Protein Alignment ACXB and gcy-14

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_506660.2
• Gene: gcy-14 / 191647
• WormBaseID: WBGene00001540
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 1179
• Identity: 229/1179 - (19%)
• Similarity: 392/1179 - (33%)
• Gaps: 462/1179 - (39%)

  Fly   120 LSAYIVVLVDIFQILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVSL------M 178
            |:||..|.|           :.|.|.|..|               |...:...|:|:|      |
 Worm   109 LAAYYNVPV-----------FQWGLTTAAD---------------IGNVSRYPTTVTLSLDTHSM 147

  Fly   179 YIG-------------LFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVR 230
            .:|             :|||....|:|..:.:..||:.:.::
 Worm   148 ALGVREVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEKMGIE----------------------- 189

  Fly   231 SSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKE-----RIMLSETDSDR---- 286
                      ..::.|....|.:::.||:         :|:::.|     ||:::...:.|
 Worm   190 ----------NSDVTLAYMVQIQTVTLDA---------LQKALTEVSKRGRIIIACFANGRGFKK 235

  Fly   287 -----IVVNARRTENFMAIQIHPDVSILYADVVN----YT------HLTTTLTVEKLVKVLHDLY 336
                 .|:....|:.:|.:...|.....|.|.:|    |:      :..|.||.|:    :.|.|
 Worm   236 AFVASTVLAGMSTDEYMYMFAEPQSRGFYVDEINGGEHYSWDDTDGNFVTGLTPEQ----IRDAY 296

  Fly   337 GRF-------------------------------------DMAASTFKVQRIKFLGDCYYCVAGL 364
            |:.                                     |.:.||:||. ..:.|..:......
 Worm   297 GKVLYICDNMGLPTTITPEFANFSSQLISRMTEQPFNCVQDCSNSTYKVP-ATYAGQLFDAFYAY 360

  Fly   365 GEA-------DPDHARMAVSLGISMIANIQEVRAHRALDIDMRI-GVHSGTL------------- 408
            |.|       ||..|.:...   |.:.:          ||.|.. ||..||:
 Worm   361 GVALNRSLTQDPTRANLKNG---SFVLS----------DIGMSFQGVGGGTVTLDDTGTRIVQVY 412

  Fly   409 -----------LAG--VIGQAKLQY--------DIWGPDVDIANRLEATGKP--GYVHVSGRTLS 450
                       ||.  ||..::::|        |:|.        :....:|  |:   ||....
 Worm   413 MFALNTSLLPYLAASLVINGSEVEYTPFYKSEADLWS--------VRPLARPICGF---SGLECP 466

  Fly   451 SLNVAEYTVF-------------------------PGTEVAQSD-----PILQKQPM-------- 477
            ...|.||.|:                         ...|:.:.|     |.::.|.:
 Worm   467 PDFVKEYLVYTIIAAVIVVLALLAGCAGLLYTMQMKRKEMERQDLLWQVPFIELQQVQSKSKAEA 531

  Fly   478 TTYLLTAAPSRNSVRSVDA-------VHSYAEIDINALGASRKSPILRPTLMSDELREEFKKMPV 535
            :.:...:.||.::..:|::       :..|.:.||  |.|.:...||:   ...|.:.||::|
 Worm   532 SMHSFASGPSTSTKITVESRSETINFIFYYYQQDI--LAAMKHDLILQ---FDAEQKAEFRQM-- 589

  Fly   536 GGFNIRSPCCRDNSNDEKVNHGLGMFCVAFKDSSLEWSYLHK---PDFILKYSVLLAWGIGCCLI 597
                       .|.:::.:|..:|: |:........|.:..:   .|.|.|.|:.:
 Worm   590 -----------RNFDNDNLNKFIGL-CLDGPQLFSLWRFCSRGSLSDVISKSSMQM--------- 633

  Fly   598 YIQIVNDKFTICVECIVIDMVVFTFL----TSLLFI--SWFKKVCWW----RCVENDSR------ 646
                  |.|           .:|:.:    ..||||  |:.|  |..    ||...|.|
 Worm   634 ------DSF-----------FMFSLIRDISNGLLFIHNSFLK--CHGHLTSRCCLIDDRWQIKIS 679

  Fly   647 KYGRVSCKLFK-------IW---ERIQHSFVLRV---TIYMSIVASYYLLISTIL-----LNCDK 693
            .||..|.:.|:       :|   |.:::....|:   .||     |:.::.|.||     .:.:.
 Worm   680 GYGLKSVRTFENPKKEDLLWTPPENLRNENEERLPEGDIY-----SFGIICSEILTRSSAFDLEN 739

  Fly   694 NQYELDVINSKLYHYDIVTDNCFNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIV 758
            .:.:.|||   :|.......|...|       ||..|.:   ..|..||..||..|.|
 Worm   740 RKEKPDVI---IYQVKKGGHNPMRP-------SLDTGET---VEINPALLHLIRDCWT------- 784

  Fly   759 FFQYSFIFEHSATTTPFMKAELAH-----------CLRVCMMLLTMYAKERQSEFNTKINFKINQ 812
                     ...:..|.::....|           .:.....:|..||...:.|.:.:     .:
 Worm   785 ---------ERPSERPSIEQVRGHLNGMRDGRKSNLMDHVFNMLETYASTLEEEVSDR-----TK 835

  Fly   813 DLQGKQKAADITNKSIIILLTNILPSHVVE-VYLDSVANHELYYENYKMVSVMFAMLINFQ---- 872
            :|..::|.:|       :||..:||..|.: :.|......    |.::.|::.|:.::.|.
 Worm   836 ELVEEKKKSD-------VLLYRMLPKMVADKLKLGQTVEP----ETFEQVTIFFSDVVQFTTLAG 889

  Fly   873 --MDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYS 935
              ..|..:.:|||:.|.||.::    |...|.|::.:|..|:...||            .|.:.:
 Worm   890 KCTPLQVVTLLNDLYTIFDGII----EQNDVYKVETIGDGYLCVSGL------------PHRNGN 938

  Fly   936 SELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTG 1000
            ..:..:  .:.|.|         |:.   :|:..||..:        |.:|.    .:.|||:.|
 Worm   939 EHIRHI--ARMSLG---------FLS---SLEFFRVQHL--------PSERI----NLRIGINCG 977

  Fly  1001 EIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQF--DIMCMYRGMTFVKG 1063
            .::|||||.:.|.|.::|:.||.||||||.|.||.||||.|...:|.|.  ......||...:||
 Worm   978 SVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTESRGEVIIKG 1042

  Fly  1064 RGEIPTYFV 1072
            :|.:.||::
 Worm  1043 KGVMETYWL 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	28/179 (16%)
		CYCc	249..459	CDD:214485	56/314 (18%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	51/314 (16%)
		CYCc	825..1047	CDD:214485	61/228 (27%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	64/226 (28%)
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347	65/399 (16%)
		ANF_receptor	43..418	CDD:279440	65/394 (16%)
		PKc_like	535..800	CDD:304357	67/345 (19%)
		HNOBA	<817..860	CDD:285003	12/54 (22%)
		CYCc	839..1031	CDD:214485	65/244 (27%)
		Guanylate_cyc	866..1053	CDD:278633	64/232 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900