Protein Alignment ACXB and gcy-12

DIOPT Version :9

• Sequence 1: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Sequence 2: NP_494995.2
• Gene: gcy-12 / 173902
• WormBaseID: WBGene00001538
• Length: 1679
• Species: Caenorhabditis elegans
• Alignment Length: 1292
• Identity: 236/1292 - (18%)
• Similarity: 411/1292 - (31%)
• Gaps: 474/1292 - (36%)

  Fly   104 ESFVLRHRWIM------VFSSILS-AYIVVLVDIFQ----ILVFHFKY----------------- 140
            |||..:...|:      .:.|::| |.:..:|:|.|    |..:..||
 Worm   119 ESFSKKLNQIVHCLTTDAYVSVVSGALVAAIVEINQDKDLIPAYQLKYVFGNTCGNDSHSTRLFM 183

  Fly   141 -HWPLNTLYDVFVLCMIYMFLPIPSIRGAALLATSVSLMYIGLFIYFLKSDDEDISEVVHDLDTI 204
             ||....  .||:       .|..:.:..|.:|.|.:|..|.     .:.:|:|||.
 Worm   184 EHWQAGA--RVFI-------GPEKNCKTEAAMAASQNLPIIS-----YRCNDQDISR-------- 226

  Fly   205 CVDIFHYLGF---------------NLMGIF----FRIMNDT---MVRSSFLD--------RHQF 239
              |.:||..|               :||..:    |.::.|.   .|::...:        .::|
 Worm   227 --DDYHYRTFARTVPPAGEIFKAFMSLMKQYNWRKFSVVYDVKKGQVKNELFETLKRMVETENKF 289

  Fly   240 LKEEMWLRQARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVV---NARRTENFMAIQ 301
            .:.:..:....:.|...:| |...|..:.|:.:||     |...:.||.:   |.|.....::|.
 Worm   290 EEHKFEIMNVSKLEFSKMD-ISSQQDIQSIENAIK-----STMQTTRIYLTFDNVRLFRTMLSIM 348

  Fly   302 -----IHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCV 361
                 ...|..::|.| .||..|          .|.|.:...|.....|:          .::..
 Worm   349 GEMGLTQQDYMLIYVD-TNYDWL----------NVYHSMNNHFLRNTMTY----------LHHSW 392

  Fly   362 AGLGEADP---DHARMAVSLGISMIANIQEVRAH----RALDIDMRIGVHSGTLLAG-------- 411
            .....:|.   |:||.|:|: |.....:...|.:    :|.|.....||.....|.|
 Worm   393 DANNSSDRKMLDYARSALSI-IPTPVKLNSQRFYNFWKKAGDYMHHFGVQKADNLKGNRIACYLY 456

  Fly   412 --------VIGQAKLQY---DIWGPDVD---IANRLEATGKPGYVHVSGRTLSSLNV-------- 454
                    .|.:...:|   |.:.|..|   |.:|:        |:...|::...::
 Worm   457 DAVYLYAKAIHELVEEYGNDDSYDPTADGKAIIDRI--------VNKKYRSIQGFDMRIDERGNS 513

  Fly   455 -AEYTVFPGTEVAQSDPILQKQPMTTYLLTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPILR 518
             ..:::....:||   ||:.|...:.|.|..|                 :|:.|:..........
 Worm   514 KGNFSLLSWQKVA---PIMNKSDPSYYPLDHA-----------------LDLTAIFVEAPDKDRL 558

  Fly   519 PTLMSDELREEFKK------MPVGGFNIRSPCCRDNSNDEKVNHGLGMFCVAFKDSSLEWSYLHK 577
            |.|.....|.::.|      .||.||:..:  ||..          |:|           |||..
 Worm   559 PNLQFKSSRIQWLKGEPPPDEPVCGFHGEN--CRKK----------GIF-----------SYLTV 600

  Fly   578 PDFIL--KYSVLLAWGIGCCLIYIQI------------------------VNDKFTICVECIVID 616
            ...||  .:|::|.   |..|.||:.                        ||::.|  ...:..|
 Worm   601 VVMILIAVFSLVLT---GFTLNYIRSRRFEKELSMIWKIDPYEVRRVVGGVNNEST--ASLMQSD 660

  Fly   617 MVVFTFLTSLLFISWFKKVCWW------------------RCVENDSRKYG-------RVSCKLF 656
            ::.|.          ..|..||                  ..|......||       |.:.|..
 Worm   661 VMQFA----------KTKTPWWSKAPVQGTGMRGLASYKGTLVGLKDLMYGRKPKDLTREAKKEL 715

  Fly   657 KIWERIQHSFVLRVTIYMSIVASYYLLISTILLNCDKN-------------------QYELDVIN 702
            :...::.|.   .|..::.|:...| .::.:...|.|.                   .:..|::.
 Worm   716 RAMRQLAHP---NVNNFLGIIVCQY-SVTVVREYCSKGSLHDILRNENLKLDHMYVASFVDDLVK 776

  Fly   703 SKLYHYD-----------------------------------IVTDNCFNPW---VFTDMISLIV 729
            ..:|.:|                                   |:.|:.:|.|   ::|...::.:
 Worm   777 GMVYIHDSELKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDSSYNIWENFLWTAPEAMTI 841

  Fly   730 GVS-------------YTFARI---------PFAL--------------KMLITCCATVAYLVIV 758
            ..|             |:|..|         |:.:              |..:.|.|.|...|..
 Worm   842 NGSLAISNPPTPKADAYSFGIIFHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVEKTVRR 906

  Fly   759 FFQ-------------YSFIFEHSATT---TPFMKAELAHCLRVCMMLLTMYAKER--------Q 799
            .:.             .:::.|..|..   .|:.:.|..........|.....|:.        .
 Worm   907 VYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEFKTIKNKLKPLFHQIYKQNIMDHMVLMM 971

  Fly   800 SEFNTKINFKINQ---DLQGKQKAADITNKSIIILLTNILPSHVVEVYLDSVANHELYYENYKMV 861
            .::.|::...:::   :|:.:|:.:.       .||..:|||.|.|..|   |..::..|.:..|
 Worm   972 EKYQTQLEDLVDERTIELKDEQRRSQ-------HLLQRMLPSSVAEQLL---AGQDVIPEAFPPV 1026

  Fly   862 SVMFAMLINF------QMDLPSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFT 920
            ::.|:.::.|      ...:..:..||.:.|.||.::..|..|    |::.:|..||...|:.
 Worm  1027 TIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVY----KVETIGDAYMVVSGVP-- 1085

  Fly   921 LAKSKFGSRTHASYSSELEQVLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFD 985
                                 .|:     |...|.|...:|....|..:|..|:.:
 Worm  1086 ---------------------QYK-----TMEYHAEQIAMMAIHILSAVRSFSIPH--------- 1115

  Fly   986 RALSTGEICIGISTGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFD 1050
            |:.....|.||:.||..:|||||.:.|.|.::|:.||.||||||.|....||.:..|..:|...|
 Worm  1116 RSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSID 1180

  Fly  1051 --IMCMYRGMTFVKGRGEIPTYFVG----------IDDNLKFLPSNVKKNNMSKRFS 1095
              .:...||...:||:|::.||::.          |:|.: .:|....:.|:..|.|
 Worm  1181 QGFLLEERGSLAIKGKGQMTTYWLNGRAGYEFTETIEDKM-VVPDIFPRPNLKNRGS 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXB	NP_620474.2	AC_N	<36..276	CDD:292831	44/230 (19%)
		CYCc	249..459	CDD:214485	46/255 (18%)
		Nucleotidyl_cyc_III	298..484	CDD:299850	41/228 (18%)
		CYCc	825..1047	CDD:214485	59/227 (26%)
		Nucleotidyl_cyc_III	853..1072	CDD:299850	59/226 (26%)
gcy-12	NP_494995.2	PBP1_Speract_GC_like	123..545	CDD:107365	88/501 (18%)
		ANF_receptor	140..519	CDD:279440	78/438 (18%)
		PK_GC-A_B	648..957	CDD:270944	42/324 (13%)
		TyrKc	688..951	CDD:197581	33/266 (12%)
		HNOBA	<967..1012	CDD:285003	10/51 (20%)
		CYCc	991..1183	CDD:214485	62/242 (26%)
		Guanylate_cyc	1018..1206	CDD:278633	59/228 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810