Protein Alignment ACXB and acy-4

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_504486.4
• Gene: acy-4 / 178949
• WormBaseID: WBGene00000071
• Length: 1013
• Species: Caenorhabditis elegans
• Alignment Length: 1088
• Identity: 272/1088 - (25%)
• Similarity: 490/1088 - (45%)
• Gaps: 240/1088 - (22%)

  Fly    46 RLMISY---LTVFFPLFIFVVVGCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSINFFESFV 107
            |:..|:   |::......|...|.|   |:    |.||       :.:|..|..|||  ||.:
 Worm    93 RIQFSFVILLSICISEAAFSAFGAE---WL----KSLI-------LCILTLVISILS--FFHA-- 139

  Fly   108 LRHRWIMVFSSILSAYIV-----VLVDIFQILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRG 167
             :...::..:||:|..|:     :...:..:|:|                  ..|..||:..:
 Worm   140 -KRTELVCIASIISCVIISACTSMRTSVTYLLIF------------------STYSLLPMSFM-- 183

  Fly   168 AALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSS 232
             .::.::.:|.::..||..|.  |.::.     .|.|...:...:..|::|.......:.:.|.:
 Worm   184 -LMIFSTFALTFLVAFIGVLM--DYNVG-----FDIILTRVMMVILVNVVGSLVYYPTEFVQRKT 240

  Fly   233 FLDRHQFLKEEMWL-RQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTEN 296
            |.:..:.::..|.| ::..:||.:|| ::||..||..:::.      :.||..:|:
 Worm   241 FHETRKCVQSRMLLDKEMHRQEKILL-AVLPKNIAFEVKKD------MQETHEERM--------- 289

  Fly   297 FMAIQI--HPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYY 359
            |..|.|  :.|:|||:||:..:|:|.:....:.||.:|::|:.|||..||..:..|||.||||||
 Worm   290 FHKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKILGDCYY 354

  Fly   360 CVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWG 424
            ||.|:.|...:||...|.:|..||..|:.||....::::||:|:|:|....||:|..|.|:|:|.
 Worm   355 CVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWS 419

  Fly   425 PDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRN 489
            .||.:||::|:.|..|.||::..|.|.|..| |.:..|...::| ..|:|:.:.|:|:
 Worm   420 NDVTLANQMESGGLAGRVHITDATRSYLKGA-YILEEGNGGSRS-KFLEKEKIKTWLV------- 475

  Fly   490 SVRSVDAVHSYAEIDINALGASRKSPILRPTLMSDELREEFKKMPVGGFNIRSPCCRDNSNDEKV 554
                ||....|.    |....:...|::.|...:..:.:: :::.......|....|:..::|:|
 Worm   476 ----VDRSPDYD----NICQEATNHPVMVPWKSTRGISKQ-ERLTGMSTRTRGASTRNGLSEEEV 531

  Fly   555 NHGLGMFCVAFKDSSL----------EWSYLHKPDFILKYSVL-------------LAWGIGCCL 596
                   .|...||.|          .|..:|..::.|||..:             :.:.:   .
 Worm   532 -------LVENVDSHLRQGIQAIHQENWKTMHCKNWSLKYKQVRVENKFVRLKYKDIPFQV---T 586

  Fly   597 IYIQIVNDKFTIC--VECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSRKYGRVSCKLFKIW 659
            :|:.||    .||  ::..::::|.|:|:..:..:                    ..|..:|.:.
 Worm   587 LYVAIV----AICIGIKFGLMNLVSFSFVPQMFIV--------------------LTSVMIFILT 627

  Fly   660 ER-IQHSFVLRVTIYMSIVASYYLLIS---TILLNCDKNQYELDVINSKLYHYDIVTDNCF--NP 718
            .. |:|:.::.:     ::...::|:|   .||:...::::..||            :.||  |.
 Worm   628 RALIKHARLVSL-----VIGVLFILLSIQIVILMGMYESKFTCDV------------EKCFKNNY 675

  Fly   719 WVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSFIFEHSATTTPFMKAELAHC 783
            ..|.::..:....:.....:.|..|:|::.....::.|::..:...|.::.|..:.:..    .|
 Worm   676 TDFFEIFEICTLATCVILSVDFMTKLLMSMIYFSSFTVLITAKLIRINQYEALLSTYAN----FC 736

  Fly   784 LRVCMMLLTMYAKERQSEFNTKINF-----KINQDLQGKQKAADITNKSIIILLTNILPSHVVEV 843
            :..|:.||.:....|:||..::.:|     .:::.||.|:|...  |:|:   |.|||||||.:.
 Worm   737 VLSCLTLLLVVFSTRRSELISRYDFIWKLQALDEQLQMKRKHEQ--NRSV---LENILPSHVAKH 796

  Fly   844 YL-DSVANHELYYENYKMVSVMFAMLINFQM----------DLPSLRVLNDIITEFDRLLNAY-- 895
            :: |:.:..:||:|:.....:|||.|..|..          .:..||:||:||::||::|:..
 Worm   797 FVEDATSVSKLYHESRDNACIMFATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILD 861

  Fly   896 -KEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAF 959
             :|:..:||||.:..|||.|.|    ||..:.|                       :|.|.|.
 Worm   862 REEFKKIEKIKTISTTYMVASG----LAGRECG-----------------------DNSHVEA-- 897

  Fly   960 IMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMA 1024
             :..||.:|:..|...|        ..:.:...:.|||:.|.::|||:|:.:||||||||.||:|
 Worm   898 -IALFARELLVKLESTN--------IHSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVA 953

  Fly  1025 SRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTYFV 1072
            |||:|.|:.|.|.||:|..:|||........||...|||:|.:.|:|:
 Worm   954 SRMDSGGVAGRIQVTEEVKSILEPLGYNFECRGQINVKGKGMMETFFL 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	105/374 (28%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	73/187 (39%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	77/231 (33%)
acy-4	NP_504486.4	AcyC	93..455	CDD:441717	118/425 (28%)
		Guanylate_cyc	293..448	CDD:425528	64/154 (42%)
		Guanylate_cyc	807..1003	CDD:425528	78/233 (33%)