Protein Alignment ACXB and Adcy2

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_705762.2
• Gene: Adcy2 / 210044
• MGIID: 99676
• Length: 1095
• Species: Mus musculus
• Alignment Length: 1128
• Identity: 324/1128 - (28%)
• Similarity: 520/1128 - (46%)
• Gaps: 218/1128 - (19%)

  Fly    52 LTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVLRHRWIMVF 116
            |.:||.:||.|      |  |.|..|||:...||...:.|||: |.|              .|.|
Mouse    90 LAIFFAIFILV------C--IESVFKKLLRVFSLVIWICLVAM-GYL--------------FMCF 131

  Fly   117 SSILSAYIVVLVDIFQILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRG---AALLATSVSLM 178
            ...:||:       .|:..|             :|::.::|..||. ::|.   |::|.:|...:
Mouse   132 GGTVSAW-------DQVSFF-------------LFIIFVVYTMLPF-NMRDAIIASVLTSSSHTI 175

  Fly   179 YIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEE 243
            .:.:::.......|      |....|..::..::..||.|.:.:.:.:..::.::.|....:|..
Mouse   176 VLSVYLSATPGAKE------HLFWQILANVIIFICGNLAGAYHKHLMELALQQTYRDTCNCIKSR 234

  Fly   244 MWLR-QARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENF--MAIQIHPD 305
            :.|. :.||||.:|| |:||..||..::..|.:|:...:..      ....|.||  :.::.|.:
Mouse   235 IKLEFEKRQQERLLL-SLLPAHIAMEMKAEIIQRLQGPKAG------QMENTNNFHNLYVKRHTN 292

  Fly   306 VSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGEADPD 370
            |||||||:|.:|.|.:..:..:||.:|::|:|:||..|...:..|||.||||||||:||..:.|:
Mouse   293 VSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPN 357

  Fly   371 HARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEA 435
            ||:..|.:|:.|...|::||....:||:||:|||||.:|.||||..|.|||:|..||.:||.:||
Mouse   358 HAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEA 422

  Fly   436 TGKPGYVHVSGRTLSSLNVAEYTVFPGT-EVAQSDPILQKQPMTTYL------------------ 481
            .|.||.||:|..||..||.| |.|..|. |:  .||.|::..:.||.
Mouse   423 GGVPGRVHISSVTLEHLNGA-YKVEEGDGEI--RDPYLKQHLVKTYFVINPKGERRSPQHLFRPR 484

  Fly   482 --LTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPIL--RPTLMSDELREEFKKMPVGGFNIRS 542
              |..|..|.|||....:.|:        ||::....|  |.::.::..:.....:|:|..|.::
Mouse   485 HTLDGAKMRASVRMTRYLESW--------GAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQN 541

  Fly   543 PCCRDNSN----DEKVN-------------------HGLGMFCVAFKDSSLEWSYLHKPDFILKY 584
            ...|..|.    :|::|                   ..:....:.|.:.::|..|........||
Mouse   542 RTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLFFYNKNIEKEYRATALPAFKY 606

  Fly   585 SVLLAWGIGCCLIYIQIVNDKFTICVECIVI---DMVVFTF---LTSLLFISWFKKVCWWRCVEN 643
            .|..|     |||::.|      ..|:.:|:   .::.|:|   ..||:||.:   ||:...:..
Mouse   607 YVTCA-----CLIFLCI------FIVQILVLPKTSILGFSFGAAFLSLIFILF---VCFAGQLLQ 657

  Fly   644 DSRKYGRVSCKLFKI--------WERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDV 700
            .|:|.......|.|.        |.||..:.|....|....|.:.:.|         .|..|..:
Mouse   658 CSKKASASLLWLLKSSGIIANRPWPRISLTIVTTAIILTMAVFNMFFL---------SNSEETTL 713

  Fly   701 INSKLYHYDI-VTDN----------CFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAY 754
            ..:...:.:: |.||          .|.|:.....|..::..| .|.|:.:.|||||...|.|.|
Mouse   714 PTANASNANVSVPDNQTAILHARNLFFLPYFIYSCILGLISCS-VFLRVNYELKMLIMMVALVGY 777

  Fly   755 LVIVFFQYSFIFEHSATTTPFMKAELAHCLR------VCMMLLTMYAKERQSEFNTKINFKINQD 813
            .:|:...::.:.: :.:...|.:..:...|:      :.:..:|:....||||:..:::|.....
Mouse   778 NIILLHTHAHVLD-AYSQVLFQRPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNK 841

  Fly   814 LQGKQKAADITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSVMFAMLINF------ 871
            .:.:::..:.......:||.|:||:||.|.:| .|:.|.|||:::|..|.||||.:.:|
Mouse   842 FKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTE 906

  Fly   872 ----QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHA 932
                :..|..||:||:||.:||.||:..| :..|||||.:|.|||||.||      |...|:.||
Mouse   907 SDVNKEGLECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATGL------SAVPSQEHA 964

  Fly   933 SYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGI 997
                           :..|..:..:. .|..||..|:..|...||        .:.:..::.:||
Mouse   965 ---------------QEPERQYMHIG-TMVEFAYALVGKLDAINK--------HSFNDFKLRVGI 1005

  Fly   998 STGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVK 1062
            :.|.::|||:||.:|.||||||.||:||||:|||:...|.||:||:.||:.....|..||:..||
Mouse  1006 NHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVK 1070

  Fly  1063 GRGEIPTYFVGIDDNLKFLPSNV 1085
            |:|::.||||..:.:.....||:
Mouse  1071 GKGDLKTYFVNTEMSRSLSQSNL 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	54/227 (24%)
		CYCc	249..459	CDD:214485	94/211 (45%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	87/206 (42%)
		CYCc	825..1047	CDD:214485	88/232 (38%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	86/228 (38%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	53/224 (24%)
		CYCc	240..443	CDD:214485	93/210 (44%)
		Guanylate_cyc	285..469	CDD:278633	86/186 (46%)
		DUF1053	499..603	CDD:283888	15/111 (14%)
		CYCc	852..1060	CDD:214485	89/238 (37%)
		Guanylate_cyc	882..1081	CDD:278633	87/229 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5262
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.830