DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and gcy-21

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001364740.1	Gene:	gcy-21 / 191651	WormBaseID:	WBGene00001546	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	1245	Identity:	229/1245 - (18%)
Similarity:	409/1245 - (32%)	Gaps:	456/1245 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 GAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDT---------------------------- 203
            |||.:.:::.:....|      :.|:|: ||.||||.
Worm    52 GAAYIPSAMEIAINRL------NADKDL-EVFHDLDVNYVDTSKTAGPRAARTAALNNGTIAALG 109

  Fly   204 ----------------------IC-VDIFHYLGFNLMGIFFRIMNDTMVRS--SFLDRHQFLK-- 241
                                  :| :|:....||:...:......:::.:|  .|||::|:.|
Worm   110 LMRDCYIQSTILNINSKIAVSDVCEMDLSSVKGFDQTSVLMNSQTNSLAKSVMYFLDKYQWKKVA 174

  Fly   242 ----EEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENFMAIQI 302
                ..:....|.:..|.|||::    .|..|...:..|:......:|::..:|.:...|:....
Worm   175 LVSPSTVLTAFATRVRSDLLDAL----TANKIDILVDSRLDPMSDITDKVKEDAEKARIFIICDW 235

  Fly   303 HPDVSIL----------------------YADV-VNYTHLTTTLTVEKLVKV------------- 331
            ..:.::|                      |... .||..|..:...::||.:
Worm   236 SSNANLLRNYLFKLGEMNKMQSGEYFVLGYISYDTNYQWLEASSGDQRLVHLGASDINDYNLTEN 300

  Fly   332 -LHDLYGRFDMAAS---------------------------------------TFKVQRIKFLGD 356
             ||::|....:.:.                                       |.:..|||.|.|
Worm   301 DLHEVYKNVVILSDGPPPAEPNSTWEDIKSQVLMKKPAKMCPPYCNTTVSEKITPRWDRIKLLFD 365

  Fly   357 CYYCVAGLGEADPDHARMA-------------VSLGISMIANIQE-VRAHRALDIDMRIGVH--- 404
               .:..|.:|..|...:.             :|..|..:..:.| :..:.|:...::|..|
Worm   366 ---SIQYLADATNDALNIGANIYQSDIFYEYLISRKIDSVTGVTEFIDGYGAIVGSIQIYYHFSS 427

  Fly   405 ----SGTLL-AGVIGQAKLQYDIW-------GPDVDIANRL------------EATGKPG----- 440
                |.:|. ...:.|:.|...:|       |..:|..|:.            |..|.|.
Worm   428 SSHNSYSLFPCARLAQSSLLNTVWSLTDYSEGLSIDFVNKSAPKDTPVCGFYGENCGPPANNTFI 492

  Fly   441 -YVHVSGRTLSSLNVAEYTVFPGTE-----------VAQSDPILQKQPMTTYLLTAAPSRNSVRS 493
             .:.|....|..|.:|...::....           :.::..||:|.       |...|:.|:||
Worm   493 IVISVGVAVLIGLAIAAAFLYKRYRYERRLHSLFFMIDRNQIILKKH-------TNLMSQQSLRS 550

  Fly   494 VDAVH------------SYAEID-------INAL------GASRKSPILRPTLMSDELREEFKKM 533
            :.::|            |:..|:       |||.      ..:|..|.                .
Worm   551 MASIHGSVVAASQTLRDSHFFIEDYNNASSINASSIFNTGSTARAGPF----------------G 599

  Fly   534 PVGGFNIRSPCCRDNSNDEKVNHGLGMF---CVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCC 595
            |:.||...:....|....:..:.|:|::   .||.|       .:::.|.....|:.|
Worm   600 PIPGFGGVTGASEDEKWHQIPDFGVGLYEGRTVALK-------RIYRSDVEFTRSIRL------- 650

  Fly   596 LIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISW-------FKKVCWWRCVENDSRK------ 647
                :|.  |....|...||:.|.....:..:|:.:       .|.:     ::||...
Worm   651 ----EIA--KLQESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDI-----LDNDDMPLDDVFR 704

  Fly   648 ---------------------YGRV---SCKLFKIWERIQHSFVLRV------------------ 670
                                 :||:   :|.:...|.....||.||.
Worm   705 SQMTKDIIAGLEYLHSSPIGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQEDDVQEGKD 769

  Fly   671 TIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYHYDIVTDNCF---NPWVFTDM-----ISL 727
            .::.|   ...|..||.|..|.    .|.|..|.:|...||....|   .||....|     :||
Worm   770 QLWTS---PELLRWSTGLSQCG----VLLVQKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVSL 827

  Fly   728 IVGVSYTFARIPFA--LKMLITCCATVAYLVIVFFQYSFIFEHSATTTPFMKAELAHCLRVCMML 790
            :...:.. .:.||.  :.:|......|...|:..:          |..|..:..| |.::..:..
Worm   828 VKREALA-GKKPFRPDMAVLKESPRIVQETVVAAW----------TEDPLNRPSL-HQIKRKLKP 880

  Fly   791 LTMYAK-----------ERQSEFNTKINFKINQDLQGKQKAADITNKSIIILLTNILPSHVVEVY 844
            ||:..|           |:.::...|...:.|::|:|::..::       .||..:||    ||.
Worm   881 LTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEGEKAKSE-------ALLKMMLP----EVV 934

  Fly   845 LDSV-ANHELYYENYKMVSVMFAMLINF-QMDLPS-----LRVLNDIITEFDRLLNAYKEYYVVE 902
            .||: ....:..|:::..:|.|:....| :|...|     ::.|||:.|.|||:::.:..|
Worm   935 ADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVFDRIIDQFDVY---- 995

  Fly   903 KIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALD 967
            |::.:...||.|.||...      ....||...:.|...|.:                    |::
Worm   996 KVETIADAYMVASGLPVP------NGNHHAGEIASLGLALLK--------------------AVE 1034

  Fly   968 LMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGL 1032
            ..::..:.|:....|            ||:::|..:|||||...|.|.::|:.||.||||||.|:
Worm  1035 SFKIRHLPNEKVRLR------------IGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGI 1087

  Fly  1033 PGHIHVTQETANILEQ---FDIMCMYRGMTFVKGRGEIPTYFVG-----------IDDNLKFLPS 1083
            |..|:.:.....||:|   ::|  ..||:..:||:|:..||||.           |.:.:||  :
Worm  1088 PLRINCSGTAKEILDQLGGYEI--EERGIVEMKGKGKQMTYFVRGENSDMRRERIIRERVKF--A 1148

  Fly  1084 NVKKNNMSKR 1093
            ::||..:.::
Worm  1149 SLKKAQIQEK 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	29/167 (17%)
		CYCc	249..459	CDD:214485	51/332 (15%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	43/319 (13%)
		CYCc	825..1047	CDD:214485	58/228 (25%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	60/227 (26%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:415822	53/377 (14%)
		PK_GC	612..881	CDD:270894	54/312 (17%)
		HNOBA	<890..938	CDD:400168	12/58 (21%)
		Guanylate_cyc	944..1130	CDD:306677	62/229 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900