DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and gcy-6

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001294696.1	Gene:	gcy-6 / 191644	WormBaseID:	WBGene00001533	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	85/354 - (24%)
Similarity:	161/354 - (45%)	Gaps:	63/354 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 MIYMF------LPIPSIRGAALLATSVSLMYIGLFIYFLK-SDDEDISEVVHDLDTICVDIFHYL 212
            :|||.      .|.||:.....:..:.:|:::....:..: |:..||.:|...|.::..:    .
Worm   766 IIYMLKKGGLQSPRPSLEHDESIEINPALLHLVRDCWTERPSERPDIKQVASQLRSMNTN----R 826

  Fly   213 GFNLMGIFFRIMND--TMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKE 275
            ..|||...|.::..  :.:.....:|.:.|.||      :::..:||..:||.|:|        :
Worm   827 NDNLMDHVFNVLESYASTLEDEVAERMKELVEE------KKKSDVLLYRMLPRQVA--------D 877

  Fly   276 RIMLSETDSDRIVVNARRTENFMAIQIHPD----VSILYADVVNYTHLTTTLTVEKLVKVLHDLY 336
            ::.|.:|                   :.|:    |::.::|||::|.|....|..::|.:|:.||
Worm   878 KLKLGQT-------------------VEPETFDIVTLFFSDVVSFTTLAGKCTPLQVVNLLNGLY 923

  Fly   337 GRFDMAASTFKVQRIKFLGDCYYCVAGLGEAD-PDHARMAVSLGISMIANIQEVRAHR--ALDID 398
            ..||.......|.:::.:||.|:..:|:...: .:|.|...|:.|:.:.::.:.....  ...|.
Worm   924 TIFDGIIEQHDVYKVETIGDGYFVASGVPRRNGNEHTRNIASMSINFVKSLADFSIPHLPGEKIK 988

  Fly   399 MRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSL-NVAEYTVFPG 462
            :|:|.|.|:::|||:|....:|.::|..|:.|:|:|:..|||.:|:|......| .:..:|..|.
Worm   989 IRVGFHCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNSKPGQIHLSEEANQMLMRLGGFTTEPR 1053

  Fly   463 TEVAQSDPILQKQPMTTYLL-----TAAP 486
            .||.    |..|..|.||.|     :|||
Worm  1054 GEVI----IKGKGVMATYWLLKMDESAAP 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	26/129 (20%)
		CYCc	249..459	CDD:214485	52/217 (24%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	54/198 (27%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
gcy-6	NP_001294696.1	PBP1_NPR_GC_like	29..445	CDD:107347
		ANF_receptor	57..424	CDD:279440
		PKc_like	585..822	CDD:304357	12/55 (22%)
		HNOBA	<847..879	CDD:285003	10/45 (22%)
		CYCc	858..1048	CDD:214485	54/222 (24%)
		Guanylate_cyc	885..1070	CDD:278633	53/188 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910