DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and gcy-36

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_510557.3	Gene:	gcy-36 / 191657	WormBaseID:	WBGene00001556	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	349	Identity:	88/349 - (25%)
Similarity:	145/349 - (41%)	Gaps:	85/349 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 MLITCCATVAYLVIVFFQYSFIFEHSATTTPFMKAELAHCLRVCMML-------LTMYAKERQSE 801
            ||::....:.||...:          .|:.|.:   |.:.||:..|.       |.:..::|.|:
Worm   340 MLMSSGGHIMYLCSPY----------VTSIPEL---LQYGLRLTAMPIHDPTRDLILLNQQRLSD 391

  Fly   802 FNTKINFKI-NQDLQGKQKAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSVMF 865
            ....:..:. |:.|:...|..::.......||..:||..|.:.....::.....||.   .:|||
Worm   392 VEMNLQLEANNEQLENMAKDLEVEKGKTDALLREMLPPSVAQQLKQGLSVEAREYEE---ATVMF 453

  Fly   866 AMLINFQMDLP------SLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKS 924
            ..:..||..:|      .:.:||::.|:||||:...|.|    |::.||.:||:..|:...:
Worm   454 TDVPTFQQIVPLCTPKDIVHLLNELFTKFDRLIGIQKAY----KVETVGDSYMSVGGIPDLV--- 511

  Fly   925 KFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDL-MRVLSVCNKAYAGRPFDRAL 988
                                       :||.||   :...||.: |...:||: .....|.
Worm   512 ---------------------------DDHCEV---ICHLALGMVMEARTVCD-PITNTPL---- 541

  Fly   989 STGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILE-----Q 1048
               .|..||.:|.::||||||..|.|.::|:.||.:|||||....|.||.::......|     :
Worm   542 ---HIRAGIHSGPVVAGVVGAKMPRYCLFGDTVNTSSRMESHSPIGRIHCSENAKKCAESTGRFE 603

  Fly  1049 FDIMCMYRGMTFVKGRGEIPTYFV 1072
            |:    .||...:||:||:.|||:
Worm   604 FE----PRGRVQIKGKGEMNTYFL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831
		CYCc	249..459	CDD:214485
		Nucleotidyl_cyc_III	298..484	CDD:299850
		CYCc	825..1047	CDD:214485	61/228 (27%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	66/230 (29%)
gcy-36	NP_510557.3	HNOB	3..167	CDD:285002
		HNOBA	217..435	CDD:285003	21/107 (20%)
		CYCc	415..604	CDD:214485	62/236 (26%)
		Guanylate_cyc	441..624	CDD:278633	67/235 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810