DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and gcy-9

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_509897.3	Gene:	gcy-9 / 191645	WormBaseID:	WBGene00001536	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	1028	Identity:	194/1028 - (18%)
Similarity:	338/1028 - (32%)	Gaps:	392/1028 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 VRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIK----ERIMLSETDSDR--- 286
            :..|.:...:|:....||  |.|.:.      .|.:.|...:|.:|    ..|:::....|:
Worm   255 IHRSEIKNEEFVFVIPWL--AHQNDH------YPWEAANVDKQEVKLAFENTIIITAHGYDKKFF 311

  Fly   287 ------------IVVNARRTENFMAI---------------------QIHPDVSILYADVVNYTH 318
                        ::.|...|.::|::                     .:|.:.|::::.:.|...
Worm   312 DDFQMKFSAVTGVLANHYATLSYMSLYDALFLYGLALRDAFEDGGGYNVHMNGSLIWSRMTNRQF 376

  Fly   319 LTTT---LTVEKLVKVLHDLYGRFDMAASTFKV-----QRIKFLGDC-----------------Y 358
            :..|   |...|.::|  ..|..:.....|.|:     .:....|.|                 |
Worm   377 IGMTGQVLMNNKAIRV--PSYATYHAINGTLKIVVELEAKNNDRGQCEKNEEMCSEHVAHETIQY 439

  Fly   359 YCVAGLGEADPDHARMAVS----------LGISMIANIQEV----------RAHRAL-DIDMRIG 402
            |..:..|:..|...:...:          :|.|::|.|..|          :..|.| |:..||.
Worm   440 YWPSDSGKLPPAVPKCGFTGAECDYRPYFIGASLLAFILTVGPLSYFIYLKQKERLLYDMTWRIP 504

  Fly   403 VHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQ 467
            ..|..:|.   |::|.::       .:|::.:::|.     .||    |:|           ..|
Worm   505 RESIKMLE---GKSKSEH-------SLASKSQSSGS-----FSG----SMN-----------SKQ 539

  Fly   468 SDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREEFKK 532
            :..|..||.::..:..|......||::                         |....||| ..|:
Worm   540 NGLIAAKQAVSNGVKLAIKRYQQVRNI-------------------------TFPKSELR-LLKE 578

  Fly   533 MPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFKDSSLEWSYLHKPDFILKYSVLLAWGIGCCLI 597
            :.:        |..||.|.        .:.::|...:         :||:.: ||.:.|
Worm   579 LKI--------CENDNLNK--------FYGISFNQQN---------EFIVMW-VLCSRG------ 611

  Fly   598 YIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIWERI 662
                                    .|..:||              ||..|.||          ..
Worm   612 ------------------------SLEDILF--------------NDELKLGR----------NF 628

  Fly   663 QHSFVLRVTIYMSIVASYYLLISTILL--NC--DKN------QYELD-VINSKLYHYDIVTDNCF 716
            |.||...|...::.:.:..||...:|.  ||  |.|      .:..: ||..||.|      |..
Worm   629 QVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTVKLTNFATEAVIFEKLDH------NEL 687

  Fly   717 NPWVFTDMISL--IVGVSYTFAR------IPFALKMLITC--------CATVAYLVIVFFQYSFI 765
            .|::.||..|.  :...:..|||      .|..::.::|.        .|.:..|.:|.:|..|.
Worm   688 RPFINTDSESADDVSDPTKDFARKKYLQQAPEIIREIVTTKTIPEGSQSADIYALGMVLYQILFR 752

  Fly   766 FE--H----------------------------SATTTPFMKAELAHCLRVCMMLLTMYAKERQS 800
            .|  |                            |:.|......:|..|:..|.:.:    .|.:.
Worm   753 VEPFHERNKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNLQLLSCIEACWLEI----PEMRP 813

  Fly   801 EFNTKINFKINQDLQ--GKQKAAD----------------ITNKSIII---------LLTNILPS 838
            ... |:...:|.:|:  ||....|                :.:::.::         ||.::||.
Worm   814 PIK-KVRTMVNANLKSTGKGSLVDQMMKMMEEYTANLENMVRDRTALLEEAQKQADRLLNSMLPK 877

  Fly   839 HVVEVYLDSVANHELYYENYKMVSVMFAMLINF------QMDLPSLRVLNDIITEFDRLLNAYKE 897
            .:.|   |......:..:.|...:|:|:.:..|      ...|..:..|||:.:.||.::..:..
Worm   878 SIAE---DLKIGKPVLPQLYSCATVLFSDIRGFTRISSTSTPLQVVTFLNDMFSGFDAIIAKHDA 939

  Fly   898 YYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHD------E 956
            |    |::.:|..||...|:.                               |||.:.      :
Worm   940 Y----KVETIGDAYMIVSGVP-------------------------------TENGNSHAQNIAD 969

  Fly   957 VAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPV 1021
            ||..|..|         :||...|.||.:..:    :.||..:|.:.|||||.:.|.|.::|:.|
Worm   970 VALKMRAF---------ICNFKLAHRPEELMM----VRIGFHSGPVAAGVVGLAAPRYCLFGDTV 1021

  Fly  1022 NMASRMESTGLPGHIHVTQETANILEQF--DIMCMYRGMTFVKGRGEIPTYFV 1072
            |.||||||||:...|.:::...|:|..|  ....:.||...|||:||..||::
Worm  1022 NTASRMESTGVANKIQISEGAYNLLHCFFPQFQMVERGKIEVKGKGECLTYYL 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	10/50 (20%)
		CYCc	249..459	CDD:214485	47/295 (16%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	41/252 (16%)
		CYCc	825..1047	CDD:214485	57/242 (24%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	62/232 (27%)
gcy-9	NP_509897.3	Periplasmic_Binding_Protein_Type_1	66..416	CDD:299141	25/170 (15%)
		ANF_receptor	69..404	CDD:279440	23/158 (15%)
		PKc_like	550..820	CDD:304357	66/386 (17%)
		HNOBA	<837..883	CDD:285003	5/48 (10%)
		CYCc	862..1054	CDD:214485	59/242 (24%)
		Guanylate_cyc	889..1076	CDD:278633	62/234 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810