Protein Alignment ACXB and Adcy10

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_766617.2
• Gene: Adcy10 / 271639
• MGIID: 2660854
• Length: 1614
• Species: Mus musculus
• Alignment Length: 777
• Identity: 143/777 - (18%)
• Similarity: 249/777 - (32%)
• Gaps: 295/777 - (37%)

  Fly   214 FNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIM 278
            ||....|.:.|       .|:|.:.....:.:||.|...||       .|::...:|:.:.| |:
Mouse   224 FNFDEFFTKCM-------GFMDYYPSGDHKNFLRLACMLES-------DPELELSLQKYVME-II 273

  Fly   279 LSETDSDRIVVNARRTENFMAIQIHPDVSILYADVV----------------NYTHLTTTLTV-- 325
            |.:.|.       ::...::: ::.| |:|::.:::                ...|:|:.|.|
Mouse   274 LKQIDD-------KQLRGYLS-ELRP-VTIVFVNLMFKEQDKVEVIGSAIQAACVHITSVLKVFR 329

  Fly   326 EKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGL-GEADPDHARMAVSLGISMIANIQEV 389
            .::.||.     .||...|             :.||.|. ||..||....|:...:.:.....:|
Mouse   330 GQINKVF-----MFDKGCS-------------FLCVFGFPGEKAPDEITHALESAVDIFDFCSQV 376

  Fly   390 RAHRALDIDMRIGVHSGTLLAGVIGQ-AKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLN 453
            ...|.:.    |||.||.:..|::|. .:.:|.:.|..|:||.|: ....||.|.....|....|
Mouse   377 HKIRTVS----IGVASGIVFCGIVGHTVRHEYTVIGQKVNIAARM-MMYYPGIVSCDSVTYDGSN 436

  Fly   454 VAEY-------TVFPGTEVAQSDPILQKQPMT-------TYLL----TAAPSRNSVRSVDAVHSY 500
            :..|       .|..|  ||...|:.|...:.       .||:    ...|....||.:|...|.
Mouse   437 LPAYFFKELPKKVMKG--VADPGPVYQCLGLNEKVMFGMAYLICNRYEGYPLLGRVREIDYFMST 499

  Fly   501 AEIDINALGASR-----------KSPIL------------------------------------- 517
            .: |......||           ||.:|
Mouse   500 MK-DFLMTNCSRVLMYEGLPGYGKSQVLMEIEYLASQHENHRAVAIALTKISFHQNFYTIQILMA 563

  Fly   518 -------------RPTLMSDELR----EEFKKMPVGGFNIRSPCCRDNSNDEKVN-----HGLGM 560
                         |.|.:.:.::    |:|..:....|:::.|..|:.|...|:.     ..|.|
Mouse   564 NVLGLDTCKHYKERQTNLQNRVKTLLDEKFHCLLNDIFHVQFPVSREMSRMSKIRKQKQLEALFM 628

  Fly   561 FCVA----------------FKDSSLEWSYLHK-----PDFILKYSVLLAWGIGCC--------- 595
            ..:|                |.|.: .|:::.|     |.||: .|:.....:.|.
Mouse   629 KILAQTVREERIIFIIDEAQFVDGT-SWAFIEKLIRSMPIFIV-MSLAPFSEVPCAAANAIMKNR 691

  Fly   596 -LIYI-------QIVNDKFTICVECIV--IDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGR 650
             ..||       |.:.||  :||:..|  |...:.::|                 ||.
Mouse   692 NTTYITLGTMQPQEIRDK--VCVDLSVSSIPRELDSYL-----------------VEG------- 730

  Fly   651 VSCKL----FKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYHYDI- 710
             ||.:    .::.:.:.|..||                   |....:.:.:.:|..:.::.:.:
Mouse   731 -SCGIPYYCEELLKNLDHHRVL-------------------LFQQAETEQKTNVTWNNMFKHSVR 775

  Fly   711 VTDNCFNPWVFT-------DMISLIVGVSYTFARIPFALK---------------MLITCCATVA 753
            .||:.   .:||       ::..|:.||.......|.:||               ||:.|.|.:
Mouse   776 PTDDM---QLFTSISEGQKEVCYLVSGVRLNNLSPPASLKEISLVQLDSMSLSHQMLVRCAAII- 836

  Fly   754 YLVIVFFQYSFIFEHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDLQ 815
                           ..|.|..:..|:..|..:.||:..:......:.||.   |:.::|||
Mouse   837 ---------------GLTFTTELLFEILPCWNMKMMIKALATLVESNVFNC---FRSSKDLQ 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	13/61 (21%)
		CYCc	249..459	CDD:214485	50/236 (21%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	49/223 (22%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
Adcy10	NP_766617.2	CHD	40..214	CDD:143636
		CHD	292..461	CDD:143636	45/193 (23%)
		COG3899	485..>959	CDD:226415	77/467 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900