Protein Alignment ACXB and acy-3

DIOPT Version :10

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_497765.4
• Gene: acy-3 / 175489
• WormBaseID: WBGene00000070
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1096
• Identity: 217/1096 - (19%)
• Similarity: 407/1096 - (37%)
• Gaps: 260/1096 - (23%)

  Fly    81 YYESLTAIVVLVAVPGILSINFFESFVLRHRWIMVFSSILSAYIVVLVDIFQILVFHFKYHWPLN 145
            :|...||:::|::...|:      ..:||...|..|.  :.|.||:|:|:...|.   .|.....
 Worm    46 FYALWTAVILLLSTVTII------FHILRPARIAAFQ--ILAGIVLLLDVAFALP---GYESLFP 99

  Fly   146 TLYDVFVLCMIYMFLPIPSIRGAALLATS--VSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDI 208
            .|..||.|   |.|..:|..   |:||||  :|::....|:.|:        |.:|..:.:.:.:
 Worm   100 ALLAVFSL---YTFFSLPFY---AILATSTLISIVQTCSFLLFV--------EPLHTNELLAIIV 150

  Fly   209 FHYLGFNLMGIFFRIMNDTMVRSSFLDRHQFLKEEMWLRQARQQESMLLDSILPPQIAKPIQQSI 273
            .| :..|..||:.....|.:.|::||......:.|........:.:.||.|.||..:....:..|
 Worm   151 VH-IWTNFTGIYLCSTADRLARNAFLSARNSSEAESTAEFQSNRLNKLLSSFLPYHLINQARHQI 214

  Fly   274 K--ERIMLSETDSDRIVVNARRTENFMAIQIHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLY 336
            .  :..:.:||                    :..||:.|..:|.:..:....:.....:||.:|.
 Worm   215 TLYKPHLYNET--------------------YSQVSVAYGRLVGFESVLAQCSSIDAARVLKELD 259

  Fly   337 GRFDMAASTFKVQRIKFLGDCYYC-VAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMR 400
            .|.:..|::....|:...|....| :.|:   |..||.......:.:...|...|.....|:.:.
 Worm   260 SRIERLAASNGCTRVASEGITAVCSIPGI---DSQHATKLCRFSMELETLINSFRDATGADVSVC 321

  Fly   401 IGVHSGTLLAGVIGQAKLQYDIWGPDVDIANRLEATG-KPGYVHVSGRT---LSSLNVAEYTVFP 461
            ||:.||.:.|||:|.:|..||:.|...|.|..:::.. :|| |:||..|   |.|....|....|
 Worm   322 IGIDSGPVTAGVVGVSKWHYDVIGSVFDNALLMQSNATEPG-VYVSNETRRFLGSTGEFELEKCP 385

  Fly   462 -GTEVAQSDPILQKQPMTT--YLLTAAPSRNSV-RSVDAVHSYAEIDINALGASRKSPILRPTLM 522
             |.::....|..:..|:..  .|:|...:.|.| :|:.|::.    .:..:|.::|.       .
 Worm   386 IGWKLYGHLPSPELFPVNKRFSLVTVPQAVNRVLQSIVAMNP----TLKTMGTNKKR-------K 439

  Fly   523 SDELREEFKKMPVGGFNIRSPCCRDNSNDEKVNHG--LGMFCVAFKDSSLEWSYLHK-------P 578
            .::.:|:|                 :...:||.|.  :......|::..||..| ||       |
 Worm   440 GEKSQEKF-----------------DMQKKKVEHSTIISTLSQRFRNPGLEAEY-HKETDHWFIP 486

  Fly   579 DFILKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVEN 643
            ...:....|:.:|     ||..:|..:....:..||..:.|..|:..:|:|.:|
 Worm   487 SLAISIFFLVVYG-----IYHMLVMPRLITSLALIVGALTVMFFILLMLYIDYF----------- 535

  Fly   644 DSRKYGRVSCKLFKIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKNQYELDVINSKLYHY 708
                                |:|...:|...:..|...:||..||..|       .::|:.....
 Worm   536 --------------------HTFSQFITRTSAGHAVSIILIIVILFVC-------GIVNTFSCPQ 573

  Fly   709 DIVTDNC---------FNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSF 764
            ....|.|         |..|..|..:         |.|.|.....::...:.:.|.:.::
 Worm   574 PNAPDVCQKAHFSTYSFAMWTITTAV---------FVRFPSVYLAILLIISLLTYGLQIY----- 624

  Fly   765 IFEHSATTTP-------FMKAELAHCLRVCMMLLTMYAKERQSEFNTKINF----KINQDLQGKQ 818
                  .|.|       ||......|..:.::.: ::...|:.|...:::|    |..::...|.
 Worm   625 ------VTRPDEFGPREFMTELDLSCFLISLVSM-VFLHSRRCERLLRLDFLAVVKGIEETSMKD 682

  Fly   819 KAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSVMFAMLINFQMD-LPSLRVLN 882
            |..::.|:    :|.|::|:||....:....  ::::.:::.|.:.:..:..|.:: ...:..||
 Worm   683 KLINLNNQ----MLLNLVPAHVAPGVIQKAG--DVWHHSHQSVGIAYIAVSGFDLEGEAGINGLN 741

  Fly   883 DIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQVLYRKES 947
            .:.:.||:.:..||.   |||:|.....|:.|.||....|::.                   .|:
 Worm   742 YVFSHFDQAIANYKG---VEKVKSANRFYIVAVGLLPDAAQNV-------------------NET 784

  Fly   948 KGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAGVVGASQP 1012
            ..|      :..:|:|.|   ..::|:...|..        :...:.||:..|..:|.|....||
 Worm   785 PWT------IGELMSTLA---HFIISISQFAME--------NEFHVQIGVDCGSTLAFVANTDQP 832

  Fly  1013 HYDIWGNPVNMA-SRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTF----VKGRGEIPTY-- 1070
            .|:|:|..::.: :.|::.|        .:|..:.|:..:....|.:.|    ||....:..|
 Worm   833 RYEIFGETLDRSRTLMQAAG--------HDTTLVSEEVFLALRPRPLRFSSQPVKVAMNLNAYEL 889

  Fly  1071 FVGIDDNLKFLPSNVKKN--------------NMSKRFSILSSLVPVHSRSTTSSE 1112
            ..|:.|....:|:..::.              |.|:.:...:|.:.....|:.|||
 Worm   890 VTGLRDVSVDIPTMPREEQERHTQGMVEAQFANQSRMYDTQTSEMASSMASSFSSE 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	89/375 (24%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	47/193 (24%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	43/226 (19%)
acy-3	NP_497765.4	AcyC	6..380	CDD:441717	91/383 (24%)
		Nucleotidyl_cyc_III	221..382	CDD:448371	44/184 (24%)
		CYCc	696..873	CDD:214485	42/225 (19%)