DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and Gucy2g

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1060	Identity:	214/1060 - (20%)
Similarity:	347/1060 - (32%)	Gaps:	403/1060 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 ISEVVHDLDTIC--VDIFHY------LGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQAR 250
            :|.|...:..||  .|..|.      ||.|.....|.::.  .:..||.  .:.|.|:...|..:
  Rat   242 MSSVARVIILICSSEDAKHILQAAEDLGLNSREFVFLLLQ--QLEDSFW--KEVLAEDKVTRFPK 302

  Fly   251 QQESMLL-----------DSILPPQIAK-----PIQQSIKERIMLSETDS---DRIVVNARRTEN 296
            ..||:.|           |.....|:.:     |.|.||.....:|...:   |.:::.|:..|.
  Rat   303 VYESVFLIAPSTYGGSAGDDDFRKQVYQRLRRPPFQSSISSEDQVSPYSAYLHDALLLYAQTVEE 367

  Fly   297 FMAIQIHPD-------VSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQR---- 350
            .|  :...|       :|.|.||.|....:|.        .||.|..|:..|..|.:.:|:
  Rat   368 MM--KAEKDFRDGRQLISTLRADQVTLQGITG--------PVLLDAQGKRHMDYSVYALQKSGNG 422

  Fly   351 IKFLGDCYY--------------CVAGLGEADPDH----------ARMAVSLGISMIANIQEVRA 391
            .:||...:|              ..:|...:.|::          .|.....|..|.|::..|
  Rat   423 SRFLPFLHYDSFQKVIRPWRDDLNASGPHGSHPEYKPDCGFHEDLCRTKPPTGAGMTASVTAV-- 485

  Fly   392 HRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAE 456
                       :.:.|||......|.....:|.....:.|.            .|.|...::...
  Rat   486 -----------IPTVTLLVVASAAAITGLMLWRLRGKVQNH------------PGDTWWQIHYDS 527

  Fly   457 YTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAV------------HS-----YAEID 504
            .|:.|     |..|..:..||         ||.:|.:...|            |.     ||.:.
  Rat   528 ITLLP-----QHKPSHRGTPM---------SRCNVSNASTVKISADCGSFAKTHQDEELFYAPVG 578

  Fly   505 INA--------LGASRKSPILRPTLMSD-----ELREEFKKMPVGGFNIRSP-------CCRDNS 549
            :..        :|...::.|.:||::.:     ||:.| ..:|..|.....|       ||:..|
  Rat   579 LYQGNHVALCYIGEEAEARIKKPTVLREVWLMCELKHE-NIVPFFGVCTEPPNICIVTQCCKKGS 642

  Fly   550 NDEKVNHGLGMFCVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIV 614
            ..:           ..::|.      |:.|:|.|.|
  Rat   643 LKD-----------VLRNSD------HEMDWIFKLS----------------------------- 661

  Fly   615 IDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGRV---SC--------KL--FKIWERIQHSF 666
               .|:..:..:||:.           .:..|.:|.:   :|        ||  |.:|| .:|..
  Rat   662 ---FVYDIVNGMLFLH-----------GSPLRSHGNLKPSNCLVDSHMQLKLAGFGLWE-FKHGS 711

  Fly   667 VLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCFNPWVFTDMISL---- 727
            ..|  ||                    ||...|  :|:||            |...:::.|
  Rat   712 TCR--IY--------------------NQEATD--HSELY------------WTAPELLRLRELP 740

  Fly   728 ----IVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSFIFEHSATTTPFMKAELA-----HC 783
                ..|..|:||   ..|:.||                     |.....||...|.|     .|
  Rat   741 WSGTPQGDVYSFA---ILLRDLI---------------------HQQAHGPFEDLEAAPEEIISC 781

  Fly   784 L--------------------RVCMMLLTMYA------------KERQSEFNTKINFKINQDLQG 816
            :                    |:..::...:|            |:...|.:.:....|...:.|
  Rat   782 IKDSRAPVPLRPSLLEDKGDERIVALVRACWAESPEQRPAFPSIKKTLREASPRGRVSILDSMMG 846

  Fly   817 K-----------------QKAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSVM 864
            |                 |..|:  .:.:..||:.:|||.|.|   ..:|...:..|:::.|::.
  Rat   847 KLEMYASHLEEVVEERTCQLVAE--KRKVEKLLSTMLPSFVGE---QLIAGKSVEPEHFESVTIF 906

  Fly   865 FAMLINF------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAK 923
            |:.::.|      ...|..:::|||:.:.||..:..:..|    |::.:|..||.|.||..
  Rat   907 FSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQTHDVY----KVETIGDAYMVASGLPI---- 963

  Fly   924 SKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRAL 988
                 |..|.::                   ||:|    |.:|.|:.|.:  |......|.:|.
  Rat   964 -----RNGAQHA-------------------DEIA----TMSLHLLSVTT--NFQIGHMPEERL- 997

  Fly   989 STGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETAN-ILEQFDIM 1052
               ::.||:.||.::|||||.:.|.|.::|:.|||||||||:.||..|||:|.||. :|......
  Rat   998 ---KLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTARALLVAGGYH 1059

  Fly  1053 CMYRGMTFVKGRGEIPTYFV 1072
            ...||...|||:||..|:::
  Rat  1060 LQKRGTISVKGKGEQTTFWL 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	24/105 (23%)
		CYCc	249..459	CDD:214485	46/263 (17%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	39/220 (18%)
		CYCc	825..1047	CDD:214485	67/228 (29%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	68/225 (30%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	46/210 (22%)
		ANF_receptor	66..417	CDD:279440	42/188 (22%)
		PK_GC	558..832	CDD:270894	61/395 (15%)
		CYCc	868..1058	CDD:214485	69/236 (29%)
		Guanylate_cyc	895..1081	CDD:278633	68/227 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810