DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXB and gcy-29

DIOPT Version :9

Sequence 1:	NP_620474.2	Gene:	ACXB / 53427	FlyBaseID:	FBgn0040509	Length:	1114	Species:	Drosophila melanogaster
Sequence 2:	NP_001364597.1	Gene:	gcy-29 / 175116	WormBaseID:	WBGene00007314	Length:	1069	Species:	Caenorhabditis elegans

Alignment Length:	1212	Identity:	231/1212 - (19%)
Similarity:	420/1212 - (34%)	Gaps:	421/1212 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IRLMISYLTVFFPLFIFVVVGCELCPWIFSEQKKLIY-------YESLTAI------------VV 90
            :..|.||..:  |:|.:.....|     |:..|  :|       ::||.:|            :.
Worm   108 VATMASYWNI--PIFAYTATSAE-----FANTK--VYKTLLRTSFQSLNSISEATAAFMAHHNIT 163

  Fly    91 LVAVPGILSINFFESF-----VLRHRWIMV-----FSSILSA-------YIVVLVDIFQILVFHF 138
            ..|:...:..:.||..     .||.|.|.|     |....||       |:..|.|..::::..|
Worm   164 KAAIVANIGTDSFEKIQSLEKALRSRGITVARRVMFEEAASAQDLVDNGYMNELRDNARVILPIF 228

  Fly   139 KYHWPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVS--LMYIGLFIYFLKSDDEDI------- 194
            .....|:|::                 |.|..||...|  .:||...|....|::..:
Worm   229 SSTRDLSTVF-----------------RNATWLANMASPEFIYINPLIVARNSEEPPVFYGKMAQ 276

  Fly   195 -SEVVHDLDTICVDIFHYLGF--NLMGIFFRIMNDTMVRSSFLDRHQ--FLKEEMWLRQARQQES 254
             |....:.:||  .|::..||  :|:..|..|          .|::|  ::.|:.........||
Worm   277 KSIKAENPNTI--QIYNSYGFSDDLLNEFLAI----------FDQNQRIYIDEKDLFNYVALYES 329

  Fly   255 MLLDSILPPQIAKPIQQSIKE-------RI-----------MLSETDSDRIVVN--ARRTENFMA 299
            ..:.:    ::.:....|:||       ||           |..:...|.::.:  |.|..:|
Worm   330 FCVFA----KLTEKYLHSLKEKPEDGKIRIDGKALWNMAVGMTFQGVLDNVIFDNGAERMTSF-- 388

  Fly   300 IQIHPDVSILYAD-----VVNYTHLTTTLTVEKLVK------VLHDLYGRFDMAASTFKVQRIKF 353
                   |..|.|     :...:.:.:|:|.:..:.      |:.|:..:| .::.:.|:...:
Worm   389 -------SAFYVDEKRDQIRTVSLINSTVTSKNCMDPVCIELVVSDVVTKF-WSSPSGKLPDSE- 444

  Fly   354 LGDCYYCVAGLGEADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKL 418
             .:|     |..|.:.|:.:..| :..:::..|..|    .|.|.:|....:..|       .|:
Worm   445 -PEC-----GFREENCDYTQTIV-IATAVVCIILTV----FLGIWLRRACETSAL-------DKM 491

  Fly   419 QYDIWGPDVDIANRLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYLLT 483
            .:.::..||.|.:..:.           :::.|||.|      .|:::|.:..|.|.
Worm   492 PWRVFRDDVQILDEEQV-----------KSVVSLNSA------STKMSQVETKLIKN-------- 531

  Fly   484 AAPSRNSVRSVDAVHSYAEIDI----NALGASRKSPILRPTLMSDELREEFKKMPVGGFNIRSP- 543
                    .::..|:::|..|:    ..:..:|:..||. |.|...:.:.........||.:|.
Worm   532 --------HAIVGVNTHAVYDLYEQRQNIRFTREDLILL-TKMKQAVHDNINPFIGVSFNEKSEL 587

  Fly   544 ------CCRDNSNDEKVNHGLGMFCVAF-----------KDSSLEWSYLHKPDFILKYSVLLAWG 591
                  |.|....|.       ::|..|           :|.::...|||...  :.|.    .|
Worm   588 LLLWKFCSRGTLQDV-------IYCEKFAMDEKFQGAFVRDITMGLEYLHSSP--IGYH----GG 639

  Fly   592 IGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKK-----VC-----WWRCVENDSR 646
            :.|..:.|    ||                        :|..|     ||     |        .
Worm   640 LACWSVLI----DK------------------------NWMLKLTDYAVCDPLKRW--------E 668

  Fly   647 KYGRVSCKL----FKIWERIQHSFV---LRV-----------------TI---YMSIVASYYLLI 684
            |:||::||:    .|.|:::...:|   :|.                 ||   ..|.:.::.::|
Worm   669 KHGRINCKVDNEAEKQWQKMASLYVPPEIRTANEKNRLKRMDQKWQGQTILKRQQSDIYAFGVII 733

  Fly   685 STILLNCDKNQYELDVI--------NSKLYHYDIVTDNCFNPWVFTDMISLI-------VGVSYT 734
            ..||........::|:.        ..|:....|..:...||    |:|:|:       ..:..|
Worm   734 YEILFRSLPYDEKVDLTELAQKAAEGDKIQKPSIQRNKKLNP----DLIALLQDCWSDQPDMRPT 794

  Fly   735 FARIPFALKMLITCCATVAYLVIVFFQYSFIFEHSATTTPFMKAELAHCLRVCMMLLTMYAKERQ 799
            ..|:..|.::.:.                            .|..|...:   |.::..||...:
Worm   795 IRRVRLATEIALK----------------------------TKGNLVDSM---MRMMEEYANNLE 828

  Fly   800 SEFNTKINFKINQDLQGKQ-KAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMVSV 863
            .             |.|:: |.|:..|.....||..:||.||.   ::..|...:..:.|...:|
Worm   829 K-------------LVGERTKLAEEANLRAERLLFQLLPKHVA---IELKAGRTVAPKMYDSATV 877

  Fly   864 MFAMLINF------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLA 922
            ||:.::.|      ...:..:.:||.:.:|||.:::.:..|    |::.:|..||...|:..
Worm   878 MFSDIVGFTKLCSASTPIEVVNLLNKLYSEFDTVISKHDCY----KVETIGDAYMVVSGIPI--- 935

  Fly   923 KSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFI--MTTFALDLMRVLSVCNKAYAGRPFD 985
                                        ||....||.|  :|...:||::|..|.::.      |
Worm   936 ----------------------------ENGQRHVANISAVTLGIMDLLKVFEVPHRR------D 966

  Fly   986 RALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANIL---E 1047
            ..|:   |.:|.::|::.|.|||.|.|.|.::|..||:|:.|||:|..|.:.:| ||:.||   |
Worm   967 YRLT---IRLGFASGQVSAAVVGLSSPRYCLFGETVNIAAVMESSGEGGRVQIT-ETSKILLENE 1027

  Fly  1048 QFDIMCMYRGMTFVKGRGEIPTYFVGIDDNLKFLPSNVKKNN 1089
            ..:.:...||:.....:.:..||::...|...|    .||||
Worm  1028 YPEFIIEIRGINKDVKQDDFVTYWLTGKDEDYF----KKKNN 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	55/287 (19%)
		CYCc	249..459	CDD:214485	40/240 (17%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	32/196 (16%)
		CYCc	825..1047	CDD:214485	60/232 (26%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	57/229 (25%)
gcy-29	NP_001364597.1	PBP1_NPR_GC-like	27..403	CDD:380575	65/345 (19%)
		PKc_like	534..804	CDD:419665	57/323 (18%)
		CYCc	840..1033	CDD:214485	61/240 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900