DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and gcy-5

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_496219.1	Gene:	gcy-5 / 191643	WormBaseID:	WBGene00001532	Length:	1122	Species:	Caenorhabditis elegans

Alignment Length:	336	Identity:	81/336 - (24%)
Similarity:	152/336 - (45%)	Gaps:	71/336 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 NLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIML 279
            |||...|.::.: ...:..:|..:..||   |...:::..:||..:||.|:|        ||:..
Worm   823 NLMDHVFNMLEE-YTSTLEVDIEERTKE---LTLEKKKADILLSRMLPKQVA--------ERLKA 875

  Fly   280 SETDSDRIVVNARRTENFMAIQIHPD----VSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFD 340
            .:|                   :.|:    |::|::|||.:|.|....:..::|.:|:|||..||
Worm   876 GQT-------------------VEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFD 921

  Fly   341 MAASTFKVQRIKFLGDCYYCVAGL----GEADPDHARMAVSLGISMIANIQEVRA-HRALD-IDM 399
            .......|.:::.:||.|.||:||    |.|   |.:..|.:.:..:...:..:. |...: :::
Worm   922 TIIEEHGVYKVESIGDGYLCVSGLPTKNGYA---HIKQIVDMSLKFMDYCKSFKVPHLPREKVEL 983

  Fly   400 RIGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEY-----TV 459
            |||::||..:|||:|.:..:|.::|..|:.|:|:|:.|||..:|:| ....||....|     |.
Worm   984 RIGINSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMS-EAAHSLLTDHYPHQYETS 1047

  Fly   460 FPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSD 524
            ..|..:.:...:::    |.::|....|                |..:| ::|.:|.:.......
Worm  1048 SRGEVIIKGKGVME----TFWVLGKTDS----------------DTKSL-STRTTPPITDENWPP 1091

  Fly   525 ELREEFKKMPV 535
            :::|:.||..|
Worm  1092 QMKEDLKKRAV 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	14/60 (23%)
		CYCc	249..459	CDD:214485	60/224 (27%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	55/200 (28%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347
		ANF_receptor	49..426	CDD:279440
		PK_GC	546..816	CDD:270894
		HNOBA	<830..873	CDD:285003	11/54 (20%)
		CYCc	852..1042	CDD:214485	60/220 (27%)
		Guanylate_cyc	879..1067	CDD:278633	54/195 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900