Protein Alignment ACXB and ADCY4

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_640340.2
• Gene: ADCY4 / 196883
• HGNCID: 235
• Length: 1077
• Species: Homo sapiens
• Alignment Length: 1159
• Identity: 313/1159 - (27%)
• Similarity: 513/1159 - (44%)
• Gaps: 259/1159 - (22%)

  Fly    56 FPLFIFVVVGCELC--------PWIFSEQKKLIYYESLTA-----IVVLVAVPGILSINFFESFV 107
            :|| :.:::|..||        .|....:        ||:     ..||.|:.|...:....|..
Human    27 YPL-LLLLLGIVLCALAALLAVAWASGRE--------LTSDPSFLTTVLCALGGFSLLLGLASRE 82

  Fly   108 LR-HRWIMVFSSILSAYIVVLVDIFQILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRGAAL- 170
            .| .||....|.::...::.|...| :........|. ...|.:||:...|..||: .:|.||:
Human    83 QRLQRWTRPLSGLVWVALLALGHAF-LFTGGVVSAWD-QVSYFLFVIFTAYAMLPL-GMRDAAVA 144

  Fly   171 -LATSVS-LMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSF 233
             ||:|:| |:.:||::    ....|....:  |..:..:...:|..|:.|::.:.:.:..:|::|
Human   145 GLASSLSHLLVLGLYL----GPQPDSRPAL--LPQLAANAVLFLCGNVAGVYHKALMERALRATF 203

  Fly   234 LDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFM 298
            .:....|.....|...::.:..||.||||..:|:.::..|..|:...:..      ....|.||.
Human   204 REALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGS------RPESTNNFH 262

  Fly   299 AIQI--HPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCV 361
            ::.:  |..||:||||:|.:|.|.:..:.::||.:|::|:|:||..|...:..|||.||||||||
Human   263 SLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCV 327

  Fly   362 AGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPD 426
            :||..:.||||...|.:|:.|...|:::||...:||:||:|||||::|.||||..|.|||:|..|
Human   328 SGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHD 392

  Fly   427 VDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYL---------- 481
            |.:||.:||.|.||.||::|.||:.|..|......|.|  ..||.|::....|||
Human   393 VTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGME--HRDPYLRELGEPTYLVIDPRAEEED 455

  Fly   482 --------------LTAAPSRNSVRSVD---AVHSYAEIDINALGASRKSPILRPTLMSDELREE 529
                          |...||....|.::   |...:|.:.......|..:|:...||.|...:..
Human   456 EKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWS 520

  Fly   530 FKKMPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFK--DSSLEWS----------YLHKPDFIL 582
            ..:.       |:|    ...|::::.|...|....:  :|..:|.          |..:.:...
Human   521 LDRS-------RTP----RGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEK 574

  Fly   583 KY--SVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVV------------FTFLTSLLFISWFK 633
            :|  |.:.|:.      |.:...  |.:.:...:|.|:|            .|||..||.:.
Human   575 EYRLSAIPAFK------YYEACT--FLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILF--- 628

  Fly   634 KVCW----WRCVENDSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKN 694
             ||:    .|||....        |:......:......|..:.:::..:..||:..:.:
Human   629 -VCFSEDLMRCVLKGP--------KMLHWLPALSGLVATRPGLRIALGTATILLVFAMAI----- 679

  Fly   695 QYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKML-----ITCCATVAY 754
                    :.|:.:...:| |  |:...::.|:|..:|:   .:|.:|.::     :.|| |:.:
Human   680 --------TSLFFFPTSSD-C--PFQAPNVSSMISNLSW---ELPGSLPLISVPYSMHCC-TLGF 729

  Fly   755 L-VIVFFQYSF----------------IFEHSATTTPFMKAELAHCLRVCMML------------ 790
            | ..:|...||                :|.||       .|.|:.||.|.:.|
Human   730 LSCSLFLHMSFELKLLLLLLWLAASCSLFLHS-------HAWLSECLIVRLYLGPLDSRPGVLKE 787

  Fly   791 -------------LTMYAKERQSEFNTKINF----KINQDLQGKQKAADITNKSIIILLTNILPS 838
                         .|:....||:|:..:::|    |:.|:.:..:...::|.    :||.|:||:
Human   788 PKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTR----LLLENVLPA 848

  Fly   839 HVVEVYL-DSVANHELYYENYKMVSVMFAMLINFQ----------MDLPSLRVLNDIITEFDRLL 892
            ||...:: .:..|.:||:::|:.|.|:||.:.:|:          ..|..||:||:||.:||.||
Human   849 HVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELL 913

  Fly   893 NAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESK-GTENDHDE 956
            :..| :..|||||.:|.|||||.||             :|:...:.:|...|..|. ||
Human   914 SKPK-FSGVEKIKTIGSTYMAATGL-------------NATSGQDAQQDAERSCSHLGT------ 958

  Fly   957 VAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPV 1021
                |..||:.|...|.|.||        .:.:...:.:|::.|.::|||:||.:|.||||||.|
Human   959 ----MVEFAVALGSKLDVINK--------HSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTV 1011

  Fly  1022 NMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFVGID 1075
            |:||||||||:.|.|.||:|||..|:.....|..||:..|||:|::.|||:..|
Human  1012 NVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTD 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	125/377 (33%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	85/211 (40%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	88/229 (38%)
ADCY4	NP_640340.2	AcyC	68..453	CDD:441717	131/401 (33%)
		Guanylate_cyc	264..418	CDD:425528	74/153 (48%)
		Adcy_cons_dom	479..584	CDD:461877	18/115 (16%)
		Guanylate_cyc	864..1063	CDD:425528	89/230 (39%)