DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXB and phlp-2

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	201	Identity:	44/201 - (21%)
Similarity:	80/201 - (39%)	Gaps:	52/201 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 CVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKL------ 418
            |...|||   :..|:..|:   ||..:.|.|    |:|     ..:||:.|.:....||
Worm   823 CHCELGE---EGERLGASV---MIIRVHEKR----LEI-----ASTGTMSAAIARNQKLKMIING 872

  Fly   419 QYDIWGPDVDIANRLEATGKPGYV----HVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTT 479
            :|:|   |.|..:|:...  .|:|    .::|...||..:..::.||......|...:|......
Worm   873 RYEI---DDDEYSRIREA--HGFVDEENRINGVIGSSRQIGHFSTFPVVLPTHSYRNIQLNEQIE 932

  Fly   480 YLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGFNIRSPC 544
            .|:.......::.|:|        |:|:...:.:|||    :::.:::::.:....||
Worm   933 GLIVGNNMIWNMLSID--------DLNSTFHNNRSPI----VVAKKIQDQLQSYDYGG------- 978

  Fly   545 CRDNSN 550
               |||
Worm   979 ---NSN 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831
		CYCc	249..459	CDD:214485	27/108 (25%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	32/133 (24%)
		CYCc	825..1047	CDD:214485
		Nucleotidyl_cyc_III	853..1072	CDD:299850
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380
		leucine-rich repeat	254..288	CDD:275380
		PLN00113	283..>718	CDD:331614
		leucine-rich repeat	289..311	CDD:275380
		leucine-rich repeat	312..334	CDD:275380
		leucine-rich repeat	335..357	CDD:275380
		leucine-rich repeat	358..379	CDD:275380
		leucine-rich repeat	380..440	CDD:275380
		leucine-rich repeat	441..485	CDD:275380
		leucine-rich repeat	486..508	CDD:275380
		leucine-rich repeat	509..534	CDD:275380
		leucine-rich repeat	554..577	CDD:275380
		leucine-rich repeat	578..602	CDD:275380
		leucine-rich repeat	603..625	CDD:275380
		leucine-rich repeat	626..649	CDD:275380
		leucine-rich repeat	650..672	CDD:275380
		leucine-rich repeat	673..694	CDD:275380
		PP2Cc	754..985	CDD:214625	44/201 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900