	146/349 - (41%)	Gaps:	95/349 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 LDR-HQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENF 297
            |:| ||.|:||      :::...||.||.|..:|:.:.|..:              |.||:.:
Human   476 LERTHQALEEE------KKKTVDLLYSIFPGDVAQQLWQGQQ--------------VQARKFD-- 518

  Fly   298 MAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVA 362
                   ||::|::|:|.:|.:....|..:::.:|::||.|||.......:.:::.:||.|...|
Human   519 -------DVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAA 576

  Fly   363 GLGEADPDHARMAVSLGISMI--------------------------ANIQEVRAHRALDID--- 398
            ||......||:....:.:.|:                          .:||.|......:.|
Human   577 GLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGT 641

  Fly   399 --MRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAE-YTVF 460
              ||||:|||::||||:|....:|.::|.:|.:|::.|:...|..::||..|...|...| :|..
Human   642 EKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFI 706

  Fly   461 PGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDE 525
            |.:.....|...::.|...|.|       .||:                 ..|.|  :|:|.|..
Human   707 PRSREELPDNFPKEIPGICYFL-------EVRT-----------------GPKPP--KPSLSSSR 745

  Fly   526 LREEFKKMPVGGFNIRSPCCRDNS 549
            :    ||:   .:||.:...|:.|
Human   746 I----KKV---SYNIGTMFLRETS 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	14/42 (33%)
		CYCc	249..459	CDD:214485	59/241 (24%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	55/217 (25%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002
		HNOBA	316..503	CDD:285003	12/32 (38%)
		CYCc	485..705	CDD:214485	61/248 (25%)
		Guanylate_cyc	514..729	CDD:278633	57/230 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810