Protein Alignment ACXB and Gucy1b2

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: XP_011243363.2
• Gene: Gucy1b2 / 239134
• MGIID: 2660873
• Length: 829
• Species: Mus musculus
• Alignment Length: 915
• Identity: 172/915 - (18%)
• Similarity: 296/915 - (32%)
• Gaps: 325/915 - (35%)

  Fly   269 IQQSIKERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLH 333
            :|..:.|:  ..|...:::..:|...:.||...::.|                |:|    ||::.
Mouse   122 LQSLVTEK--FGEETWEKLKASAEVQDVFMTYTVYDD----------------TIT----VKLIQ 164

  Fly   334 DLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPDHARMAVSLG---ISMIANIQEVRAHRAL 395
            :.....|::....    :|..|:.::....:...|    ||..:||   ...|.|:..:.::.||
Mouse   165 EACKALDVSMEAI----LKLFGEYFFKFCKMSGYD----RMLRTLGGNLTEFIENLDALHSYLAL 221

  Fly   396 DIDMRIGVHSGTLLAGVIGQAKLQY--------------------DIWGPDV-----DIANRLEA 435
            .. ..:...|..:..|..|..:|.|                    |.:..||     |:...:|.
Mouse   222 SY-QEMNAPSFRVEGGADGAMRLHYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVER 285

  Fly   436 TGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSY 500
            |||                .|:.||                     |....:|..:|........
Mouse   286 TGK----------------KEHVVF---------------------LVVQKARRQIRGAKVNRPR 313

  Fly   501 AEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAF 565
            ...:|.|...|.:..:||.       :|.:..:||                          |...
Mouse   314 DSENIQAKQESLQGTLLRK-------KERYLSIPV--------------------------CPGE 345

  Fly   566 KDSSLEWSYLHKPDFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFIS 630
            |..|.          :::.||||..|         .:.|.|.                      .
Mouse   346 KSHSA----------VVRASVLLGKG---------PLGDTFQ----------------------P 369

  Fly   631 WFKKVCWWRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQ 695
            .|.:..|   :|.:      |.|..|.                ..:|....|.:....:|..|
Mouse   370 VFPERLW---IEEE------VFCNAFP----------------FHVVFDEALRVKQAGVNIQK-- 407

  Fly   696 YELDVINSKL---YHYDIVTDNCFNPWVFTDMISLIVGVSYTF------ARIPFA---------- 741
            |...::..|.   .::.||     :|.|..::.|:...::..|      ..:|.|
Mouse   408 YVPGILTQKFGLDEYFSIV-----HPQVTFNISSICKFINSQFILKTRREMMPEAWKSQPTLKLR 467

  Fly   742 --------LKMLITCCA----TVAYLVIVFFQYSFIFEHSATTTPFMKAELAHCLRVCMMLLTMY 794
                    ||.::..|:    ::..|.......|.|..|..|..                 |.:.
Mouse   468 GQMIWMESLKCMVFMCSPKLRSLQELEESKMHLSDIAPHDTTRD-----------------LILL 515

  Fly   795 AKERQSEFNTKINF-KINQDLQGKQKAADITNKSIIILLTNILPSHVVEVYLD--SVANHELYYE 856
            .::|.:|....... |..::|:.......|..|....||..:||.||.....:  .||..|
Mouse   516 NQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEGKKVAAGE---- 576

  Fly   857 NYKMVSVMFAMLINFQ------MDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAAC 915
             ::..:::|:.::.|.      ..:..:.:||.:.::||||.|.:..|    |::.:|..||...
Mouse   577 -FETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTNIHDVY----KVETIGDAYMVVG 636

  Fly   916 GLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLS--VCNKA 978
            |:...:       .:||..                          :..|||. ||:.:  |.|..
Mouse   637 GVPVPV-------ESHAQR--------------------------VANFALG-MRISAKEVMNPV 667

  Fly   979 YAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETA 1043
             .|.|.       :|.:||.||.::|||||...|.|.::|:.||.||||||.|||..:|::....
Mouse   668 -TGEPI-------QIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAH 724

  Fly  1044 NILEQFDIMCMYRGMTFVKGRGEIPTYFV-----GIDDNLKFLPS--------NVKKNNMSKRFS 1095
            ..||......:.||...|||:|::.|||:     ..:..:...||        :..:|.:.|..:
Mouse   725 RALENKGFEIVTRGEIEVKGKGKMTTYFLIRNLNATEVEIMGRPSALADGKEASTPRNQVKKPRA 789

  Fly  1096 ILSSL 1100
            :||::
Mouse   790 VLSNM 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	36/210 (17%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	35/213 (16%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	61/226 (27%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:462233	31/184 (17%)
		HNOBA	380..566	CDD:462234	38/231 (16%)
		Guanylate_cyc	572..754	CDD:425528	65/232 (28%)