Protein Alignment ACXB and Gucy1b2

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_001257640.1
• Gene: Gucy1b2 / 25206
• RGDID: 2770
• Length: 742
• Species: Rattus norvegicus
• Alignment Length: 599
• Identity: 137/599 - (22%)
• Similarity: 225/599 - (37%)
• Gaps: 172/599 - (28%)

  Fly    19 ERLWERGYLKAKCKELCLEEEYKKYQIRLMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIYYE 83
            ||||             :|||              ||...|.|.:|        |.|..::
  Rat   260 ERLW-------------VEEE--------------VFCDAFPFHIV--------FDEALRV---- 285

  Fly    84 SLTAIVVLVAVPGILSINFF--ESFVLRHRWIMVFSSILSAYI---VVLVDIFQILVFHFKYHWP 143
            ....:.:...|||||:..|.  |.|.:.|..:....|.:..:|   .||....:::....|.. |
  Rat   286 KQAGVNIQKYVPGILTQKFALDEYFSIIHPQVTFNISSICKFINSQFVLKTRKEMMPKARKSQ-P 349

  Fly   144 LNTLYDVFV-----LCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDL-- 201
            :..|....:     .|||:|.  .|.:|  :|.....|.|::           .||:.  ||.
  Rat   350 MLKLRGQMIWMESLRCMIFMC--SPKLR--SLQELEESKMHL-----------SDIAP--HDTTR 397

  Fly   202 DTICVDIFHYLGFNLMGIFFRIMND----TMVRSSFLDRHQFLKEEM-----WLRQARQQESMLL 257
            |.|                  ::|.    .|..|..|::.   |||:     .|...:::...||
  Rat   398 DLI------------------LLNQQRLAEMELSCQLEKK---KEELRVLSNHLAIEKKKTETLL 441

  Fly   258 DSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTT 322
            .::||..:|..:::..|......||                       .:||::|||.:|::...
  Rat   442 YAMLPEHVANQLKEGRKVAAGEFET-----------------------CTILFSDVVTFTNICAA 483

  Fly   323 LTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLGISMIANIQ 387
            ....::|.:|:.:|.:||...|...|.:::.:||.|..|.|:......||:...:..:.|..:.:
  Rat   484 CEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAK 548

  Fly   388 EV-RAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSS 451
            || .......|.:|:|:|:|.:||||:|....:|.::|..|:.|:|:|:.|.|..||:|.....:
  Rat   549 EVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRA 613

  Fly   452 LNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEI-----------DI 505
            |....:.:....|:    .:..|..||||.|        :::::|...  ||           ::
  Rat   614 LKNKGFEIVRRGEI----EVKGKGKMTTYFL--------IQNLNATED--EIMGRPSAPADGKEV 664

  Fly   506 NALGAS-RKSP-ILRPTLMSDELREEFKKMPVGGFN----IRSPCCRDNSNDEKVNHG------- 557
            ...|.. |||| :.|.|   |..::.:|..|....|    ..||....||.|...|..
  Rat   665 CTPGNQVRKSPAVPRNT---DHQQQVYKGDPADASNEVTLAGSPVAGRNSTDAVNNQPSPDETKT 726

  Fly   558 --------LGMFCV 563
                    |..|||
  Rat   727 SVVASGPVLSAFCV 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	55/260 (21%)
		CYCc	249..459	CDD:214485	53/210 (25%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	52/186 (28%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002
		HNOBA	267..453	CDD:285003	52/250 (21%)
		CYCc	432..622	CDD:214485	53/212 (25%)
		Guanylate_cyc	459..642	CDD:278633	54/217 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900